Navigation Links
Chemists influence stem-cell development with geometry
Date:3/17/2010

University of Chicago scientists have successfully used geometrically patterned surfaces to influence the development of stem cells. The new approach is a departure from that of many stem-cell biologists, who focus instead on uncovering the role of proteins in controlling the fate of stem cells.

"The cells are seeing the same soluble proteins. In both cases it's the shape alone that's dictating whether they turn into fat or bone, and that hasn't been appreciated before," said Milan Mrksich, Professor in Chemistry and a Howard Hughes Medical Institute Investigator, who led the study. "That's exciting because stem-cell therapies are of enormous interest right now, and a significant effort is ongoing to identify the laboratory conditions that can take a stem cell and push it into a specific lineage."

The UChicago team found that making cells assume a star shape promotes a tense cytoskeleton, which provides structural support for cells, while a flower shape promotes a looser cytoskeleton. "On a flower shape you get the majority of cells turning to fat, and on a star shape you've got the majority of cells turning into bone," said Kris Kilian, a National Institutes of Health Fellow in Mrksich's research group. The UChicago team published its findings in the March 1 Early Edition of the Proceedings of the National Academy of Sciences.

Mrksich cautioned that the method is far from ready for use in the harvest of stem cells for therapeutic use, but it does signal a potentially promising direction for further study.

Mrksich's research group has a long history of developing methods for patterning surfaces with chemistry to control the positions, sizes and shapes of cells in culture, and applying those patterned cells to drug-discovery assays, and studies of cell migration and cell adhesion.


'/>"/>

Contact: Steve Koppes
s-koppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1

Related biology news :

1. Behavior of single protein observed in unprecedented detail by Stanford chemists
2. UNH chemists create molecule with promising semiconductor properties
3. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
4. U of C chemists discover recipe to design a better type of fuel cell
5. Dancing adatoms help chemists understand how water molecules split
6. UConn chemists find secret to increasing luminescence efficiency of carbon nanotubes
7. Clemson chemists present revolutionary teaching concepts
8. JHU chemists devise self-assembling organic wires
9. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
10. Smoke smudges Mexico Citys air, chemists identify sources
11. Biochemists manipulate fruit flavor enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists influence stem-cell development with geometry
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
(Date:2/28/2017)... Germany , February 28, 2017 News ... ... Amsterdam from 14 to 16 March, Materna ... destination, and show how seamless travel is a real benefit for ... has added biometrics to their passenger touch point solutions to take ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader of ... elite iris biometric solution on the latest Qualcomm® ... at Mobile World Congress 2017 (February 27 ... in Hall 3, Stand 3E10. ... Haven™ security platform—a combination of hardware, software ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... 29, 2017 , ... ComplianceOnline, the leading governance, risk and compliance advisory network ... Device Summit 2017 venue and speaker lineup. The Summit will take place on June ... The Omni Parker House Hotel, which is located at 60 School Street, Boston, MA ...
(Date:3/29/2017)... 2017  Halozyme Therapeutics, Inc. (NASDAQ: HALO), a ... today announced that an Oncologic Drug Advisory Committee ... 11 to 0 that the benefit/risk of rituximab/hyaluronidase ... for patients in the proposed indications of follicular ... leukemia. The FDA action date is June 26, ...
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... edge instrumentation for cell-based assays, disperses a quarterly travel award to noteworthy scientists ... Today the company announced that its new round of awards are being given ...
(Date:3/29/2017)... ... March 29, 2017 , ... Bactana Animal Health, a company developing natural products ... through enhancement of the gut microbiota, today announced the closing of its first round ... York-based Sustainable Income Capital Management, LLC and a number of private investors. The company ...
Breaking Biology Technology: