Navigation Links
Children born from frozen embryos weigh more and do better than those born after fresh transfer
Date:7/8/2008

This release is available in Spanish.

Barcelona, Spain: Children born after a frozen, thawed embryo has been replaced in the womb have higher birth weight than those born where fresh embryos were used, Danish scientists reported to the 24th annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 8 July). The mothers had longer pregnancies, and the children did not show an increased risk of congenital malformations, said Dr. Anja Pinborg, from the Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

The scientists studied all the 1267 children born in Denmark between 1995 and 2006 after frozen embryo replacement (FER). The children were divided into three groups; those born after cryo-preserved IVF (878), those born after cryo-preserved ICSI (310), and 79 where the method of creation of the embryos was unknown. During the same period 17857 children were born after IVF/ICSI treatment using fresh embryos, and these children were used as controls. Data on the children's outcomes, including congenital malformations, were obtained from Danish national registries.

Freezing embryos allows couples to have several cycles of IVF/ICSI from the same egg collection. The embryos are subsequently thawed and replaced three to five days after ovulation in exactly the same way as fresh embryos are used. The technique helps to reduce the number of times ovaries are stimulated and eggs collected.

The scientists found similar rates of multiple pregnancies in the FER groups (ICSI 11.7% and IVF 14.2%), but in the fresh embryo groups the rates were considerably higher (ICSI 24.8% and IVF 27.3%). Maternal age was significantly higher in the FER group. Pregnancy duration was significantly longer for these mothers, and birth weight was also higher about 200 grams in the FER group. The proportion of low birth weight FER children significantly lower, as was the percentage of pre-term births.

"Additionally there were significantly fewer children admitted to a neonatal intensive care unit in the FER group," said Dr. Pinborg, "although, when limited to single births, this difference disappeared. Most encouragingly, we found no increased risk of congenital malformations in the FER group; the rate in this group was 7.1% compared to 8.8% where fresh embryos had been used."

Concerns had previously been raised about the effect of freezing and thawing of embryos, but this study has laid them to rest, the scientists say. "Up till now the data has been extremely limited," said Dr. Pinborg. "There is only one other large birth register study from Sweden which shows similar results to ours. Our findings are of particular importance for Scandinavian countries, where single elective embryo transfer is regarded as the gold standard. This has meant that the use of FER has been rising steadily over the past few years. We wanted to be sure that the procedure had no deleterious effect on the offspring," said Dr. Pinborg.

"The findings are reassuring, although we still lack sub-analyses regarding malformations and neurological sequelae of the FER. But if our results continue to be positive, FER can be accepted as a completely safe procedure, which can be used even more frequently than it is currently," she said.


'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
34-932-308-810
European Society for Human Reproduction and Embryology
Source:Eurekalert

Related biology news :

1. Children born after donor insemination should be told as soon as possible about their conception
2. New research: Fruit juice consumption not related to overweight in children
3. Childrens gardens mushrooming
4. Gene therapy slows progression of fatal neurodegenerative disease in children
5. May 14 AAAS Lecture and videoteleconference on artworks by Siberian schoolchildren
6. Domestic violence associated with chronic malnutrition in women and children in India
7. Possible link between baby swimming and breathing problems in children
8. Childrens Hospital leads projects to develop nations first heart assist devices for young children
9. Leading pediatrician addresses the future of childrens health
10. Tooth Bank seeks milk teeth from 100,000 children
11. The evolution of aversion: Why even children are fearful of snakes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... CA (PRWEB) , ... October 11, 2017 , ... ... upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding the ... system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
(Date:10/11/2017)... , ... October 11, 2017 , ... Disappearing forests and ... lives of over 5.5 million people each year. Especially those living in larger cities ... Treepex - based in one of the most pollution-affected countries globally - decided to ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
Breaking Biology Technology: