Navigation Links
Childrens Hospital LA discovers growth factor essential to epicardial cell function
Date:10/5/2010

LOS ANGELES In research that one day may lead to the discovery of how to regenerate tissue damaged by heart disease, investigators at Childrens Hospital Los Angeles have identified PDGF as a key factor in the proliferation and transformation of epicardial cells, one type of cell that surrounds heart muscle and contributes to vessels.

The study was published online September 21 in advance of the publication of the Proceedings of the National Academy of Sciences of the United States of America. Ching-Ling (Ellen) Lien, PhD, led a team of researchers at the Developmental Biology and Regenerative Medicine Program and Heart Institute that included Jieun Kim, PhD, Qiong Wu, MS, Yolanda Zhang, MD, Katie M. Wiens, PhD, Ying Huang, MS, Nicole Rubin, BS. The research was supported by Vaughn A. Starnes, MD director of the Childrens Hospital Los Angeles Heart Institute, and joined by Hiroyuki Shimada, MD, Tai-lan Tuan, PhD, of The Saban Research Institute of Childrens Hospital.

The team demonstrated that PDGF 'signaling' is required for epicardial cell proliferation, as well as supportive cell and coronary blood vessel formation leading to regeneration of cardiac tissue in zebrafish.

Although adult human hearts cannot generate new cardiac muscle, the tiny, freshwater zebrafish is capable of fully regenerating its heart after injury or amputation. Because of this unique ability to regenerate, the zebrafish has become a model for studying ways of possibly 'turning on' the repair process in the human heart.

In zebrafish, newly formed coronary vessels supply blood to the regenerating heart. The development of coronary blood vessels during zebrafish heart regeneration has been postulated to occur in the same way as the heart and vessels were originally formed in the embryo. Dr. Lien, an assistant professor of surgery at the Keck School of Medicine at the University of Southern California, and her team found biochemical markers consistent with embryonic development in the regenerated zebrafish hearts.

The team also found that when PDGF signaling was blocked, epicardial cell proliferation, expression of the embryonic biochemical markers, and coronary blood vessel development were impaired.

"By understanding the mechanism involved in developing a new blood supply to injured cardiac tissue, we can begin to develop a therapeutic strategy for the treatment of heart disease in humans," noted Dr. David Warburton, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute.


'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Related biology news :

1. McLean Hospital researchers awarded $1.9 9 million grant for stem cell, blood research
2. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
3. Opioid use to relieve pain and suffering at end of life is safe in hospital-at-home setting
4. Researchers at Childrens Hospital Los Angeles find diet-induced obesity accelerates leukemia
5. Memorial Hospital Selects DigitalPersona Pro to Enhance HIPAA Security
6. Texas Childrens Hospital vaccine experts present 4 studies
7. Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms
8. Temple University Hospital and PASNAP Negotiations Break Off: Talks to Resume Later Today
9. Researchers find Clostridium difficile is more common than MRSA in southeast community hospitals
10. Hospital scanner could curb nuclear waste threat
11. University Hospitals Case Medical Center testing gene therapy for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childrens Hospital LA discovers growth factor essential to epicardial cell function
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced the ... NIH to develop RealSeq®-SC (Single Cell), expected to be ... small RNAs (including microRNAs) from single cells using NGS ... the need to accelerate development of approaches to analyze ... "New techniques for measuring levels of mRNAs ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions to ... symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory science, ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
Breaking Biology Technology: