Navigation Links
Chemist receives NIH funding to unravel tricks of neuronal wiring
Date:12/29/2008

Joshua Maurer, Ph.D., assistant professor of chemistry in Arts & Sciences, has received a four-year, $1,216,000 grant from the National Institute of Mental Health for research titled "Unraveling Development: New Materials for Understanding Neuronal Wiring."

Maurer's long term objective is to develop methodology that allows the study of a variety of neuronal wiring processes. He is starting by unscrambling a phenomenon known as midline crossing using zebrafish. During development, neurons from the right eye cross the midline of the brain to make a connection in the left hemisphere.

"Our goal is to build a substrate that looks like what a growing neuron would encounter in the brain as it goes from the eye to where it has to make its final connection in order to do a feedback response," Maurer explained. "We want to replicate the interactions (in the brain) on a glass surface by laying down a series of molecules with nanoscopic control. Then we can watch in real time, with a microscope, how a neuron is guided through this pattern."

Their findings could help explain more about the fundamentals of nerve damage and enable better nerve repair some day.

They are developing strategies that give "robust, stable" surfaces that can be studied for weeks. Current techniques give surfaces with limited stability, around 5 days. "We have recently published new patterning techniques that allow us to build protein patterns directly on glass and are just starting to meet our goals of building complex systems," Maurer said.

Traditionally, to elucidate a protein's role in a known pathway, scientists make a "knockout" animal by inactivating the gene that codes for the protein and observing the resulting effect in the animal. However, this technique cannot be used to study proteins involved in development because these proteins can have multiple functions.

"If you knock out a developmental protein, there is a potential that
'/>"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clemson chemists discover new way antioxidants fight debilitating diseases
2. Computational actinide chemistry: Are we there yet?
3. Chemists get grip on slippery lipids
4. American Chemical Society calls green chemistry bill a smart step
5. Using green chemistry to deliver cutting-edge drugs
6. Good earth: Brown chemists show origin of soil-scented geosmin
7. Penn biochemist receives NIH New Innovators Award
8. Chemistry turns killer gas into potential cure
9. K-State chemistry professor to receive Masao Horiba award
10. Yale chemist receives NIH Young Investigator Award for antibody targeting
11. Biogeochemistry -- A window into the Earths ecological health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... to play a major role in the studies ... a life-threatening parasitic disease that kills nearly one ... advanced our understanding of malaria, new models are ... Institute for Mathematical and Biological Synthesis (NIMBioS) is ...
... 18, 2011 -- Physicists and bioengineers have developed an ... a worm just by shining a tightly focused beam ... The pioneering optogenetic research, by a team at Harvard ... Massachusetts Medical School, is described this week in the ...
... the first view of DNA damage throughout the entire ... a valuable new insight into the development and treatment ... Dr Simon Reed and Dr Yumin Teng from Cardiff ... a unique way of measuring DNA damage frequency using ...
Cached Biology News:Malaria modeling and control focus of workshop 2Sharply focused on neurons, light controls a worm's behavior 2New technology provides first view of DNA damage within entire human genome 2
(Date:5/20/2015)... , May 20, 2015  Marc Tessier-Lavigne, president ... gift of $100 million from The Marie-Josée and ... new laboratory building that will be the centerpiece ... Marie-Josée and Henry R. Kravis Research Building, two ... Drive, spanning approximately three city blocks following the ...
(Date:5/20/2015)... May 20, 2015  Cypher Genomics, Inc., a ... with Celgene Corporation to apply Cypher,s Coral TM ... associate with patient response to innovative medicines. The ... help accelerate patient access to the right medicine ... research and development and potentially inform new companion ...
(Date:5/20/2015)... 19, 2015 Research and Markets ... the "Bone Morphogenetic Proteins Market (Types : ... and Oral - Maxillofacial) - Global Industry Analysis, ... 2022" report to their offering. ... based on the types of recombinant BMPs, applications, ...
(Date:5/20/2015)... (PRWEB) May 20, 2015 Optivia ... assay services for Drug-Drug Interactions (DDI), Metabolism and ... a world leader in assessing impact of drugs ... Pharmacology supported by biosimulation, announced today that they ... allows both companies to expand their product and ...
Breaking Biology Technology:The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Global Bone Morphogenetic Proteins Market Industry Analysis 2014 - 2022 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 3
... Louvain, Belgium Cancer is the major cause of ... predict that, by about 2010, cancer will be the ... VIB scientists connected to the Katholieke Universiteit Leuven, in ... studying the anti-cancer action of anti-PLGF. This substance appears ...
... Delft University of Technologys Kavli Institute of Nanoscience and ... succeeded in controlling the spin of a single electron ... for a much simpler realization of the building blocks ... publish their work in Science Express on Thursday 1 ...
... BioFuel Energy Corp. (Nasdaq:,BIOF) announced today that ... Wednesday, November 7, 2007, after the market closes. ... plans to host a conference call on Thursday, ... discuss the third quarter results. To,participate, please dial ...
Cached Biology Technology:On the road to a new cancer therapy -- starving the tumor 2On the road to a new cancer therapy -- starving the tumor 3Delft University of Technology rotates electron spin with electric field 2
...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... MasterAmp™ Taq DNA Polymerase is a ... aquaticus. Having optimal activity at temperatures ... thermostable enzyme used for PCR and ... purpose. The enzyme has an intrinsic ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
Biology Products: