Navigation Links
Chemists design molecules for controlling bacterial behavior
Date:5/13/2014

Chemists in the College of Arts and Sciences have figured out how to control multiple bacterial behaviorspotentially good news for the treatment of infectious diseases and other bacteria-associated issues, without causing drug resistance.

Yan-Yeung Luk, associate professor of chemistry, has spearheaded the discovery, in conjunction with his research lab at Syracuse University and the Wang Lab at SUNY Upstate Medical University. Their findings are the subject of a forthcoming article in the journal ChemBioChem (John Wiley & Sons Inc.).

"Since the discovery of the first antibiotic, penicillin, in 1928, bacteria have become smarter and have developed resistance to many drugs," says Luk, an expert in bio-organic chemistry, nanomaterials and chemical biology. "They've done this by altering their genetic make-up; transferring drug-resistant genes between one another; and creating biofilms, which are multicellular communities where bacteria can be a thousand-fold more resistant to antibiotics."

In response, Luk's team has developed a class of chemical agents that does not kill bacteria but, rather, changes their multicellular behaviors. These agents are called disaccharide derivatives, and they mimic a class of natural molecules known as rhamnolipids, which are produced and secreted by the bacterium itself.

Luk says that while non-microbicidal (i.e., "non-killing") molecules are nothing new, his are unique because they target a new, yet-to-be-explained set of biological receptors.

"Rhamnolipids modulate at least three multicellular bioactivities in Pseudomonas aeruginosa," says Luk, referring to the rod-shaped bacterium that causes disease in animals and humans. "The synthetic molecules made by our lab don't exactly look like rhamnolipids, but they can control bioactivities, such as swarming movements, surface adhesion and biofilm formation."

This class, he adds, is non-microbicidal with a wide variety of microbes, thus giving it broad commercial value. It also has the potential to inhibit horizontal gene transferthe process by which bacteria share genetic information, such as the ability to be drug-resistant.

In the near future, Luk's team plans to unveil another class of molecules they have designed that not only mimics but also dominates the activities of rhamnolipids.

"Rhamnolipids are already on the market, but our product, with its synthetic flexibility, has just as many applications and may be improved rationally by synthetic design," says Luk, who also holds courtesy appointments in the Department of Biology in the College of Arts and Sciences and in the Department of Biomedical and Chemical Engineering in the College of Engineering and Computer Science. "All of this is subject to ongoing research."


'/>"/>

Contact: Rob Enslin
rmenslin@syr.edu
315-443-3403
Syracuse University
Source:Eurekalert  

Related biology news :

1. Inspired by moth eyeballs, UC Irvine chemists develop gold coating that dims glare
2. Chemists work with small peptide chains may revolutionize study of enzymes and diseases
3. Notre Dame chemists discover new class of antibiotics
4. Mentoring the next generation of black chemists (video)
5. CCNY chemists use sugar-based gelators to solidify vegetable oils
6. Biochemists find incomplete protein digestion is a useful thing for some bacteria
7. CCNY chemists devise new way to prepare molecules for drug testing
8. Biochemists uphold law of physics
9. University of Wisconsin chemists find new compounds to curb staph infection
10. UCI chemists devise inexpensive, accurate way to detect prostate cancer
11. Chemists devise inexpensive, benchtop method for marking and selecting cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemists design molecules for controlling bacterial behavior
(Date:2/2/2017)... TOKYO , Feb. 1, 2017  Central ... innovative and meaningful advances worldwide, The Japan Prize ... Japan Prize, who have pushed the envelope in ... Information and Communication. Three scientists are being recognized ... outstanding achievements that not only contribute to the ...
(Date:1/30/2017)... Jan. 30, 2017   Invitae Corporation (NYSE: ... genetic information companies, today announced that it will report ... provide 2017 guidance on Monday, February 13, 2017, and ... day at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... will briefly review financial results, guidance, and recent developments ...
(Date:1/25/2017)... , Jan. 25, 2017 The Elements ... Management (IAM) lifecycle is comprised of a comprehensive ... the purpose of maintaining digital identities and providing ... and applications. There are significant number of programs ... time to time by optimizing processes and changing ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... -- This Report analyzes the worldwide markets for Bioinformatics in US$ by ... comprehensive analytics for the US, Canada , ... Asia-Pacific , Latin America , and Rest ... ... estimates and forecasts are provided for the period 2015 through 2022. ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... Accredited venture-backed teleradiology and telemedicine company announces at HIMSS 2017 Annual Conference ... planned to be offered via a global cloud-based sharing and collaboration platform ...
(Date:2/20/2017)...  At the 2017 Health Information Management Systems ... , IBM (NYSE: IBM ) today introduced ... President and CEO Ginni Rometty will ... 8:30-10 am ET, broadcast live on www.ibm.com ... examine the advent of the Cognitive Era and ...
(Date:2/18/2017)... ... February 17, 2017 , ... The BMT Tandem Meetings of ... International Blood & Marrow Transplant Research (CIBMTR) will take place Feb. 22-26, 2017 ... combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical research professionals, nurses, pharmacists, ...
Breaking Biology Technology: