Navigation Links
Childrens Hospital LA discovers growth factor essential to epicardial cell function
Date:10/5/2010

LOS ANGELES In research that one day may lead to the discovery of how to regenerate tissue damaged by heart disease, investigators at Childrens Hospital Los Angeles have identified PDGF as a key factor in the proliferation and transformation of epicardial cells, one type of cell that surrounds heart muscle and contributes to vessels.

The study was published online September 21 in advance of the publication of the Proceedings of the National Academy of Sciences of the United States of America. Ching-Ling (Ellen) Lien, PhD, led a team of researchers at the Developmental Biology and Regenerative Medicine Program and Heart Institute that included Jieun Kim, PhD, Qiong Wu, MS, Yolanda Zhang, MD, Katie M. Wiens, PhD, Ying Huang, MS, Nicole Rubin, BS. The research was supported by Vaughn A. Starnes, MD director of the Childrens Hospital Los Angeles Heart Institute, and joined by Hiroyuki Shimada, MD, Tai-lan Tuan, PhD, of The Saban Research Institute of Childrens Hospital.

The team demonstrated that PDGF 'signaling' is required for epicardial cell proliferation, as well as supportive cell and coronary blood vessel formation leading to regeneration of cardiac tissue in zebrafish.

Although adult human hearts cannot generate new cardiac muscle, the tiny, freshwater zebrafish is capable of fully regenerating its heart after injury or amputation. Because of this unique ability to regenerate, the zebrafish has become a model for studying ways of possibly 'turning on' the repair process in the human heart.

In zebrafish, newly formed coronary vessels supply blood to the regenerating heart. The development of coronary blood vessels during zebrafish heart regeneration has been postulated to occur in the same way as the heart and vessels were originally formed in the embryo. Dr. Lien, an assistant professor of surgery at the Keck School of Medicine at the University of Southern California, and her team found biochemical markers consistent with embryonic development in the regenerated zebrafish hearts.

The team also found that when PDGF signaling was blocked, epicardial cell proliferation, expression of the embryonic biochemical markers, and coronary blood vessel development were impaired.

"By understanding the mechanism involved in developing a new blood supply to injured cardiac tissue, we can begin to develop a therapeutic strategy for the treatment of heart disease in humans," noted Dr. David Warburton, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute.


'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Related biology news :

1. McLean Hospital researchers awarded $1.9 9 million grant for stem cell, blood research
2. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
3. Opioid use to relieve pain and suffering at end of life is safe in hospital-at-home setting
4. Researchers at Childrens Hospital Los Angeles find diet-induced obesity accelerates leukemia
5. Memorial Hospital Selects DigitalPersona Pro to Enhance HIPAA Security
6. Texas Childrens Hospital vaccine experts present 4 studies
7. Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms
8. Temple University Hospital and PASNAP Negotiations Break Off: Talks to Resume Later Today
9. Researchers find Clostridium difficile is more common than MRSA in southeast community hospitals
10. Hospital scanner could curb nuclear waste threat
11. University Hospitals Case Medical Center testing gene therapy for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childrens Hospital LA discovers growth factor essential to epicardial cell function
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ... Market in Retail Sector 2016-2020" report ... Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has ...
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... significant achievements are the result of the company,s laser ... iMedNet eClinical , it,s comprehensive, easy-to-use and highly ... --> Key MedNet growth achievements in 2015 ...
(Date:1/15/2016)... SAN JUAN, Puerto Rico , Jan. 15, 2016 ... forcing companies big and small to find new ways ... data driven culture. iOS and ... their device based on biometrics, transforming it into a ... can request that users swipe their fingerprint on their ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Dovetail Genomics™ LLC ... its beta program for a planned metagenomic genome assembly ... the company,s metagenomic genome assembly method in a talk ... Genome Biology & Technology conference in Orlando, ... these highly complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global ... treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols and ... from around the world. , The new GSCG clinic is headed by ...
(Date:2/10/2016)... is introducing a hybrid membership model which will provide ... joining or renewing through an organizational purchasing model. For ... employee in any size association or AMC office can ... benefits.   John H. Graham, IV , ... organizations of any size and their employees to gain ...
(Date:2/10/2016)... Texas (PRWEB) , ... February 10, 2016 , ... ... centers across three states, announced today the promotion of two long-standing principal investigators ... Chief of Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a ...
Breaking Biology Technology: