Navigation Links
Chemists make beds with soft landings
Date:8/17/2008

Laskin and Wang began with peptides made almost entirely of the amino acid alanine. Due to alanine's chemical nature, long chains of it naturally form so-called α helices. The researchers ended the alanine chain with the amino acid lysine, which stabilizes the helix and allows the coiled chain to be chemically attached to the surface.

Working with a specially designed mass-selected ion deposition instrument at DOE's Environmental Molecular Sciences Laboratory on the PNNL campus, they deposited the peptides on the support layer in one of two ways, starting either from a liquid form for electrospray or from a gaseous mixture for soft-landing. In each case, the chemists began with the peptides (either in liquid or gas), zapped them to give them a slight electrical charge and blew them onto the surface.

When the chemists examined the peptide shapes in the solution and the resulting thin film, they found, unexpectedly, that most of the peptides failed to form helices. Instead, the majority of peptides took on a flat shape known as a β sheet. The dearth of helices in liquid form surprised the researchers.

When the researchers next used soft-landing to form thin layers, they didn't know if the peptides would form helices before landing on the surface. "Because we were starting from something that wasn't α-helical in solution, we were a little pessimistic whether it would work at all," Wang said.

But work it did. Depositing the peptides with soft-landing, the chemists found that nearly all of them alighted as helices. In addition, they could chemically connect the helices to the surface using a related technique called reactive-landing. When the chemists treated the thin layer with sound waves to test how easily the peptides fell off or changed shape, they found that some loosely bound peptides fell off, but those remaining maintained their helical forms.

"They formed a nicely organized, beautiful layer," says
'/>"/>

Contact: Mary Beckman
mary.beckman@pnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. NIST chemists get scoop on crude oil from pig manure
2. Glowing films developed by UC San Diego chemists reveal traces of explosives
3. Biologists are from Mars, chemists are from Venus?
4. Biochemists reveal details of mysterious bacterial microcompartments
5. Team of chemists receives $5 million grant to develop enzyme mimics
6. Good earth: Brown chemists show origin of soil-scented geosmin
7. Chemists get grip on slippery lipids
8. Clemson chemists discover new way antioxidants fight debilitating diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists make beds with soft landings
(Date:9/18/2014)... Clownfish spend their entire lives nestling in the protective ... as babies they sometimes travel hundreds of kilometres across ... by reef fish has been predicted, this is the ... between distant populations has been observed. , Dr Steve ... at the University of Exeter, and colleagues from the ...
(Date:9/17/2014)... Europaea started in 2000 as an EC-FP5 four-year project, ... of steady progress and successful participations in several EC ... Biodiversity Observation Network project (EU BON), to increase ... contributors and to extend the general dissemination of the ... has applied its novel e-Publishing tools to ...
(Date:9/17/2014)... (Hospital del Mar Medical Research Institute) and at the ... study in eLife showing that RNA called ... of new proteins, some of which could have important ... from the instructions found in an RNA molecule. However, ... information for the synthesis of proteins, meaning it is ...
Breaking Biology News(10 mins):Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Parts of genome without a known function may play a key role in the birth of new proteins 2
... evidence that Parkinson,s disease may have an infectious or ... is associated with late-onset sporadic Parkinson,s disease" appears online ... conducted by the NeuroGenetics Research Consortium, an international team ... the New York State Department of Health Wadsworth Center. ...
... State University have developed a method for predicting the ... the human body. Their work could have implications for ... of nanomaterials, as well as applications for drug delivery. ... Distinguished Professor of Pharmacology and director of the ...
... SALT LAKE CITY, July 26 Wall Street Communications ... Media, a world leader in content identification solutions, to ... a presence for the company in broadcast, government, and ... Media, based in Darmstadt, Germany, is a spinoff of ...
Cached Biology News:Researchers discover genetic link between immune system, Parkinson's disease 2Probing the nanoparticle: Predicting how nanoparticles will react in the human body 2Wall Street Communications Retained by iPharro Media 2
(Date:9/18/2014)... (PRWEB) September 18, 2014 Texas ... John Sharp, Texas A&M Health Science Center CEO ... Department of Health and Human Services (HHS), State ... a national pandemic influenza vaccine manufacturing facility in ... an anchor for the Texas A&M Biocorridor – ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... are undifferentiated biological cells that can differentiate into specialized ... stem cells. Stem cell therapy can be applied to ... system disease), nervous system diseases, damage or lesion of ...
(Date:9/18/2014)... Research and Markets has announced ... Report 2014" report to their offering. ... a professional and in-depth study on the current state ... report provides a basic overview of the industry including ... albumin market analysis is provided for the international markets ...
(Date:9/18/2014)... 18, 2014 Leatherwood Plastics has ... material, to stay competitive in the semiconductor, clean ... materials ultimately impact product quality and productivity, according ... , Established in 1980 in Lewisville, TX, ... fabricators have left the business. Much of Leatherwood’s ...
Breaking Biology Technology:Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... , BALTIMORE, Sept. 10 ... company whose personalized oncology services division assists physicians by providing ... a collaboration agreement with PinnacleCare , the ... world. , , PinnacleCare will offer Champions, ...
... , SAN DIEGO, Sept. 10 ... 2b clinical trial with Aeroquin((R)) (a novel aerosol formulation of ... that nebulized Aeroquin met the primary endpoint of reducing bacterial ... in sputum after 28 days of dosing versus placebo. ...
... , NEW HAVEN, Conn., Sept. ... a development-stage company focused on the discovery, development and ... care antibiotic-resistant infections, today announced that seven posters have ... on Antimicrobial Agents and Chemotherapy (ICAAC) taking place in ...
Cached Biology Technology:Champions Biotechnology and PinnacleCare Enter Into Personalized Oncology Collaboration Agreement 2Champions Biotechnology and PinnacleCare Enter Into Personalized Oncology Collaboration Agreement 3Champions Biotechnology and PinnacleCare Enter Into Personalized Oncology Collaboration Agreement 4Mpex Pharmaceuticals Announces Positive Phase 2b Clinical Trial Results with Aeroquin(R) (MP-376) Treatment in Cystic Fibrosis Patients 2Mpex Pharmaceuticals Announces Positive Phase 2b Clinical Trial Results with Aeroquin(R) (MP-376) Treatment in Cystic Fibrosis Patients 3Mpex Pharmaceuticals Announces Positive Phase 2b Clinical Trial Results with Aeroquin(R) (MP-376) Treatment in Cystic Fibrosis Patients 4Rib-X Pharmaceuticals to Present at the 49th ICAAC 2Rib-X Pharmaceuticals to Present at the 49th ICAAC 3Rib-X Pharmaceuticals to Present at the 49th ICAAC 4
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic gel acid stain has also found ... bandshift assays. One mL stains 100 minigels. A ...
Synonym: modified Grace's Insect medium...
... acid synthetic peptide whose sequence is derived from bovine rhodopsin ... carboxy terminus): C - S(338) - K - T ... - A - P - A(348). This peptide ... polyclonal antibody that reacts with this product and bovine rhodopsin, ...
... The proteomic service includes protein ... analysis using the PDQuest software package ... MALDI-TOF mass spectrometry. In order to ... sample preparation, data analysis and format ...
Biology Products: