Navigation Links
Chemists reveal the force within you
Date:11/9/2011

normal cells, and it is unclear whether that difference is a cause or an effect of the disease.

"It's known that if EGFR is over-active, that can lead to cancer," Salaita says. "And one of the ways that EGFR is activated is by binding its ligand and taking it in. So if we can understand how tugging on EGFR force changes the pathway, and whether it plays a role in cancer, it might be possible to design drugs that target this pulling process."

Several methods have been developed in recent years to try to study the mechanics of cellular forces, but they have major limitations.

One genetic engineering approach requires splitting open and modifying proteins of a cell. This invasive technique may change the behavior of the cell, skewing the results.

The technique developed at Emory is non-invasive, does not modify the cell, and can be done with a standard florescence microscope. A flexible polymer is chemically modified at both ends. One end gets a florescence-based turn-on sensor that will bind to a receptor on the cell surface. The other end is chemically anchored to a microscope slide and a molecule that quenches fluorescence.

"Once a force is applied to the polymer, it stretches out," Salaita explains. "And as it extends, the distance from the quencher increases and the fluorescent signal turns on and grows brighter. We can determine the force being exerted by measuring the amount of fluorescent light emitted."

The forces of any individual protein or molecule on the cell surface can be measured using the technique, at far higher spatial and temporal resolutions than was previously possible.

Many mysteries beyond the biology and chemistry of cells may be explained through measuring cellular forces. How does a cancer cell crawl when a tumor spreads? What are the forces involved in cell division and immune response? What are the mechanics that allow groups of cardiac cells to beat in unison?

"O
'/>"/>

Contact: Beverly Clark
beverly.clark@emory.com
404-712-8780
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Clemson University biochemists identify new genetic code repair tool
2. Tel Aviv Universitys Sackler Prizes awarded to 2 North American chemists
3. K-State chemists biosensor may improve food, water safety and cancer detection
4. UCSB chemists make discovery that may lead to drug treatment possibilities for Alzheimers
5. Chemists turn gold to purple -- on purpose
6. Chemists document workings of key staph enzyme -- and how to block it
7. US launches International Year of Chemistry Feb. 1 with panel of world-renowned chemists
8. Chemists concoct new agents to easily study critical cell proteins
9. Team of chemists produces biodiesel at their university, using used cooking oil as a basis
10. Brown University chemists simplify biodiesel conversion
11. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... for Bone and Mineral Research awarded Michael F. Holick, ... with the 2014 Louis V. Avioli Award. Holick, a ... internationally known for revolutionizing the understanding of vitamin D ... award honors a member of the American Society for ... bone and mineral basic research. It is named for ...
(Date:7/11/2014)... the National Institute of Standards and Technology (NIST) ... more effectively, they often prove that necessity is ... case recently for M. Lorna De Leoz and ... specialization of glycomics. Glycomics is the study of ... are attached to proteins and lipids and influence ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2A first direct glimpse of photosynthesis in action 2
... With fewer than a dozen flowering plants out of 300,000 ... need to tap unused plants to feed the world in ... in the Comment feature of the July 4 issue of ... and rising incomes around the world, researchers estimate that food ...
... of Toronto-based researchers may be one step closer to a ... research and therapy. Induced pluripotent stem cells (iPSCs) can ... flexibly develop into many different types of cells. However, producing ... generation are largely unknown. But researchers from the University ...
... A new study published today in the journal ... the Australian, Antarctic and Indian tectonic plates, demonstrating how ... Researchers from Royal Holloway University, The Australian National ... uncertainties on how the plates evolved and where they ...
Cached Biology News:To feed the future, we must mine the wealth of the world's seed banks today 2Toronto team ID proteins key in stem cell production 2
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
(Date:7/10/2014)... research may help in the fight against terrorism with ... quantities of explosives with the use of light and ... Sensors and Actuators B: Chemical , the researchers describe ... in concentrations as low as 6.3 ppm (parts per ... few minutes. , "Traditionally explosives detection has involved looking ...
(Date:7/10/2014)... Hall effect in bilayer graphene and shown that this ... electric field. , The fractional quantum Hall effect, ... are exposed to large magnetic fields, is a striking ... behave as a single system. However, while the basic ... of this collective behavior remain not well understood, in ...
(Date:7/10/2014)... study by researchers at the University of Illinois ... mechanisms governing the interplay of spin and heat ... of ultrafast spintronic devices for data storage and ... as well as spin-angular momentum. In a typical ... is no spin current," explained David Cahill, a ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2
... East/Africa and Canada -, COLLEGEVILLE, Pa., June ... WYE ), announced today the,appointment of Andreas ... effective immediately. In this new role, Mr. Krebs ... Pharmaceuticals, and Senior Vice,President, Wyeth., Mr. Krebs ...
... to take a more proactive approach ... assessment of drug safety information, HYDERABAD, India ... Services Ltd. (NYSE: SAY ), a leading ... that it has,formed an alliance with Sciformix Corporation, ...
... Md., June 26 Pinnacle Biologics, a private,full ... it has entered into a preferred stock purchase ... acquired certain,unspecified number of preferred stock shares of ... not disclosed., Pinnacle Biologics owns the marketing ...
Cached Biology Technology:Satyam Forms Partnership with Sciformix to Provide Comprehensive Drug Safety Management 2Satyam Forms Partnership with Sciformix to Provide Comprehensive Drug Safety Management 3Satyam Forms Partnership with Sciformix to Provide Comprehensive Drug Safety Management 4