Navigation Links
Chemists get grip on slippery lipids
Date:8/30/2007

The ability of the body's cells to correctly receive and convey signals is crucial to good health.

Lipids, or fats, play a critical role in this regulation by providing spaces for proteins to gather and network. They are helped in this process by protein molecules called lipid binding domains.

Understanding how these domains work may open up new targets of opportunity for drug development to treat illnesses such as cancer, diabetes and various inflammatory diseases.

Studying lipid binding domains is a specialty of Wonhwa Cho, distinguished professor of chemistry at the University of Illinois at Chicago. In two recently released papers appearing in the EMBO Journal and the Journal of Biological Chemistry, Cho and his associates describe mechanisms by which a particular binding domain -- the PX or "Phox" -- recognize specific lipids and interact with cell membranes to modulate functions.

"The PX domain can recognize and interact with a large number of lipid molecules and other proteins," said Cho. "We study how particular types of PX domains recognize specific lipids."

In the papers, Cho describes the structure and function PX domains from two proteins, KIF16B and Bem1p, which interact with a class of signaling lipids called phosphoinositides.

"KIF16B-PX domain is a critical component of the regulatory mechanism to modulate the duration of receptor-mediated cell signaling pathways," Cho said. "That's important because both prolonged and shortened signaling pathways will cause problems."

"Bem1p-PX domain is a yeast scaffold protein that's critical for cell polarity. It serves as an excellent model system to study how a scaffold protein goes to the cell membrane in response to a particular lipid signal, and then modulates multiple protein-protein interactions."

Cho's research group pioneered a novel biophysical approach to explain the complex mechanisms by which cellular lipid signals specifically and divergently activate a wide array of lipid binding domains and the proteins harboring these domains during various cellular processes.

"This research may help in development of new types of small molecules and drugs that specifically modulate the signaling and trafficking processes," Cho said. "For example, if a cellular malfunction is caused by over-activation of a particular lipid-mediated pathway, then we can turn off that pathway by developing a compound that interferes with the interaction of the lipid with its binding protein."


'/>"/>
Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Chemists identify key gene in development of type 1 diabetes
4. Chemists identify immune system mechanism for methamphetamine binges
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Red delicious, Northern Spy apples have most antioxidants, chemists find
7. Chemists synthesize molecule that helps body battle cancers, malaria
8. NYU chemists use computer simulation to enhance understanding of DNA transcription
9. Sticky surfaces turn slippery with the flip of a molecular light switch
10. Interfering RNA silences genes in slippery immune cells
11. Scientists discover that host cell lipids facilitate bacterial movement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... on quality, regulatory and technical consulting, provides a free webinar on ... on July 13, 2016 at 12pm CT at no charge. , Incomplete investigations ...
Breaking Biology Technology: