Navigation Links
Childhood trauma leaves its mark on the brain
Date:1/15/2013

It is well known that violent adults often have a history of childhood psychological trauma. Some of these individuals exhibit very real, physical alterations in a part of the brain called the orbitofrontal cortex. Yet a direct link between such early trauma and neurological changes has been difficult to find, until now.

Publishing in the January 15 edition of Translational Psychiatry, EPFL Professor Carmen Sandi and team demonstrate for the first time a correlation between psychological trauma in pre-adolescent rats and neurological changes similar to those found in violent humans.

"This research shows that people exposed to trauma in childhood don't only suffer psychologically, but their brain also gets altered," explains Sandi, Head of EPFL's Laboratory of Behavioral Genetics, Director of the Brain Mind Institute, and a member of the National Centers for Competence in Research SYNAPSY. "This adds an additional dimension to the consequences of abuse, and obviously has scientific, therapeutic and social implications."

The researchers were able to unravel the biological foundations of violence using a cohort of male rats exposed to psychologically stressful situations when young. After observing that these experiences led to aggressive behavior when the rats reached adulthood, they examined what was happening in the animals' brains to see if the traumatic period had left a lasting mark.

"In a challenging social situation, the orbitofrontal cortex of a healthy individual is activated in order to inhibit aggressive impulses and to maintain normal interactions," explains Sandi. "But in the rats we studied, we noticed that there was very little activation of the orbitofrontal cortex. This, in turn, reduces their ability to moderate their negative impulses. This reduced activation is accompanied by the overactivation of the amygdala, a region of the brain that's involved in emotional reactions." Other researchers who have
'/>"/>

Contact: Anne-Muriel Brouet
anne-muriel.brouet@epfl.ch
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bullying by childhood peers leaves a trace that can change the expression of a gene linked to mood
2. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
3. Abuse during childhood linked to adult-onset asthma in African-American women
4. Predicting the age at menopause of women having suffered from childhood cancers
5. Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
6. Single protein targeted as the root biological cause of several childhood psychiatric disorders
7. Antibiotic use in infants before 6 months associated with being overweight in childhood
8. School food -- on the front line in the fight against childhood obesity
9. Childhood obesity may affect timing of puberty, create problems with reproduction
10. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
11. Gene discovery set to help with mysterious paralysis of childhood
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Childhood trauma leaves its mark on the brain
(Date:9/30/2014)... do seedless watermelon, salmon, and strawberries all have in ... two sets of chromosomes and are diploid, these organisms ... sets of chromosomesseedless watermelon and salmon have 3 and ... While this might seem surprising, in fact most ... first discovered over a century ago, but only recently, ...
(Date:9/30/2014)... The National Institutes of Health (NIH) awarded ... to develop an electrode array system that will ... works through unprecedented resolution and scale. , LLNL,s ... support President Obama,s BRAIN (Brain Research through ... effort to revolutionize our understanding of the human ...
(Date:9/30/2014)... of environmental scientists and engineers, led by Clemson ... three-year, $5.25 million grant from the U.S. Department ... to make a direct positive impact on South ... disposal of radioactive contaminants. , "Understanding the scientific ... with environmental aspects of nuclear technologies is imperative ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... Remember frozen iguanas falling from trees during Florida,s 2010 ... at the University of Miami (UM) Rosenstiel School of Marine ... numbers due to the cold conditions. "It was a ... Rosenstiel School and lead author of the study. "Centuries-old coral ...
... helicopter parents who restrict their kids, unstructured play may ... latest issue of the American Journal of Play ... group of experts to probe the near-extinction of free ... "Remarkably, over the last 50 years, opportunities for children ...
... at Oregon State University have discovered that a freshwater species ... amphibian populations around the world. This tiny zooplankton, called ... for biological control of this deadly fungus, the scientists said, ... The fungus, B. dendrobatidis , is referred to ...
Cached Biology News:New study shows that Florida's reefs cannot endure a 'cold snap' 2Lack of free play among children is causing harm, say experts in American Journal of Play 2Possible biological control discovered for pathogen devastating amphibians 2
(Date:9/30/2014)... September 30, 2014 Applying a well-known optical ... at Harvard University has demonstrated the ability to ... work that holds promise for making future, flexible ... the sides of next-gen rocket ships and spacecraft ... passes through oil in water, it becomes iridescent, ...
(Date:9/30/2014)... Sept. 30, 2014 Report Details ... highest potential revenues Do you want to find ... you revenue predictions for those biological drugs from ... you find financial data, R&D trends, opportunities and ... sales forecasts to 2024 at overall world market, ...
(Date:9/30/2014)... Proove Biosciences , the commercial ... announce a new genetic test built upon research from ... Test will provide physicians with an objective way ... levels are stratified between individuals. With this new test, ... has a genetic predisposition that will affect their pain ...
(Date:9/30/2014)... Fast, semi-automatic creation of ... documents ChemAxon , a leader ... for life science research, launches ChemCurator, an application ... from documents. Markush structures are essential ... and understanding Markush structures is a difficult and ...
Breaking Biology Technology:Taking thin films to the extreme 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2
... ... partners to quickly and accurately forecast, plan and respond to ever-changing market demands, ManufacturingOne ... ... -- In response to a growing customer base in the high-tech manufacturing segment, ...
... ... while inviting others to join the cause for good science , ... CHAMPAIGN, IL and MELBOURNE, Australia (PRWEB) ... Web site, Academics Review , to examine claims against GM foods by Jeffrey ...
... ... guest speakers, everything sales and marketing professionals will need to pass the critical ... pipeline acceleration, inside sales, optimizing organizational structure and solutions-driven corporate/channel marketing – will ... ...
Cached Biology Technology:YASH Technologies™ Launches ManufacturingOne, a Qualified SAP Business All-in-One Partner Solution for the High-tech Manufacturing Industry 2YASH Technologies™ Launches ManufacturingOne, a Qualified SAP Business All-in-One Partner Solution for the High-tech Manufacturing Industry 3YASH Technologies™ Launches ManufacturingOne, a Qualified SAP Business All-in-One Partner Solution for the High-tech Manufacturing Industry 4Academics Launch New Web Site Holding Jeffrey Smith's Claims on GM Foods Up to Peer-Reviewed Science 2Academics Launch New Web Site Holding Jeffrey Smith's Claims on GM Foods Up to Peer-Reviewed Science 3Industry Leaders from Blue Coat, Oracle, Polycom, Siemens and Taleo Headline SiriusDecisions Sales and Marketing Summit 2010 2Industry Leaders from Blue Coat, Oracle, Polycom, Siemens and Taleo Headline SiriusDecisions Sales and Marketing Summit 2010 3Industry Leaders from Blue Coat, Oracle, Polycom, Siemens and Taleo Headline SiriusDecisions Sales and Marketing Summit 2010 4
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Desmosomal Protein Immunogen: Full length, native protein purified from human epidermal keratins. Storage: -20 C, Avoid Freeze/Thaw Cycles...
PPIF Antibody...
Biology Products: