Navigation Links
Chemists develop reversible method of tagging proteins
Date:9/16/2012

ental biochemical pathways that we still don't fully understand," he said. "We're now learning how these basic biosynthetic enzymes work. A large majority of drugs are derived from natural products and many future medicines can result from these pathways. There's a great interest now in synthetic biology, using these pathways to make new antibiotics or new anti-cancer drugs. They're all regulated by these same types of interactions."

The UC San Diego chemists say their method of tagging and removing chemical probes from proteins should also have wide application as a general laboratory tool to visualize and track proteins on living cells, as well as manipulate them outside of the cell.

"One could attach a tag, such as biotin, that would allow the protein to be purified. Then one can clip off the tag and attach a fluorescent molecule to monitor protein interaction with other molecular partners," said Burkart. "The method could also be used for studying living cells, such as observing protein expression levels throughout the cellular life cycle. We certainly see that as a possible application."

"Dr. Burkart's new labeling technique gives scientists an unprecedented way to probe the complex catalytic machineries involved in the biosynthesis of natural products," said Barbara Gerratana of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the work. "The technology will help scientists harness these natural biochemical pathways to synthesize novel molecules for uses in a broad array of areas, including basic biomedical research and drug discovery."


'/>"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Chemists advance clear conductive thin films
2. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
3. UC Berkeley chemists installing first carbon dioxide sensor network in Oakland
4. 23andMe opens its API to developers
5. Researchers develop rapid method to measure carbon footprints
6. IU chemist develops new synthesis of most useful, yet expensive, antimalarial drug
7. Humanized mice developed at OHSU enable malaria research breakthrough at Seattle BioMed
8. Students create low-cost biosensor to detect contaminated water in developing nations
9. Bacteria on marine sponges can develop capacity to move and inhibit biofilm formation
10. Realizing the promise of RNA nanotechnology for new drug development
11. New neural pathway controlling skeletal development discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... available in German . ... most common inherited disease affecting the peripheral nervous system. ... Planck Institute of Experimental Medicine and University Medical Centre ... is impaired in rats with the disease. These cells ... as myelin, which facilitates the rapid transfer of electrical ...
(Date:8/27/2014)... that a deficiency in serotonin a chemical messenger ... depression. In the journal ACS Chemical Neuroscience , ... serotonin in their brains (and thus should have been ... , Donald Kuhn and colleagues at the John ... School of Medicine note that depression poses a major ...
(Date:8/27/2014)... advocates, campaigns against trans-fats have largely succeeded in ... aim at sugar for its potential contributions to ... still wrangling over the best way to assuage ... article in Chemical & Engineering News ... Chemical Society. , In the article, Stephen Ritter, ...
Breaking Biology News(10 mins):Potential therapy for incurable Charcot-Marie-Tooth disease 2New study throws into question long-held belief about depression 2
... female hormone estrogen is known to offer protection for the heart, ... New research from the University of California at Merced finds that ... a greater impact on girls, blood pressure than it does on ... between 13 and 17 years old, obese boys were 3.5 times ...
... reached epidemic levels, and pediatricians are on the front ... pre-conference session at 11:30 a.m. Friday, Oct. 14, before ... Exhibition in Boston. The Pediatrics for the ... Innovations in Practice," challenges pediatricians to "step it up ...
... Oct. 11, 2011 Based on its recent analysis ... with the 2011 North American Frost & Sullivan Award ... Biometric Platform™ , - the first scalable, multi-modal biometrics ... iris recognition from a single server. To ...
Cached Biology News:Gender differences in blood pressure appears as early as adolescence 2Pediatricians aim to end childhood obesity within a generation 2Frost & Sullivan Recognizes M2SYS for its Path-Breaking Hybrid Biometric Platform(TM) That Offers Unparalleled Flexibility to End-Users 2Frost & Sullivan Recognizes M2SYS for its Path-Breaking Hybrid Biometric Platform(TM) That Offers Unparalleled Flexibility to End-Users 3Frost & Sullivan Recognizes M2SYS for its Path-Breaking Hybrid Biometric Platform(TM) That Offers Unparalleled Flexibility to End-Users 4
(Date:8/27/2014)... survive impact by the huge amounts of energy ... energy for photosynthesis. The hypothesis is that the ... the energy throughout the entire protein molecule through ... now managed to successfully ,film, this process. , ... which play a role in photosynthesis and thus ...
(Date:8/27/2014)... 27, 2014 Research and Markets ... Lactic Acid  (Biodegradable Polymer, Food & Beverage, Personal ... to 2019" report to their offering. ... with an asymmetrical carbon atom. The main applications ... food and beverage, personal care product, and pharmaceutical ...
(Date:8/27/2014)... 2014 “We are honored to be ... Ven Thangaraj, CEO of Radiant Sage. “We are offering ... the imaging corelab market to a different level. ... organizations to efficiently and effectively manage the massive amounts ... be analyzed and read by trained physicians. Being recognized ...
(Date:8/27/2014)... 2014 Flagship Biosciences LLC, a leading ... the pharmaceutical and medical device industries, has announced a ... growing company has consolidated its histology and tissue analysis ... Westminster, CO, just north of Denver. The new ... 103rd Ave., Suite 100, Westminster, CO 80021 , Tissue ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Flagship Biosciences Announces Relocation and Expansion 2
... (Nasdaq: NPSP ) today reported its financial results ... update on its 2007 milestones and,financial guidance. Update ... partnership with Nycomed to develop,GATTEX(TM) (teduglutide) outside North America, ... corporate milestones for 2007. The company announced that it,has: ...
... Merge Healthcare (Nasdaq: MRGE ; TSX: MRG), today,announced ... NASDAQ,Listing Qualifications Panel stating that the panel determined to ... NASDAQ Stock Market,subject to the Company,s filing of its ... no later than January 29, 2008. As indicated in ...
... Mass., Nov. 1 Proteon Therapeutics,( http://www.proteontherapeutics.com ... first-in-class pharmaceuticals to address the,medical needs of ... presenting,tomorrow at the Annual Meeting of the ... Human Elastase (PRT-201) Dilates Outflow,Veins in a ...
Cached Biology Technology:NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 2NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 3NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 4NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 5NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 6NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 7NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 8NPS Pharmaceuticals Reports Third Quarter 2007 Financial Results, Revises Financial Guidance 9NASDAQ Panel Grants Merge Technologies Additional Time to Regain Compliance 2NASDAQ Panel Grants Merge Technologies Additional Time to Regain Compliance 3Proteon Therapeutics to Present at Annual Meeting of American Society of Nephrology in San Francisco on November 2, 2007 2
... Software enables you to identify over ... can distinguish protein isoforms, protein subsets, ... also visualize peptide-protein associations and relationships ... protein identification and relative protein expression ...
... microscopes offer all of the features of ... Equipped with Koehler illumination, a centerable condenser ... B3 is the workhorse of Motic's range ... the need for re-focusing following a change ...
... Green II RNA gel stain is ... has bright fluorescence when bound to RNA ... ideal for use with either formaldehyde/agarose or ... UV transilluminators. A 500 µL unit size ...
... SYBR Green II RNA gel stain is ... bright fluorescence when bound to RNA and low ... with either formaldehyde/agarose or polyacrylamide gels using laser ... 100 minigels. A 500 µL unit size (S-7564) ...
Biology Products: