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Childhood eye tumor made up of hybrid cells with jumbled development
Date:8/15/2011

nant cells. That result also sets the tumor apart from other cancers, which typically have a wider variety of genes switched on in tumor cells.

Scientists went on to show that blocking chemicals called monoamine neurotransmitters, which nerve cells normally use for communication, reduced growth in human retinoblastoma cells growing both in the laboratory and the eyes of mice. Dyer said the drugs used in this study, the anti-psychotic agents fluphenazine and chlorpromazine, better known as Thorazine, are unlikely to be used for treatment of retinoblastoma, but offer a starting point for future drug development.

The research also demonstrated that tumors transplanted directly from a patient into the same location in the eye of a mouse retained characteristics of the human tumor. The findings strengthen use of this approach for screening drugs for possible use against human cancers.


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Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

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