Navigation Links
Chemists get grip on slippery lipids
Date:8/30/2007

The ability of the body's cells to correctly receive and convey signals is crucial to good health.

Lipids, or fats, play a critical role in this regulation by providing spaces for proteins to gather and network. They are helped in this process by protein molecules called lipid binding domains.

Understanding how these domains work may open up new targets of opportunity for drug development to treat illnesses such as cancer, diabetes and various inflammatory diseases.

Studying lipid binding domains is a specialty of Wonhwa Cho, distinguished professor of chemistry at the University of Illinois at Chicago. In two recently released papers appearing in the EMBO Journal and the Journal of Biological Chemistry, Cho and his associates describe mechanisms by which a particular binding domain -- the PX or "Phox" -- recognize specific lipids and interact with cell membranes to modulate functions.

"The PX domain can recognize and interact with a large number of lipid molecules and other proteins," said Cho. "We study how particular types of PX domains recognize specific lipids."

In the papers, Cho describes the structure and function PX domains from two proteins, KIF16B and Bem1p, which interact with a class of signaling lipids called phosphoinositides.

"KIF16B-PX domain is a critical component of the regulatory mechanism to modulate the duration of receptor-mediated cell signaling pathways," Cho said. "That's important because both prolonged and shortened signaling pathways will cause problems."

"Bem1p-PX domain is a yeast scaffold protein that's critical for cell polarity. It serves as an excellent model system to study how a scaffold protein goes to the cell membrane in response to a particular lipid signal, and then modulates multiple protein-protein interactions."

Cho's research group pioneered a novel biophysical approach to explain the complex mechanisms by which cellular lipid signals specifi
'/>"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chemists create Superbowl molecule; May lead to better health
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Chemists identify key gene in development of type 1 diabetes
4. Chemists identify immune system mechanism for methamphetamine binges
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Red delicious, Northern Spy apples have most antioxidants, chemists find
7. Chemists synthesize molecule that helps body battle cancers, malaria
8. NYU chemists use computer simulation to enhance understanding of DNA transcription
9. Sticky surfaces turn slippery with the flip of a molecular light switch
10. Interfering RNA silences genes in slippery immune cells
11. Scientists discover that host cell lipids facilitate bacterial movement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... is available in French . , Montreal, ... products with folic acid has already proved to be effective ... the British Medical Journal by a group of ... (MAUDE Unit), the Research Institute of the McGill University Health ...
... a protein in fruit flies crucial to switch a stem ... to University of Oregon biochemists. They,ve found that one enzyme ... directs which roads daughter cells will take. "Wherever aPKC ... says Kenneth E. Prehoda, a professor in the chemistry department ...
... Trials Network, an initiative designed to address the ... of imaging biomarkers into multi-center clinical trials, recently ... the world,s largest medical and scientific society for ... in late 2008 to facilitate more cost-effective drug ...
Cached Biology News:Folic acid to prevent congenital heart defects 2How an enzyme tells stem cells which way to divide 2SNM's clinical trials network gains added support from industry leader 2
(Date:12/24/2014)... , Dec. 23, 2014  Rock Creek Pharmaceuticals, ... it has filed a Clinical Trial Application (CTA) with ... products Regulatory Agency (MHRA) seeking regulatory approval to initiate ... molecule, Anatabine Citrate. Contingent on the Company ... a Phase I trial to assess the safety, tolerability ...
(Date:12/22/2014)... HILL, N.C. , Dec. 22, 2014 /PRNewswire/ ... today announced that it has signed a letter ... company that has developed and patented a nanotechnology-based ... medical diagnostics products that enable rapid on-site collection ... alcohol use/abuse and health issues in an immediate, ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced ... , a network of more than 20 contributing ... have fast access to a national pool of frozen ... Fertility Associates of Memphis is the only fertility clinic ... , Dr. William Kutteh , director of Fertility ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014  Roche (SIX: ... of Bina Technologies, Inc. (Bina), a privately held ... , USA. Bina provides a big data ... generation sequencing (NGS) data. Bina,s proprietary on-market Genomic ... and academic researchers to perform fast and scalable ...
Breaking Biology Technology:Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... Equity, LLC issues a review of,VioQuest Pharmaceuticals, ... Submitted for Xyfid(TM) and Priority Review Voucher ... This review is available at website: ... a New Jersey-based biotechnology company,dedicated to becoming ...
... LA JOLLA, Calif., July 29 Zenobia ... received a Therapeutics Development,Initiative award from The ... program targets industry-based research with potential to,fundamentally ... treatment. In,collaboration with Dr. Christopher Ross of ...
... 29 ArunA Biomedical, Inc., the first,company to ... announced today that William T. Sharp has been ... his ArunA leadership,responsibilities, Mr. Sharp has also been ... ArunA founder Steven Stice, PhD, who will,remain ArunA,s ...
Cached Biology Technology:VioQuest Pharmaceuticals, Inc Valuation Upgrade Review Issued By Scimitar Equity, LLC 2Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinson's Research Award for Work on PD-implicated Protein LRRK2 2ArunA Biomedical Names William T. Sharp President and Chief Executive Officer 2
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
... The Microarray Gene Frame® has been ... These frames feature the same dual ... Gene Frame® range for easy removal ... uniformity and there are three sizes ...
Improves spot morphology and DNA binding to the slide resulting in increased hybridization signal. ID Clarifier: Optimized spotting solution for use with SigmaScreen APS Coated Slides for Microarrays...
... enables fully automated hybridization of microarrays on ... been designed to offer researchers improved reproducibility, ... perform a wide range of applications. ... 485C; denaturations of up to 99C. The ...
Biology Products: