Navigation Links
Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
Date:7/10/2009

PITTSBURGH, July 10 The secret to longevity may lie in an enzyme with the ability to promote a robust immune system into old age by maintaining the function of the thymus throughout life, according to researchers studying an "anti-aging" mouse model that lives longer than a typical mouse.

The study, led by Abbe de Vallejo, Ph.D., associate professor of pediatrics and immunology, University of Pittsburgh School of Medicine, and immunologist at Children's Hospital of Pittsburgh of UPMC, reports that the novel mouse model has a thymus that remains intact throughout its life. In all mammals, the thymus―the organ that produces T cells to fight disease and infection―degenerates with age.

Results of the study are published in this week's issue of the Proceedings of the National Academy of Sciences.

"These findings give us hope that we may one day have the ability to restore the function of the thymus in old age, or perhaps by intervening at an early age, we may be able to delay or even prevent the degeneration of the thymus in order to maintain our immune defenses throughout life," said Dr. de Vallejo.

The mouse model that Dr. de Vallejo's team studied was developed by his colleague Cheryl Conover, Ph.D., an endocrinology researcher at Mayo Clinic. In this "knockout" mouse model, researchers deleted an enzyme known as pregnancy-associated plasma protein A (PAPPA). PAPPA-knockout mice live at least 30 percent longer and have significantly lower occurrence of spontaneous tumors than typical mice.

PAPPA controls the availability in tissues of a hormone known as insulin-like growth factor (IGF) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth. But IGF also is associated with tumor growth, inflammation and cardiovascular disease in adults. By deleting PAPPA, the researchers were able to control the availability of IGF in tissues and dampen its many ill e
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childrens Hospital Oakland scientists first to discover new source for harvesting stem cells
2. Childrens Hospital Oakland is first pediatric hospital to use laboratory-on-a-card technology
3. Research could lead to new non-antibiotic drugs to counter hospital infections
4. Mount Sinai Hospital researcher makes stem cell breakthrough
5. International copper industry defines role in the fight against hospital infections
6. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. First results from hospital trials testing
9. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
10. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
11. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Chicago is creating a new professorship in tissue ... Institute for Molecular Engineering and the Marine Biological ... the Millicent and Eugene Bell Foundation., The Eugene ... the Institute for Molecular Engineering. That endowed chair ... the MBL,s Eugene Bell Center for Regenerative Biology ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... researchers from The Chinese University of Hong Kong, BGI ... soybean linked to salt tolerance, with implication for improving ... study published online in Nature Communications provides ... crop improvement. , Soybean is an important crop for ... soybeans have less genetic diversities than their wild counterparts. ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2BGI reports a novel gene for salt tolerance found in wild soybean 2
... This release is available in German . ... hibernating common pipistrelle bats under harsh conditions of snow cover. ... Max Planck Institute for Ornithology in Seewiesen and their colleagues ... birds alternative feed, they ate it and showed little or ...
... parasites from spreading throughout the body has seen Dr ... named a Young Tall Poppy by the Australian Institute ... postdoctoral fellow in the institute,s Infection and Immunity division, ... parasite,s movement. "Malaria parasites use a unique ...
... Park of Cornell University, who receives funding for basic ... (AFOSR), is investigating carbon nanostructures that may some day ... for the Air Force. "Devices that are required ... different from commercial ones in the sense that they ...
Cached Biology News:Great tits eat bats in times of need 2Malaria research wins Jake Baum a Young Tall Poppy award 2AFOSR's basic research may lead to revolutionary new devices 2
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and ... on a single charge with the help of a ... material to replace the graphite traditionally used in one ... 10 times the energy storage capacity of graphite. A ... electrode was published today in Nature Communications . ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:7/10/2014)... two universities and NPL collaborate to bring together their ... their complementary academic strengths., Working with BIS and NPL ... priorities of the UK. The establishment of a Graduate ... students, will provide a pipeline of skilled researchers. Working ... Laboratory will be grown through the creation of a ...
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
Breaking Biology Technology:Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3A deeper look at interfaces 2
... Nanometre-scale gold particles are currently intensively investigated for ... carriers and molecular electronics. The particles are prepared ... reactive gold cores can be stabilised with various ... by using organothiolate ligands that have a strong ...
... Cord Blood Corporation (NYSE: CO ) ("CCBC" or ... testing, hematopoietic stem cell processing, and stem cell storage services, ... first nine months of fiscal year 2011 ended December 31, ... of Fiscal 2011 Highlights Revenue ...
... 2011 Epeius Biotechnologies ( www.epeiusbiotech.com ) announced today that ... Company,s lead anti-cancer agent, Rexin-G , the first, and ... to seek out and destroy metastatic cancer. According to Dr. ... in terms of clinical development, is that the Rexin-G product, ...
Cached Biology Technology:Fingerprints of a gold cluster revealed 2China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 2China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 3China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 4China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 5China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 6China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 7China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 8China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 9China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 10China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 11Epeius Biotechnologies' REXIN-G, a Tumor-Targeted Genetic Medicine for Metastatic Cancer, Gains Phase 3 Product Designation From the U.S. FDA 2
... Science, which pioneered the blending of thermostable ... and Expand Long Template PCR Systems, now ... the first product of a family ... blend combines Taq DNA Polymerase with a ...
... Polyribonucleotides (RNA polymers) are ... action of the enzyme, ... Midland, and the appropriate, ... With the exception of ...
... shaker flask clips, purpose-designed to firmly retain ... clips are equipped with a top retainer ... a bottom retainer spring, and silicon tubing ... glassware. Clips include the required mounting ...
RABBIT ANTI HUMAN ALPHA-2-ANTIPLASMIN...
Biology Products: