Navigation Links
Childhood virus infection linked to prolonged seizures with fever
Date:6/13/2012

New research shows that human herpesviruses (HHV)-6B and HHV-7, commonly know as roseola virus), account for one third of febrile status epilepticus (FSE) cases. Results of the FEBSTAT prospective study now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE), suggest that HHV-6B may be involved in the development of epilepsy and further research is urgently needed.

FEBSTAT is a multi-center study of the consequences of FSE, designed to identify the factors that increase the risk of injury to the hippocampus, an area of the brain responsible for long-term memory and implicated in the development of temporal lobe epilepsy. The FEBSTAT study is funded by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH).

According to previous research, up to 5% of children under the age of five have febrile seizures, making it the most common type of seizure, with peak incidence at age 2. While brief or simple febrile seizures are most common, 5% - 8% of cases are prolonged and meet the criteria for status epilepticus (SE)a critical condition where a persistent seizure lasts more than 30 minutes. Experts suggest that FSE accounts for 5% of FS; however, FSE accounts for 25% of all childhood SE and for more than 70% of SE cases that occur in the second year of life. FSE is associated with increased epilepsy risk, particularly temporal lobe epilepsy (TLE).

"One aim of the FEBSTAT study is to determine the frequency of HHV-6A, HHV-6B, and HHV-7 as a cause of FSE and whether infection with any of these herpesviruses increases the risk of brain injury and epilepsy," said lead author Dr. Leon Epstein a, pediatric neurologist at the Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago.

The team enrolled 199 children between the ages of 1 month and 5 years, who presented with FSE and received an assessment for herpesvirus infection within 72 hours of the episode. Viremia was detected using polymerase chain reaction (PCR) that identified the presence of HHV-6A, HHV-6B or HHV-7A DNA and RNA. In conjunction with PCR results, researchers used antibody titers to determine if the infection was a primary or reactivated herpesvirus.

Findings indicate that approximately one third of children with FSE had HHV-6 or HHV-7 viremia. HHV-6B viremia was detected in 32% of pediatric participants, with 38 and 16 children having primary and reactivated infection, respectively. Researchers found that 7% of children had HHV-7 viremia at baseline and 2 children had HHV-6/7 primary co-infection. There were no apparent differences in age, illness type, fever, seizure structures, or acute imagining abnormalities in children with or without one of the herpesviruses.

FEBSTAT researchers will continue to follow the 199 children involved in the study, expecting up to 40% of this pediatric population to develop TLE. The FEBSTAT study will determine whether there is an association between prolonged febrile seizures caused by HHV-6B viremia and the development of TLE. The current study adds to evidence from previous research by Donati et al. and by Fotheringham et al who detected HHV-6 in brain samples of patients with TLE.

"TLE could take 8 to 11 years to develop following an episode of FSE, so more time is needed before the role of HHV-6B is fully understood," concludes Dr. Epstein. "If the FEBSTAT study finds that FSE caused by HHV-6B leads to TLE, this insight would provide a basis for clinical trials of antiviral and anti-inflammatory therapies to prevent TLE."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Leading childhood asthma group supports federal asthma action plan to reduce disparities
2. Folic acid food enrichment potentially protective against childhood cancers
3. Washington University receives $8 million to lead international childhood malnutrition effort
4. Prenatal exposure to air pollution linked to childhood obesity
5. Zip code as important as genetic code in childhood obesity
6. How many calories does it take to reach childhood obesity prevention goals?
7. Studies reveal structure of EV71, a virus causing childhood illnesses
8. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
9. Highly contagious honey bee virus transmitted by mites
10. To spread, nervous system viruses sabotage cell, hijack transportation
11. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... Feb. 8, 2017 About Voice Recognition Biometrics ... match it against a stored voiceprint template. Acoustic ... cadence, and tone are compared to distinguish between ... installation, as most PCs already have a microphone ... Voice recognition biometrics are most likely to be ...
(Date:2/8/2017)... 7, 2017 Report Highlights The ... from $8.3 billion in 2016 at a compound annual ... Report Includes - An overview of the global ... with data from 2015 and 2016, and projections of ... of the market on the basis of product type, ...
(Date:2/6/2017)... -- According to Acuity Market Intelligence, ongoing concerns ... continue to embrace biometric and digital identification based ... Control (ABC) eGates and 1436 Automated Passport Control ... ports of entry across the globe. Deployments increased ... CAGR of 37%. APC Kiosks reached 75% growth ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , ... February 23, 2017 ... ... announced today that in a published evaluation of multiple immunoassay-based threat detection ... Department of Energy Laboratory, PathSensors’ CANARY® biosensor threat detection technology was found ...
(Date:2/23/2017)... ... 2017 , ... Today, researchers can fast-track sample collection and ... other biomarkers or SNPs of interest) using one, easy-to-collect saliva sample. With the ... between insulin and other relevant biomarkers can be extensively studied through a non-invasive ...
(Date:2/23/2017)... Therapeutics, Inc. (NASDAQ: CAPR), a biotechnology company developing biological therapies ... Marbán, Ph.D, president and chief executive officer, is scheduled to ... Cowen and Company 37th Annual Health Care Conference Tuesday, March ... 29th Annual ROTH Conference Tuesday, ... Dana Point, CA ...
(Date:2/23/2017)... and SAN FRANCISCO , Feb. ... regenerative medicine company, and Beyond Type 1, a not-for-profit ... 1 diabetes, today announced a grant from Beyond Type ... cure for type 1 and other insulin-requiring diabetes.  ... been developing innovative stem cell-derived cell replacement therapies with ...
Breaking Biology Technology: