Navigation Links
Chemist receives NIH funding to unravel tricks of neuronal wiring

Joshua Maurer, Ph.D., assistant professor of chemistry in Arts & Sciences, has received a four-year, $1,216,000 grant from the National Institute of Mental Health for research titled "Unraveling Development: New Materials for Understanding Neuronal Wiring."

Maurer's long term objective is to develop methodology that allows the study of a variety of neuronal wiring processes. He is starting by unscrambling a phenomenon known as midline crossing using zebrafish. During development, neurons from the right eye cross the midline of the brain to make a connection in the left hemisphere.

"Our goal is to build a substrate that looks like what a growing neuron would encounter in the brain as it goes from the eye to where it has to make its final connection in order to do a feedback response," Maurer explained. "We want to replicate the interactions (in the brain) on a glass surface by laying down a series of molecules with nanoscopic control. Then we can watch in real time, with a microscope, how a neuron is guided through this pattern."

Their findings could help explain more about the fundamentals of nerve damage and enable better nerve repair some day.

They are developing strategies that give "robust, stable" surfaces that can be studied for weeks. Current techniques give surfaces with limited stability, around 5 days. "We have recently published new patterning techniques that allow us to build protein patterns directly on glass and are just starting to meet our goals of building complex systems," Maurer said.

Traditionally, to elucidate a protein's role in a known pathway, scientists make a "knockout" animal by inactivating the gene that codes for the protein and observing the resulting effect in the animal. However, this technique cannot be used to study proteins involved in development because these proteins can have multiple functions.

"If you knock out a developmental protein, there is a potential that you affect some upstream event so you never do the event you are interested in," Maurer said.

Maurer's neuronal "road map" overcomes this problem by isolating the guidance system from the zebrafish's neurobiological milieu. By watching the neuron grow in real time, he will be able to determine exactly which proteins tell the neuron to turn left, right, or stop.

Knowledge gained in these studies could be applied to reconnecting severed nerves in humans. "This eye crossing event happens in every organism with two eyes. Last time I checked that was all of them. I don't see any cyclopses wandering around," Maurer said.


Contact: Tony Fitzpatrick
Washington University in St. Louis

Related biology news :

1. Clemson chemists discover new way antioxidants fight debilitating diseases
2. Computational actinide chemistry: Are we there yet?
3. Chemists get grip on slippery lipids
4. American Chemical Society calls green chemistry bill a smart step
5. Using green chemistry to deliver cutting-edge drugs
6. Good earth: Brown chemists show origin of soil-scented geosmin
7. Penn biochemist receives NIH New Innovators Award
8. Chemistry turns killer gas into potential cure
9. K-State chemistry professor to receive Masao Horiba award
10. Yale chemist receives NIH Young Investigator Award for antibody targeting
11. Biogeochemistry -- A window into the Earths ecological health
Post Your Comments:
(Date:10/29/2015)... 2015 NXTD ) ("NXT-ID" ... on the growing mobile commerce market and creator ... a leading marketplace to discover and buy innovative ... wallet on StackSocial for this holiday season.   ... "Company"), a biometric authentication company focused on the ...
(Date:10/27/2015)... -- In the present market scenario, security is one ... verticals such as banking, healthcare, defense, electronic gadgets, and ... secure & simplified access control and growing rate of ... bank accounts, misuse of users, , and so on. ... and smartphones are expected to provide potential opportunities for ...
(Date:10/27/2015)... Oct. 27, 2015 Synaptics Inc. (NASDAQ: SYNA ... that Google has adopted the Synaptics ® ClearPad ... to power its newest flagship smartphones, the Nexus 5X ... --> --> Synaptics ... provide strategic collaboration in the joint development of next ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... 01, 2015 , ... Matthew “Tex” VerMilyea, PhD, HCLD, has joined Texas Fertility ... all IVF lab procedures as well as continue his research efforts into the emerging ... to Auckland, New Zealand to bring home a High Complexity Clinical Laboratory Director named ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... Manufacturing Practice (GMP) 10000 in the Santiago Marriott. The Global Stem Cells Group ... by a world-class team of qualified medical researchers and practitioners, experienced in administering ...
(Date:11/30/2015)... , December 1, 2015 Partnership includes ... for the u niversity , ... support treatment s cale - up ... (ARVs)   Africa , where licensees based anywhere in ... based on SDN technology. --> Africa , where licensees based ...
(Date:11/30/2015)... BETHESDA, Md. , Nov. 30, 2015 /PRNewswire/ ... property development company committed to the fostering and ... on the current and prospective initiatives designed to ... , Chief Executive Officer of Spherix. "Based on ... potential future licensees exceeds $50 billion and Spherix ...
Breaking Biology Technology: