Navigation Links
Chemists get grip on slippery lipids
Date:8/30/2007

The ability of the body's cells to correctly receive and convey signals is crucial to good health.

Lipids, or fats, play a critical role in this regulation by providing spaces for proteins to gather and network. They are helped in this process by protein molecules called lipid binding domains.

Understanding how these domains work may open up new targets of opportunity for drug development to treat illnesses such as cancer, diabetes and various inflammatory diseases.

Studying lipid binding domains is a specialty of Wonhwa Cho, distinguished professor of chemistry at the University of Illinois at Chicago. In two recently released papers appearing in the EMBO Journal and the Journal of Biological Chemistry, Cho and his associates describe mechanisms by which a particular binding domain -- the PX or "Phox" -- recognize specific lipids and interact with cell membranes to modulate functions.

"The PX domain can recognize and interact with a large number of lipid molecules and other proteins," said Cho. "We study how particular types of PX domains recognize specific lipids."

In the papers, Cho describes the structure and function PX domains from two proteins, KIF16B and Bem1p, which interact with a class of signaling lipids called phosphoinositides.

"KIF16B-PX domain is a critical component of the regulatory mechanism to modulate the duration of receptor-mediated cell signaling pathways," Cho said. "That's important because both prolonged and shortened signaling pathways will cause problems."

"Bem1p-PX domain is a yeast scaffold protein that's critical for cell polarity. It serves as an excellent model system to study how a scaffold protein goes to the cell membrane in response to a particular lipid signal, and then modulates multiple protein-protein interactions."

Cho's research group pioneered a novel biophysical approach to explain the complex mechanisms by which cellular lipid signals specifi
'/>"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Chemists identify key gene in development of type 1 diabetes
4. Chemists identify immune system mechanism for methamphetamine binges
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Red delicious, Northern Spy apples have most antioxidants, chemists find
7. Chemists synthesize molecule that helps body battle cancers, malaria
8. NYU chemists use computer simulation to enhance understanding of DNA transcription
9. Sticky surfaces turn slippery with the flip of a molecular light switch
10. Interfering RNA silences genes in slippery immune cells
11. Scientists discover that host cell lipids facilitate bacterial movement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Migration negation 2Migration negation 3
... ROCKVILLE, Maryland July 9, 2009 Human Genome ... New England Journal of Medicine of the ... the life-saving potential of the Company,s human monoclonal antibody ... human safety studies, which supported the use of raxibacumab ...
... conducted at the University of Houston may offer important ... levels and help regulators determine whether existing fish-consumption advisories ... way, the UH engineering team,s project is entering a ... from Galveston Bay and related waterways. Cullen ...
... appearing in Environmental Health Perspectives (EHP) ... for the Project on Emerging Nanotechnologies (PEN), focuses ... It provides an overview of current practices; ... safety implications; and possible future directions for nanoremediation. ...
Cached Biology News:Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax 2UH team analyzes Hurricane Ike's effects on waterways, fish contamination 2UH team analyzes Hurricane Ike's effects on waterways, fish contamination 3Contaminated site remediation: Are nanomaterials the answer? 2
(Date:11/26/2014)... SonaCare Medical, a leading manufacturer ... recently participated in the American Urology Association’s (AUA) ... Key opinion leaders in urology presented on the ... renal masses while attendees had the opportunity to ... hands-on labs. Attendees at the Los Angeles, CA ...
(Date:11/26/2014)... November 25, 2014 Global biostimulants ... 2019 growing at an estimated CAGR of 12.5%. ... healthy food products with least ecological impacts, farmers ... fertilizers to boost crop yield more effectively & ... that can improve the return on investments. , ...
(Date:11/26/2014)... 2014 Deep Research Report on Global ... on the Global Palmitic Acid industry. For an ... information, including definition, classification, application, industry chain structure, ... , For international and China market analysis, ... in China and other countries or regions by ...
(Date:11/26/2014)... N.J. , Nov. 25, 2014  Roka Bioscience, Inc. ... on providing advanced testing solutions for the detection of foodborne ... present at the Piper Jaffray  26 th Annual Healthcare ... will be held at The New York Palace in ... this presentation, material information concerning the Company, its operations, strategies ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2
... added four, six and eight port right-angle BNC connectors to its ... savings as a replacement for applications where a number of single ... ... Sunnyvale, CA (PRWEB) April 29, 2009 -- Regal Electronics ...
... - 4TB4Free , ... Austin, Texas (PRWEB) April 29, ... for accessing, storing and distributing content, today announced the release of ... can run virtual CAStor nodes in a single, physical server chassis. ...
... MEDX ) is scheduled to host a ... Time on Thursday, April 30, 2009 to review Medarex,s ... of 2009.To access the call live, please dial 1-877-397-0272 ... through the Investor Relations section of Medarex,s website at ...
Cached Biology Technology:Regal Introduces Four, Six and Eight Port Filtered and Un-Filtered Right Angle BNC Connectors 2Caringo Delivers Storage Cluster in a Box with CAStor 3.0 2Medarex to Host Business and Financial Update Conference Call on Thursday, April 30, 2009 2
... Directly compatible with ABI thermal cyclers, QPCR ... sealing characteristics can be sealed with ... strips, Certified free of DNase, RNase and ... Thermo Fisher Scientific, the world leader in ...
BD BioCoat Vented Caps for 175 cm2 Flasks...
I-Ab MHC Class II...
... BioCoat Collagen I 60 mm Culture Dishes ... tissue-culture treated polystyrene with a uniform application of ... : Collagen I ,Surface : ... cm2 ,Dim nominal : 60 mm ...
Biology Products: