Navigation Links
Chemical in blood may explain susceptibility to bladder pain
Date:6/15/2009

oscopy identifies the biochemical content of a blood sample based on where peaks of molecules appear in the infrared spectrum. Samples from humans and cats with interstitial cystitis demonstrated nearly identical molecular peaks.

"It's a powerful enough technique that we might even be able to identify subtle differences in patients with multiple diseases that exist in addition to, but that are unrelated to, the interstitial cystitis," he said.

The researchers then determined the chemical structures within those molecular profiles, which showed that blood from cats with the syndrome contained at least 20 percent more tryptophan and kynurenine than did samples from healthy cats. Kynurenine is a brain compound produced when tryptophan breaks down in the body. An elevated level of kynurenine suggests that tryptophan is being diverted from its conversion into a chemical responsible for sending signals in the brain.

This testing method differentiated between diseases in humans as well, classifying the samples as coming from either healthy subjects, IC patients, or patients with another urological disorder, Buffington said.

In addition to improving the potential to diagnose interstitial cystitis, understanding chemical processes related to this chronic disease could offer new directions for the pursuit of treatments and even prevention strategies, he said.

"It's all speculative, but it may be that there is some kind of primary central nervous system disorder that results in problems in the bladder in some people, and in the gut or other organs in others," Buffington said. "It is possible that this is a biomarker for the underlying vulnerability or susceptibility."

Buffington has led studies that show that in cats, feline interstitial cystitis can be managed through a series of changes to the affected animals' environment that reduce stressors and promote stability and predictability.

"We can put these cats into
'/>"/>

Contact: Tony Buffington
buffington.1@osu.edu
614-292-7987
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
3. Thermochemical process converts poultry litter into bio-oil
4. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
5. Natural chemical found in broccoli helps combat skin blistering disease
6. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
7. American Chemical Societys Weekly Press Pac
8. Amber specimen captures ancient chemical battle
9. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
10. American Chemical Society calls green chemistry bill a smart step
11. Institution of Chemical Engineers chooses Elsevier as publishing partner
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... – Bacteria in the gastrointestinal tract fulfill many ... these same bacteria can induce strong inflammatory responses ... gut and enter the bloodstream. , Although acute ... body, chronic or systemic inflammation is linked to ... the involvement of inflammatory processes in the development ...
(Date:10/30/2014)... 2014  Securus Technologies, a leading provider ... for public safety, investigation, corrections and monitoring, ... enhancements to its THREADS™ product, which utilizes ... intelligence and focused leads for investigators. ... innovation through identifying and delivering solutions serving ...
(Date:10/29/2014)... its kind to date, researchers have used DNA sequencing ... for autism. Joseph Buxbaum, Ph.D., Icahn School of Medicine ... Broad Institute of Harvard and MIT, and their colleagues ... parents and unrelated people. They identified changes in 107 ... for autism spectrum disorder (ASD) – a jump from ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2
... Institute for Research in Immunology and Cancer (IRIC) at ... quantity of laboratory stem cells from a small number ... multidisciplinary team, directed by Dr. Guy Sauvageau, thus took ... treatment based on these stem cells. This worldwide first ...
... kind study examining the effects of methamphetamine use during pregnancy ... in children. The research is published in the April 15, ... of the American Academy of Neurology. "Methamphetamine ... leading to an increasing number of children with prenatal meth ...
... In acute ischemic stroke, the blood supply to the ... of oxygen. In addition, ischemia activates harmful inflammatory processes ... first time, scientists at the Neurology Clinic at Heidelberg ... the blood inhibit inflammation after a stroke. These cells ...
Cached Biology News:World premiere in stem cell research in Montreal 2Prenatal meth exposure linked to abnormal brain development 2'First aid' for brain cells comes from blood 2
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... SoundConnect , an industry leading ... end users the key to turning this already ... adding voice enablement and hybrid audio conferencing. , ... communication tool that includes presence, instant messaging and ... becomes a comprehensive unified communications solution. Adding the ...
(Date:10/30/2014)... 2014 James Sherley says he has been ... stem cell technology since his days as a principal investigator ... the late 1990’s. Sherley founded the ASCTC as a ... all the intellectual property developed in Sherley’s research over the ... Institute of Technology (MIT), and more recently as a senior ...
(Date:10/30/2014)... October 30, 2014 Whitehouse Laboratories has ... ICH Stability Testing and Package Test Capacity. Responding to ... on a dramatic increase in environmental chamber storage space ... storage and aging samples to be securely held on ... major capital expenditure has already taken place with the ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3
... Wis. - Building efficiency and power solutions giant ... of its executive positions reflecting the creation an Executive ... president, was named chairman of the EOC, a committee ... since 1982, Roell served as vice president and chief ...
... at a Pennsylvania teaching and research hospital are integrating ... to distribute information about diabetes, cancer, heart disease, and ... S. Hershey Medical Center recently purchased the Web-based ... forums, and internal staff meetings to medical students and ...
... is a concept that appears a long way from ... genetic-based medicine is closer than we think. , ,In ... identify the patient's predisposition to various diseases, and to ... environmental characteristics. , , Stephens Cracking ...
Cached Biology Technology:Medical College researcher working to make genetic-based medicine a reality 2Medical College researcher working to make genetic-based medicine a reality 3
... Facility , Galaxy LIMS, Sophisticated Bioinformatics , ... scientists ,We offer individual sample sequencing of ... for single or double strand publication quality. ... DNA of interest is 1.3 to 7 ...
... sequencing of individual research samples, including PCR ... Agencourt's world-class, high performance sequencing pipeline processes ... The key benefits of Agencourt's QuickLane ... 48 hour sample turnaround, industry leading sequence ...
Shotgun library construction and high-throughput DNA sequencing of microbial genomes, BACs, adenoviruses, phosmids and cosmids. LIMS tracking utilizing Geospiza's Finch system....
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
Biology Products: