Navigation Links
Chemists unlock potential target for drug development
Date:1/19/2012

EAST LANSING, Mich. -- A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.

A team led by Dana Spence of MSU's Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that impact red blood cells, such as diabetes, hypertension and cystic fibrosis.

Researchers can evaluate the receptor not only in developing new drugs but also re-testing existing medications that could work now by attaching to the receptor.

"Scientists are always looking for new 'druggable' receptors in the human body," Spence said. "This receptor, P2X1, has long been viewed as not important in platelets; our studies show that is not necessarily true. The receptor is very active; you just need to be careful in working with it."

The research is published in the current issue of Analytical Methods, a journal from the Royal Society of Chemistry in London.

The main job of platelets is to help prevent bleeding via clotting, Spence said. They work by getting sticky in the bloodstream, but the problem with some diseases such as diabetes or sickle-cell anemia is that the platelets get sticky even when they shouldn't, preventing proper blood flow and blocking vessels.

Platelets are activated when their receptors are "turned on"; currently, researchers have always focused on the P2Y receptor, which is easily studied. On the other hand, the P2X1 receptor was not thought to play a major role in platelet activation, and it proved very troublesome to study since it became desensitized once blood is drawn from the body, Spence said.

Though scientists tried a pair of methods to get around that issue by u
'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Chemists reveal the force within you
2. Clemson University biochemists identify new genetic code repair tool
3. Tel Aviv Universitys Sackler Prizes awarded to 2 North American chemists
4. K-State chemists biosensor may improve food, water safety and cancer detection
5. UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimers
6. Chemists turn gold to purple -- on purpose
7. Chemists document workings of key staph enzyme -- and how to block it
8. US launches International Year of Chemistry Feb. 1 with panel of world-renowned chemists
9. Chemists concoct new agents to easily study critical cell proteins
10. Team of chemists produces biodiesel at their university, using used cooking oil as a basis
11. Brown University chemists simplify biodiesel conversion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists unlock potential target for drug development
(Date:4/23/2014)... used to read quickly. It involves visual searching ... and/ or sentences. Similarly to humans, biological systems ... genetic information. Genes that need to be read ... encoding message, the easier it will be to ... de Cincia (IGC, Portugal) and Centre for Molecular ...
(Date:4/22/2014)... There,s a new secret to get your child to behave ... , A new Cornell study published in Eating Behaviors ... they had to bite with their front teeth such as ... rowdier than when these foods had been cut. ... as aggressive toward other kids," said Brian Wansink, Professor and ...
(Date:4/22/2014)... interim director of the University of Montana,s Wildlife Biology Program, ... Proceedings of the National Academy of Sciences on how ... ... Survey, the University of Washington, the Cary Institute of Ecosystem ... Northern Research Station examined 664 water samples collected every 10 ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Biting vs. chewing 2New research focuses on streamwater chemistry, landscape variation 2
... a summit on managing extreme events held last month in ... and the Willis Research Network, part of Willis Group Holdings, ... pledged to continue exploring activities aimed at increasing the physical ... 2011 has been a notable year for the high human ...
... ALBANY, N.Y., Oct. 18, 2011 When North Carolina,s "Laura,s ... state became the 8th state in the last year to ... of DUI laws from penalizing cars to required—and enforced—sobriety for ... is poised to join the movement, as state lawmakers look ...
... KENYA (14 October 2011) On a continent battered by ... released today from the World Agroforestry Centre documents an ... poor farmers in Southern Africa are now significantly boosting ... and shrubs to naturally fertilize their fields. The ...
Cached Biology News:US science academy and global reinsurance broker spark 2US science academy and global reinsurance broker spark 3US science academy and global reinsurance broker spark 4Are Alcohol Anklets the New Ignition Interlock? 2Are Alcohol Anklets the New Ignition Interlock? 3Are Alcohol Anklets the New Ignition Interlock? 4400,000 farmers in southern Africa using 'fertilizer trees' to improve food security 2400,000 farmers in southern Africa using 'fertilizer trees' to improve food security 3
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... conjugates for cancer, today announced the appointment of Thomas C ... has over 20 years, development experience gained in the biotechnology ... "I am delighted to welcome Tom at this ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... , BUDAPEST, Hungary, October 9 ... General of the Commission of,the European Communities approved the ... Consortium (CancerGrid) to,TargetEx. , "This ... in,Hungary - "and an appreciation of our scientific potential ...
... Accuray Incorporated (Nasdaq: ARAY ), a global leader ... Analyst Meeting in Chicago, Ill., on Monday, November 2, 2009 ... with the 51st Annual Meeting of the American Society for ... the presentation will be available online from the Investor Relations ...
... 8 Deloitte Recap LLC (Recap) has launched the ... Deloitte, a new subscription service that provides analytical tools ... strategy, financial, legal, tax and R&D professionals. Each product ... needs to offer the right business intelligence tools for ...
Cached Biology Technology:TargetEx Leads the European Cancer Research Consortium 2Accuray Incorporated to Host Investor and Analyst Meeting at ASTRO 2Deloitte Recap Launches New Series of Biopharmaceutical Business Intelligence Tools 2
For the quantitative determination of canine Interleukin 10,(IL-10) concentrations in cell culture supernates, canine serum,and plasma....
RAT ANTI RAT RT1Au (CLASS I POLYMORPHIC) Immunogen: AO lymphoid cells...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
Biology Products: