Navigation Links
Children with autism more likely to have mitochondrial defects impacting cellular energy production
Date:11/30/2010

NEW YORK, N.Y. (December 1, 2010) A new study published in the Journal of the American Medical Association (JAMA) and partially funded by Autism Speaks, found that children with autism have more trouble fueling the energy demands of their cells due to dysfunctional mitochondria. These new findings from UC Davis reveal several different types of mitochondrial dysfunction and suggest a novel way of screening for these deficits using blood samples.

Mitochondria, the "powerhouses" of cells, provide energy for cell functions through a cascade of enzyme complexes. Together, those enzyme complexes create energy through a process called oxidative phosphorylation. Previous studies have shown that mitochondrial dysfunction can lead to a host of disorders particularly affecting brain cells which are characterized by high energy demands. Although mitochondrial dysfunction has previously been suspected in some individuals with autism spectrum disorders, the evaluation was difficult, and typically required a sample from muscle cells.

For the study, blood samples were taken from ten children with autism and ten unrelated typically developing children, all aged 2-5 years. The researchers analyzed mitochondria in children's white blood cells. Mitochondria in the samples from children with autism were less efficient at creating energy through oxidative phosphorylation. In some, there was a genetic mutation that affected mitochondrial function. In others, the researchers observed that one or more enzyme complexes were dysfunctional. In most of the children with autism, there were many extra copies of mitochondria, which may partially compensate for each one not working optimally.

"It is remarkable that evidence of mitochondrial dysfunction and changes in mitochondrial DNA were detected in the blood of these young children with autism," said Geraldine Dawson, Ph.D., Autism Speaks chief science officer. "We look forward to seeing other groups replicate these findings. We need to understand why these differences exist. One of the challenges has been that it has been difficult to diagnose mitochondrial dysfunction because it usually requires a muscle biopsy. If we could screen for these metabolic problems with a blood test it would be a big step forward."

Cecilia Giulivi, the study's lead author, is a biochemist in the Department of Molecular Biosciences in the School of Veterinary Medicine at UC Davis and is a recipient of an Autism Speaks Pilot Award. Isaac Pessah, director of the Center for Children's Environmental Health and Disease Prevention at UC Davis MIND Institute, a recipient of an Autism Speaks Environmental Innovator Award, is a co-author. Other study authors include Yi-Fan Zhang, Alicja Omanska-Klusek, Catherine Ross-Inta, Sarah Wong, Irva Hertz-Picciotto and Flora Tassone of UC Davis.

"The real challenge now is to try and understand the role of mitochondrial dysfunction in children with autism," said Pessah. "For instance, many environmental stressors can cause mitochondrial damage. Depending on when a child was exposed, maternally or neonatally, and how severe that exposure was, it might explain the range of the symptoms of autism."


'/>"/>

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
Autism Speaks
Source:Eurekalert  

Related biology news :

1. Gene links to anorexia found by Childrens Hospital of Philadelphia researchers
2. Childrens Hospital of Philadelphia collaborates in gene therapy success in an immune disorder
3. Study shows young, unsupervised children most at risk for dog bites
4. Fearless children show less empathy, more aggression
5. Overweight children have different eating patterns than normal weight children
6. Comprehensive nutrition services vital to childrens health
7. OHSU Doernbecher Childrens Hospital conducts second phase of landmark Batten study
8. Center to study effects of plastics chemicals on childrens health
9. Childrens agitation after surgery may be preventable
10. NIH funds Center of Excellence for Molecular Hematology at Cincinnati Childrens
11. Childrens Hospital LA discovers growth factor essential to epicardial cell function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children with autism more likely to have mitochondrial defects impacting cellular energy production
(Date:2/28/2017)... Spanien, 27. Februar 2017  EyeLock LLC, ein marktführendes ... seine erstklassige biometrische Lösung zur Iris-Erkennung auf ... X16 LTE auf dem Mobile World Congress ... Qualcomm-Stand in Halle 3, Stand 3E10, vorstellen. ... Sicherheitsplattform Qualcomm Haven™ – eine Kombination aus ...
(Date:2/21/2017)... PORTLAND, Ore. , Feb. 22, 2017 /PRNewswire/ ... of Companies (Avamere Health Services, Infinity Rehab, Signature Hospice, ... study that will apply the power of IBM cognitive ... and health centers. By analyzing data streaming from sensors ... into physical and environmental conditions, and obtain deeper learnings ...
(Date:2/13/2017)... 2017 Former 9/11 Commission border counsel and ... Janice Kephart of Identity Strategy Partners, LLP, today ... "Executive Order: Protecting the Nation From Foreign Terrorist ... "As President Trump,s ,Travel Ban, Executive Order gains ... banned the travel ban, it is important that our ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... , March 24, 2017 Agenus Inc. ... immune checkpoint antibodies and cancer vaccines, today announced participation ... 7 th  Annual William Blair and Maidstone Life Sciences ... Alexandria Center in New York, NY ... March 29 at 9:40 am: Robert B. ...
(Date:3/23/2017)... 23, 2017  SeraCare Life Sciences, Inc., a ... vitro diagnostics manufacturers and clinical laboratories, is ... multiplexed Inherited Cancer reference material ... next-generation sequencing (NGS). The Seraseq™ Inherited Cancer DNA ... from industry experts to validate the ability ...
(Date:3/23/2017)... NetworkNewsWire Editorial Coverage  ... Cancer remains one of the world,s ... systems, in terms of costs and resources. However, as the ... of innovative and efficient therapies that demonstrate higher chances of ... cancer treatments, a growing number of patients receiving immuno-oncology therapies ...
(Date:3/22/2017)... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a major research ... GSK to generate genetic sequence data from the 500,000 volunteer ... researchers to gain valuable insights to support advances in the ... and life threatening diseases. ... Genetic evidence has revolutionized scientific discovery ...
Breaking Biology Technology: