Navigation Links
Chemists influence stem-cell development with geometry
Date:3/17/2010

University of Chicago scientists have successfully used geometrically patterned surfaces to influence the development of stem cells. The new approach is a departure from that of many stem-cell biologists, who focus instead on uncovering the role of proteins in controlling the fate of stem cells.

"The cells are seeing the same soluble proteins. In both cases it's the shape alone that's dictating whether they turn into fat or bone, and that hasn't been appreciated before," said Milan Mrksich, Professor in Chemistry and a Howard Hughes Medical Institute Investigator, who led the study. "That's exciting because stem-cell therapies are of enormous interest right now, and a significant effort is ongoing to identify the laboratory conditions that can take a stem cell and push it into a specific lineage."

The UChicago team found that making cells assume a star shape promotes a tense cytoskeleton, which provides structural support for cells, while a flower shape promotes a looser cytoskeleton. "On a flower shape you get the majority of cells turning to fat, and on a star shape you've got the majority of cells turning into bone," said Kris Kilian, a National Institutes of Health Fellow in Mrksich's research group. The UChicago team published its findings in the March 1 Early Edition of the Proceedings of the National Academy of Sciences.

Mrksich cautioned that the method is far from ready for use in the harvest of stem cells for therapeutic use, but it does signal a potentially promising direction for further study.

Mrksich's research group has a long history of developing methods for patterning surfaces with chemistry to control the positions, sizes and shapes of cells in culture, and applying those patterned cells to drug-discovery assays, and studies of cell migration and cell adhesion.


'/>"/>

Contact: Steve Koppes
s-koppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1

Related biology news :

1. Behavior of single protein observed in unprecedented detail by Stanford chemists
2. UNH chemists create molecule with promising semiconductor properties
3. Iowa State, Ames Lab chemists discover how antiviral drugs bind to and block flu virus
4. U of C chemists discover recipe to design a better type of fuel cell
5. Dancing adatoms help chemists understand how water molecules split
6. UConn chemists find secret to increasing luminescence efficiency of carbon nanotubes
7. Clemson chemists present revolutionary teaching concepts
8. JHU chemists devise self-assembling organic wires
9. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
10. Smoke smudges Mexico Citys air, chemists identify sources
11. Biochemists manipulate fruit flavor enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists influence stem-cell development with geometry
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces a presentation by ... Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
Breaking Biology Technology: