Navigation Links
Children with autism more likely to have mitochondrial defects impacting cellular energy production
Date:11/30/2010

NEW YORK, N.Y. (December 1, 2010) A new study published in the Journal of the American Medical Association (JAMA) and partially funded by Autism Speaks, found that children with autism have more trouble fueling the energy demands of their cells due to dysfunctional mitochondria. These new findings from UC Davis reveal several different types of mitochondrial dysfunction and suggest a novel way of screening for these deficits using blood samples.

Mitochondria, the "powerhouses" of cells, provide energy for cell functions through a cascade of enzyme complexes. Together, those enzyme complexes create energy through a process called oxidative phosphorylation. Previous studies have shown that mitochondrial dysfunction can lead to a host of disorders particularly affecting brain cells which are characterized by high energy demands. Although mitochondrial dysfunction has previously been suspected in some individuals with autism spectrum disorders, the evaluation was difficult, and typically required a sample from muscle cells.

For the study, blood samples were taken from ten children with autism and ten unrelated typically developing children, all aged 2-5 years. The researchers analyzed mitochondria in children's white blood cells. Mitochondria in the samples from children with autism were less efficient at creating energy through oxidative phosphorylation. In some, there was a genetic mutation that affected mitochondrial function. In others, the researchers observed that one or more enzyme complexes were dysfunctional. In most of the children with autism, there were many extra copies of mitochondria, which may partially compensate for each one not working optimally.

"It is remarkable that evidence of mitochondrial dysfunction and changes in mitochondrial DNA were detected in the blood of these young children with autism," said Geraldine Dawson, Ph.D., Autism Speaks chief science officer. "We look forward to seeing oth
'/>"/>

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
Autism Speaks
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene links to anorexia found by Childrens Hospital of Philadelphia researchers
2. Childrens Hospital of Philadelphia collaborates in gene therapy success in an immune disorder
3. Study shows young, unsupervised children most at risk for dog bites
4. Fearless children show less empathy, more aggression
5. Overweight children have different eating patterns than normal weight children
6. Comprehensive nutrition services vital to childrens health
7. OHSU Doernbecher Childrens Hospital conducts second phase of landmark Batten study
8. Center to study effects of plastics chemicals on childrens health
9. Childrens agitation after surgery may be preventable
10. NIH funds Center of Excellence for Molecular Hematology at Cincinnati Childrens
11. Childrens Hospital LA discovers growth factor essential to epicardial cell function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children with autism more likely to have mitochondrial defects impacting cellular energy production
(Date:8/19/2014)... team of UTSA researchers has been awarded a nearly ... and Training (NCPTT), an office of the National Park ... grant will fund a one-year study of the energy ... historic homes in hot, humid climates. , Radiant barriers ... attics that reflect heat back, thereby reducing the amount ...
(Date:8/19/2014)... Plants are superior to humans and animals in a ... regenerate, which enables them to regrow entire organs. After ... grow back its entire crown. But there is one ... quite literally rooted to the habitats in which they ... elements. In response to this dilemma, plants have developed ...
(Date:8/19/2014)... This news release is available in French . ... Stand: balancing the BENEFITS and RISKS of physical activity ... a stand on the promotion of childhood physical activity ... Applied Physiology, Nutrition, and Metabolism ( APNM ... of knowledge in the area of risk of physical ...
Breaking Biology News(10 mins):UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3How steroid hormones enable plants to grow 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3
... model for human exercise? According an article published in the ... habits make it a prime model of cardiovascular fitness. The ... requirements, and, according to the authors, this cold-blooded snake may ... adapting to prolonged exercise and in response to some diseases. ...
... isolated the first human embryonic stem cell lines specifically tailored ... females of various ages, suffering from disease or spinal cord ... Science, which is published by AAAS, the non-profit science society, ... These cell lines will enable the study of human disease ...
... issue of Science holds mixed blessings for scientists who ... The study, conducted by scientists from Cincinnati Children's Hospital ... in Germany, reveals important evidence that tells us more ... other hand, scientists offer caution in regards to the ...
Cached Biology News:Scientists generate patient-specific stem cells, Science study says 2Scientists generate patient-specific stem cells, Science study says 3Scientists generate patient-specific stem cells, Science study says 4Science study holds implications for gene therapy and stem cell biology 2Science study holds implications for gene therapy and stem cell biology 3
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced two ... adding to the company’s extensive line-up of HPLC ... operating environment, and full automation, the i-Series provides ... conventional to ultra-high-speed analysis. , The ... so users can begin building the lab of ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 ... to raise $200,000 to fund a corporate lab ... , This development is a critical component ... of care to the implementation of personalized medicine ... of practicing medicine. , Indiegogo contributions will support ...
(Date:8/19/2014)... August 19, 2014 XenoTech announces ... and cost-effective metabolite production from bioactive small molecules. ... platform, the technology enables convenient and timely assessment ... to XenoTech’s Vice President of Commercial Operations, Christian ... assessing clinical risk can be measured directly by ...
(Date:8/19/2014)... 2012, the European Union (EU) mandated use of the ICH-recommended ... – responding to the increasing need to understand and manage ... many regions, the main objectives of the PBRER are to:, ... of new or emerging information on the risks of a ... potential benefits of a drug; and , Allow ...
Breaking Biology Technology:Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2
... ST. LOUIS, Aug. 18 Sigma-Aldrich® Corporation (Nasdaq: ... Borg has been named Vice President and Chief Information ... Borg will lead the Company,s global information systems function ... Chief Financial Officer and Chief Administrative Officer. ...
... Bulletin Board: WDSTD ), a development stage ... initial $3.25 million funding in conjunction with its acquisition ... by Lonza Walkersville ("Lonza Agreement").  Lonza Walkersville is a ... the world,s leading suppliers to the pharmaceutical, healthcare and ...
... in... -- JERUSALEM and NEEDHAM, Massachusetts, August 18, 2010, ... ... ... Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Biology Technology:Sigma-Aldrich Announces Appointment of Magnus Borg as Vice President and Chief Information Officer (CIO) 2Regenicin Completes Acquisition of Worldwide Exclusive Know-How Technology License from Lonza Walkersville 2Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 2Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 3Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 4Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 5Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 6Oridion Signs New Distributor Agreement With IMI Expanding its Presence in the Japanese Market 7
...
...
Anti 4-hydroxy-2-hexenal (4-HHE) Monoclonal Antibody (HNEJ-2)...
... in immunostaining ,This solution has effect on ... get clearer signal than the one obtained ... amount of secondary antibody used and exposure ... can have images with high S/N ratio ...
Biology Products: