Navigation Links
Childrens Hospital LA discovers growth factor essential to epicardial cell function
Date:10/5/2010

LOS ANGELES In research that one day may lead to the discovery of how to regenerate tissue damaged by heart disease, investigators at Childrens Hospital Los Angeles have identified PDGF as a key factor in the proliferation and transformation of epicardial cells, one type of cell that surrounds heart muscle and contributes to vessels.

The study was published online September 21 in advance of the publication of the Proceedings of the National Academy of Sciences of the United States of America. Ching-Ling (Ellen) Lien, PhD, led a team of researchers at the Developmental Biology and Regenerative Medicine Program and Heart Institute that included Jieun Kim, PhD, Qiong Wu, MS, Yolanda Zhang, MD, Katie M. Wiens, PhD, Ying Huang, MS, Nicole Rubin, BS. The research was supported by Vaughn A. Starnes, MD director of the Childrens Hospital Los Angeles Heart Institute, and joined by Hiroyuki Shimada, MD, Tai-lan Tuan, PhD, of The Saban Research Institute of Childrens Hospital.

The team demonstrated that PDGF 'signaling' is required for epicardial cell proliferation, as well as supportive cell and coronary blood vessel formation leading to regeneration of cardiac tissue in zebrafish.

Although adult human hearts cannot generate new cardiac muscle, the tiny, freshwater zebrafish is capable of fully regenerating its heart after injury or amputation. Because of this unique ability to regenerate, the zebrafish has become a model for studying ways of possibly 'turning on' the repair process in the human heart.

In zebrafish, newly formed coronary vessels supply blood to the regenerating heart. The development of coronary blood vessels during zebrafish heart regeneration has been postulated to occur in the same way as the heart and vessels were originally formed in the embryo. Dr. Lien, an assistant professor of surgery at the Keck School of Medicine at the University of Southern California, and her team found biochemical marker
'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Page: 1 2

Related biology news :

1. McLean Hospital researchers awarded $1.9 9 million grant for stem cell, blood research
2. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
3. Opioid use to relieve pain and suffering at end of life is safe in hospital-at-home setting
4. Researchers at Childrens Hospital Los Angeles find diet-induced obesity accelerates leukemia
5. Memorial Hospital Selects DigitalPersona Pro to Enhance HIPAA Security
6. Texas Childrens Hospital vaccine experts present 4 studies
7. Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms
8. Temple University Hospital and PASNAP Negotiations Break Off: Talks to Resume Later Today
9. Researchers find Clostridium difficile is more common than MRSA in southeast community hospitals
10. Hospital scanner could curb nuclear waste threat
11. University Hospitals Case Medical Center testing gene therapy for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childrens Hospital LA discovers growth factor essential to epicardial cell function
(Date:7/11/2014)... many fires burning in eastern New South Wales, Australia ... , At 03:35 UTC on July 11 (12:35 p.m. ... passed over eastern New South Wales (NSW), the Moderate ... image of the region and spotted smoke (light brown) ... thermal bands, are outlined in red. , The New ...
(Date:7/11/2014)... set a "mouse TRAP" to capture the early signs ... published in the Journal of Clinical Investigation . ... TRAP to extract cellular and genetic information from a ... the Rockefeller Institute for Medical Research in 2008, TRAP ... or ribosomes, of the cell type of interest. Scientists ...
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... The standard explanation for what causes Alzheimer,s is known ... from of an accumulation of the peptide amyloid beta, the ... the sticky plaques that have defined Alzheimer,s for more than ... spent yearly targeting this toxic peptide but what if ...
... host a conference celebrating the 200th anniversary of ... of Species and the 50th anniversary of the ... Thursday, Oct. 29 to Saturday, Oct. 31. ... History of Science, Darwin/Chicago 2009 will feature presentations ...
... Birmingham (UAB) researchers exploring strategies for conserving the Diamondback ... keep the once-celebrated turtle off the endangered species list. ... a source of state taxes and a casualty of ... its prospects are improved by a UAB-based turtle hatchery ...
Cached Biology News:Rethinking Alzheimer's disease and its treatment targets 2Rethinking Alzheimer's disease and its treatment targets 3UAB research team saves turtle species on the brink 2UAB research team saves turtle species on the brink 3
(Date:7/10/2014)... of psychiatric disorders has been extremely challenging because there ... are insufficient to cause disease. Now investigators reporting in ... Cell Stem Cell describe a strategy that ... with other risk factors or environmental exposures to affect ... a genetic variant that may predispose individuals to schizophrenia. ...
(Date:7/10/2014)... that power our laptops and electric vehicles could store ... with the help of a sponge-like silicon material. ... graphite traditionally used in one of the battery,s electrodes, ... storage capacity of graphite. A paper describing the material,s ... in Nature Communications . , "Silicon has long ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:7/10/2014)... will see the two universities and NPL collaborate to ... and industry and their complementary academic strengths., Working with ... shape the scientific priorities of the UK. The establishment ... 300 high-calibre PhD students, will provide a pipeline of ... potential of the Laboratory will be grown through the ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... The CHEMICON® CaspaTag™ Pan-Caspase In Situ ... detection of active caspases in cells undergoing ... only. Not for use in diagnostic or ... Assay Kits use a novel approach to ...
... nM is available for in vivo ... in: Z. Hassani, G.-F. Lemkine, P. Erbacher, ... B.-A. Demeneix. Lipid-mediated siRNA delivery down regulates ... at picomolar levels. J. Gene Med., 2005, ...
... transfection reagent that achieves over 90 % ... a wide variety of adherent and primary ... siRNA concentrations avoids unwanted toxic and off-target ... higher concentrations, thereby allowing accurate and reliable ...
... Immunoperoxidase Secondary Detection System uses biotin-avidin-HRP complexed ... in the Primary Antibody. The primary antibody ... specimen. Any excess antibody is removed by ... to biotin) is added and will react ...
Biology Products: