Navigation Links
Chemists make beds with soft landings
Date:8/17/2008

Laskin and Wang began with peptides made almost entirely of the amino acid alanine. Due to alanine's chemical nature, long chains of it naturally form so-called α helices. The researchers ended the alanine chain with the amino acid lysine, which stabilizes the helix and allows the coiled chain to be chemically attached to the surface.

Working with a specially designed mass-selected ion deposition instrument at DOE's Environmental Molecular Sciences Laboratory on the PNNL campus, they deposited the peptides on the support layer in one of two ways, starting either from a liquid form for electrospray or from a gaseous mixture for soft-landing. In each case, the chemists began with the peptides (either in liquid or gas), zapped them to give them a slight electrical charge and blew them onto the surface.

When the chemists examined the peptide shapes in the solution and the resulting thin film, they found, unexpectedly, that most of the peptides failed to form helices. Instead, the majority of peptides took on a flat shape known as a β sheet. The dearth of helices in liquid form surprised the researchers.

When the researchers next used soft-landing to form thin layers, they didn't know if the peptides would form helices before landing on the surface. "Because we were starting from something that wasn't α-helical in solution, we were a little pessimistic whether it would work at all," Wang said.

But work it did. Depositing the peptides with soft-landing, the chemists found that nearly all of them alighted as helices. In addition, they could chemically connect the helices to the surface using a related technique called reactive-landing. When the chemists treated the thin layer with sound waves to test how easily the peptides fell off or changed shape, they found that some loosely bound peptides fell off, but those remaining maintained their helical forms.

"They formed a nicely organized, beautiful layer," says
'/>"/>

Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. NIST chemists get scoop on crude oil from pig manure
2. Glowing films developed by UC San Diego chemists reveal traces of explosives
3. Biologists are from Mars, chemists are from Venus?
4. Biochemists reveal details of mysterious bacterial microcompartments
5. Team of chemists receives $5 million grant to develop enzyme mimics
6. Good earth: Brown chemists show origin of soil-scented geosmin
7. Chemists get grip on slippery lipids
8. Clemson chemists discover new way antioxidants fight debilitating diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists make beds with soft landings
(Date:4/15/2014)... professor of mechanical engineering at Worcester Polytechnic ... university,s Integrative Materials Design Center (iMdc), recently ... leading engineering societies. , At its annual ... association of more than 138,000 engineers and ... and commercial vehicle industries, presented Lados with ...
(Date:4/15/2014)... Texas The global experts who study the deadliest ... and Thomas G. Ksiazek, professors at the University of ... the 6th annual International Symposium on Filoviruses. The filoviruses ... 50 to 90 percent of people infected. The current ... caused more than 100 deaths so far. , ...
(Date:4/15/2014)... (April 15, 2014) The American Association of ... winners. All awards will be presented during the ... Marriott Hotel on Tuesday, April 29th at 7:30 p.m. ... , The 2014 award winners are: ... Laitman, PhD, of the Icahn School of Medicine at ...
Breaking Biology News(10 mins):WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 2WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 3WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 4WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 5International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3American Association of Anatomists 2014 award winners 2
... mothers can survive over the long-term, according to new research ... . The study shows for the first time that some ... led by a Field Museum scientist working with numerous colleagues ... shark producing multiple offspring that survived. Two daughters of the ...
... Press, and the Infectious Diseases Society of America (IDSA), ... partnership for IDSA,s highly cited and internationally prestigious journals: ... The Journal of Infectious Diseases ( JID ... from 1st of January, 2011. IDSA,s ...
... that live in the mountains are highly likely to die ... relatives in the lowlands are not, according to new research ... of the study, from Imperial College London, the Zoological Society ... suggest conservationists may be able to limit the impact of ...
Cached Biology News:Study of shark virgin birth shows offspring can survive long term 2Oxford University Press enters publishing partnership with Infectious Diseases Society of America 2Living the high life is risky business for toads under threat from fungus 2Living the high life is risky business for toads under threat from fungus 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Non-GAAP EPS Increased 22 Percent, CAMBRIDGE, Mass., April 23 ... the first quarter of,2008, which featured excellent revenue growth, continued ... the company., First-Quarter Highlights -- Total revenue ... $883.2 million in same period a ...
... patients treated with PBI-1402 did not require blood ... ... ProMetic Life Sciences Inc.,(TSX: PLI) ("ProMetic") announces that oral PBI-1402 demonstrates,significant ... red blood cell ("RBC") transfusion., Only 2 patients out of ...
... PCOP ), an innovator in the discovery and development ... plans to,release its financial results for the first quarter ... Wednesday, May 7, 2008. The company will,conduct a webcast ... same day., Dr. Joseph A. Mollica, Chairman of ...
Cached Biology Technology:Genzyme Reports Strong First-Quarter Growth 2Genzyme Reports Strong First-Quarter Growth 3Genzyme Reports Strong First-Quarter Growth 4Genzyme Reports Strong First-Quarter Growth 5Genzyme Reports Strong First-Quarter Growth 6Genzyme Reports Strong First-Quarter Growth 7Genzyme Reports Strong First-Quarter Growth 8Genzyme Reports Strong First-Quarter Growth 9Genzyme Reports Strong First-Quarter Growth 10Genzyme Reports Strong First-Quarter Growth 11Genzyme Reports Strong First-Quarter Growth 12Genzyme Reports Strong First-Quarter Growth 13Genzyme Reports Strong First-Quarter Growth 14Genzyme Reports Strong First-Quarter Growth 15Genzyme Reports Strong First-Quarter Growth 16Genzyme Reports Strong First-Quarter Growth 17Genzyme Reports Strong First-Quarter Growth 18Genzyme Reports Strong First-Quarter Growth 19Oral PBI-1402 Demonstrates Significant Activity in Chemotherapy-Induced Anemia Phase II Clinical Trial 2Oral PBI-1402 Demonstrates Significant Activity in Chemotherapy-Induced Anemia Phase II Clinical Trial 3Pharmacopeia to Host First Quarter 2008 Financial Results Webcast and Conference Call 2Pharmacopeia to Host First Quarter 2008 Financial Results Webcast and Conference Call 3
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
...
Biology Products: