Navigation Links
Chemotherapy before radiotherapy for testicular cancer could reduce long-term side-effects
Date:8/16/2013

Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports. As many as 96% of men with testicular cancer now survive at least ten years from diagnosis (1), but more advanced forms need to be treated with combination chemotherapy which can have serious long-term complications. Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust have therefore been searching for new treatments that would reduce the risk of relapse after initial treatment and so spare as many men as possible from needing combination chemotherapy.

The new pilot study, published in the August issue of prestigious journal the Annals of Oncology, tested a new treatment in a pilot study of men with stage IIA and IIB testicular seminoma where the cancer has spread to the lymph nodes in the abdomen.

The researchers showed that giving chemotherapy drug carboplatin before radiotherapy could reduce relapse rates compared with radiotherapy alone cutting the numbers of men who would need follow-up treatment. It also allowed radiation doses to be reduced. The study was funded by The Institute of Cancer Research (ICR), the Bob Champion Cancer Trust and Cancer Research UK, as well as through the NIHR Biomedical Research Centre at The Royal Marsden and the ICR.

Researchers gave 51 men with stage IIA and IIB testicular seminoma a single cycle of carboplatin a low toxicity form of chemotherapy followed three to four weeks later by radiotherapy. Most of the men were aged below 50, over a range of 18-73 years.

Adding carboplatin to patients' treatment plans allowed doctors to give a lower dose of radiation over a smaller area of the body for most of the men in the study. Some 39 of the men in the study had their prescription of radiation reduced from the standard 35 Grays (Gy) of radiat
'/>"/>

Contact: Henry French
henry.french@icr.ac.uk
020-715-35312
Institute of Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Neuroblastoma: Autophagy protects from chemotherapy
2. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
3. Discovery may help prevent chemotherapy-induced anemia
4. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
5. New way to kill lymphoma without chemotherapy
6. Neutrons help explain why antibiotics prescribed for chemotherapy cause kidney failure
7. Scientists uncover strategy able to dramatically reduce chemotherapys side effects
8. New biomarker for common lung cancer predicts responses to chemotherapy
9. Nanobubbles plus chemotherapy equals single-cell cancer targeting
10. Harmless human virus may be able to boost the effects of chemotherapy
11. Hot flashes before menopause? It can happen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... near darkness use a previously unknown process for harvesting ... led by a Penn State University scientist has discovered. ... at improving plant growth, harvesting energy from the Sun, ... Lake Erie and other lakes worldwide. A paper describing ... Express edition of the journal Science ...
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... the journal Carcinogenesis by researchers at the ... protein adenomatous polyposis coli (APC) in suppressing colorectal cancer ... U.S. , Lead author Kristi Neufeld, associate professor in ... Cancer Biology program at the KU Cancer Center, has ... understand the various activities of APC, a protein whose ...
Breaking Biology News(10 mins):Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3
... This release is available in Spanish ... ideal for small gardens have been released by Agricultural ... are the latest cultivars released by ARS geneticist Sandy ... Plants Research Unit,s worksite in McMinnville, Tenn. The arboretum ...
... Landry,s Restaurants, Inc. (NYSE: LNY ) ("Landry,s" or ... Special Committee, made up of outside non-employee directors, and attorneys ... , Tilman J. Fertitta has reached a tentative ... claim and certain other claims in connection with Mr. Fertitta,s ...
... 27 DSW Inc. (NYSE: DSW ), a leading branded footwear ... through the first twelve weeks of fiscal 2010 ended April 24, 2010 . ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050629/CLW021LOGO ) , ... As a result, the Company now estimates annual comparable store ...
Cached Biology News:New hydrangea cultivars for landscape gardens 2Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 2Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 3Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 4DSW Inc. Raises Fiscal 2010 Annual Earnings Outlook 2DSW Inc. Raises Fiscal 2010 Annual Earnings Outlook 3
(Date:8/22/2014)... are intensively investigated for application as catalysts, ... and components in photonics and molecular electronics. ... for understanding physical and chemical properties, has ... USA, have demonstrated that high-resolution electron microscopy ... structure in which all gold atoms are ...
(Date:8/22/2014)... 22, 2014 The AMA is pleased ... members in Alaska that Alaska Governor Sean Parnell has ... further defining public use of Unmanned Aircraft Systems and ... House Bill 255states that it is, “An Act relating ... by an unmanned aircraft system.” It defines State of ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 DNA vaccine ... progress in its development of JRC-LAMP-vax, an innovative and ... pollen. Phase IC studies began this month in Hawaii, ... hay fever. , The Japanese red cedar releases pollen ... in Japan. Mountain Cedar pollen wreaks similar havoc in ...
(Date:8/21/2014)... August 21, 2014 His Majesty Willem-Alexander, ... , The Court of His Majesty Willem-Alexander, King of ... the Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY ... 3. , The King will take part in the ... scheduled for 11 a.m.-12:20 p.m. and tour the plant. ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Anacor Pharmaceuticals,announced today that it will ... and AN2898, at the upcoming,International Investigative Dermatology ... Kyoto, Japan. The IID Conference is the ... Dermatological Research (ESDR), the Japanese,Society for Investigative ...
... Limited (NYSE: MR ), a leading developer, manufacturer ... growing international,presence, today announced its selected unaudited financial results ... Highlights for First Quarter 2008 -- First quarter ... an increase of 48.2% over from ...
... Webcast and Conference Call Scheduled for Tuesday, May 13th at ... Therapeutics, Inc.,(Nasdaq: IMRX ) today announced that the Company ... 13, 2008, at 5:00 p.m. ET to discuss,first quarter 2008 ... ImaRx,s corporate website at, http://www.imarx.com and will be archived ...
Cached Biology Technology:Anacor to Present Clinical and Preclinical Data on Topical Anti-Inflammatory Candidates, AN2728 and AN2898, at the International Investigative Dermatology 2008 Conference 2Mindray Medical International Announces First Quarter 2008 Results 2Mindray Medical International Announces First Quarter 2008 Results 3Mindray Medical International Announces First Quarter 2008 Results 4Mindray Medical International Announces First Quarter 2008 Results 5Mindray Medical International Announces First Quarter 2008 Results 6Mindray Medical International Announces First Quarter 2008 Results 7Mindray Medical International Announces First Quarter 2008 Results 8Mindray Medical International Announces First Quarter 2008 Results 9Mindray Medical International Announces First Quarter 2008 Results 10Mindray Medical International Announces First Quarter 2008 Results 11Mindray Medical International Announces First Quarter 2008 Results 12Mindray Medical International Announces First Quarter 2008 Results 13Mindray Medical International Announces First Quarter 2008 Results 14Mindray Medical International Announces First Quarter 2008 Results 15Mindray Medical International Announces First Quarter 2008 Results 16Mindray Medical International Announces First Quarter 2008 Results 17Mindray Medical International Announces First Quarter 2008 Results 18
... INTERFERin is a new-generation siRNA transfection ... efficiency at 1 nM siRNA in a ... with excellent cell viability. Using low siRNA ... effects observed when transfecting siRNA at higher ...
... and Tissue Staining Kits are intended for ... of histological and cytological specimens. These kits ... manufactured by either R&D Systems or by ... the formation of the Avidin-Biotin Complex (ABC) ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
... is an easy-to-use siRNA transfection reagent that ... genes in a variety of cell lines. ... an optimized, straightforward protocol. High levels of ... following transfection of 20 to 100 nM ...
Biology Products: