Navigation Links
Chemical engineers help decipher mystery of neurofibrillary tangle formation in Alzheimer's brains
Date:11/1/2011

Neurofibrillary tangles odd, twisted clumps of protein found within nerve cells are a pathological hallmark of Alzheimer's disease. The tangles, which were first identified in the early 1900s by German psychiatrist and neuropathologist Aloysius Alzheimer, are formed when changes in a protein called tau cause it to aggregate in an insoluble mass in the cytoplasm of cells. Normally, the tau protein is involved in the formation of microtubules, hollow filaments that provide cells with support and structure; abnormal tau tangles, however, cause that structure to break down, and lead to cell death.

Researchers have long puzzled over just what produces the tangles and, indeed, if they are a cause or a side effect of Alzheimer's and similar neurodegenerative diseases. Now, new research by Eva Chi, an assistant professor of chemical engineering at the University of New Mexico, and her colleagues suggests that changes to the lipid membranes of nerve cells initiate tangle formation.

"Proteins in the brain do not aggregate spontaneously to form amyloid fibrils to cause diseases," says Chi. Rather, she says, "there are physiological triggers that cause these proteins to start aggregating and the lipid membrane may serve such a role." At the AVS Symposium in Nashville, Tenn., held Oct. 30 Nov. 4, Chi will discuss these tangling triggers and their implications for the development of new Alzheimer's therapies.

Using a combination of techniques, including fluorescence microscopy and X-ray and neutron scattering imaging, Chi and her colleagues found that tau proteins inside nerve cells interact strongly with negatively charged lipids, which are found on the inner surface of cell membranes. "In diseased brains, tau proteins become hyperphosphorylated" adorned with multiple phosphate (PO43-) groups "and detach from microtubules. They can then interact with the negatively charged lipids on the cell membrane and start to aggregate into fibrils and
'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Exposure to chemical BPA before birth linked to behavioral, emotional difficulties in girls
2. Colossal aggregations of giant alien freshwater fish as a potential biogeochemical hotspot
3. Tobin Marks awarded Dreyfus Prize in the Chemical Sciences
4. Catalyst discovery has potential to revolutionize chemical industry
5. New method cleans up textile industrys most dangerous chemicals
6. FASEB announces new client: The Histochemical Society
7. Biochemical cell signals quantified for first time
8. Rutgers, UMDNJ receive $23 million to develop antidotes for chemical weapons attacks
9. Scented laundry products emit hazardous chemicals through dryer vents
10. Scientists find easier, cheaper way to make a sought-after chemical modification to drugs
11. News media registration for American Chemical Society National Meeting Denver, Aug. 28-Sept. 1, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
(Date:3/24/2015)... NexID Biometrics LLC, whose spoof-mitigation technology boosts protection ... beginning of shipments of version 2.0 of its industry ... in Potsdam, N.Y. , is making ... here today at the Walter E. Washington Convention Center. ... boosts the accuracy rate range to 96.5 to 99.5 ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... Bethesda, MD FASEB MARC (Minority Access to Research ... The American Society for Bone & Mineral Research (ASBMR) ... 15-19, 2010. These awards are meant to promote ... into the mainstream of the basic science community and ...
... of infants each year have exposure to opioids before ... born with withdrawal symptoms severe enough to require opioid ... with long hospital stays which interferes with maternal/infant bonding. ... has tested a semi-synthetic opioid they say has the ...
... Biochemistry and Scripps Institution of Oceanography at UC San ... about how chemistry influences climate and atmospheric processes. ... Center for Aerosol Impacts on Climate and the Environment ... of aerosol particles and the chemical reactions occurring at ...
Cached Biology News:Drug that helps adults addicted to opioid drugs also relieves withdrawal symptoms in newborns 2Scripps researchers, UCSD chemists to create center devoted to chemistry's influence on climate 2Scripps researchers, UCSD chemists to create center devoted to chemistry's influence on climate 3
(Date:4/16/2015)...  EMD Serono today announced the US biopharmaceutical ... , appointed Alise Reicin , MD, ... Development.  Dr. Reicin brings extensive research and early/late ... Immunology. She is an accomplished pharmaceutical executive with ... President in various capacities across R&D at MSD ...
(Date:4/16/2015)... and MENLO PARK, Calif. ... (OTCQX: DMPI) (DelMar and the Company), a biopharmaceutical ... in new orphan drug indications, today announced that the ... as a clinical trial site for the ongoing, multicenter ... glioblastoma multiforme (GBM), the most common and deadly form ...
(Date:4/16/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ... DCVax® personalized immune therapies for cancer, announced today ... Cancer Immunotherapy Index (LCINDX), a professional index recently ... field within the biotechnology space.  ... companies" in the immunotherapy space, including 6 big ...
(Date:4/16/2015)... Modality Solutions, a company that delivers ... industries, is pleased to announce its President, Gary ... Cold Chain IQ - Temperature Control Logistics and ... Global Cold Chain Connections, is dedicated to sharing ... pharmaceutical and healthcare supply chains. , Cold ...
Breaking Biology Technology:Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 2DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 4DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 5NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 2Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 3
... a new nanomaterial that can "steer" electrical currents. The ... reconfigure its internal wiring and become an entirely different ... are built smaller and smaller, the materials from which ... and begin to be controlled by quantum mechanical phenomena. ...
... ultra-thin sheets of carbon, just one atom thick, whose ... Physics. The seemingly simple material is graphene, ... applications, from electronic devices to high-performance composite materials. ... internal structure at all, it offers an abundance of surface ...
... Blood Corporation (NYSE: CO ) ("CCBC" or "the ... today announced that the Company will hold its annual general meeting ... China Tower, 1 Garden Road, Central, Hong Kong, at 9:00 p.m. ... Time on December 19, 2011).   Shareholders of record ...
Cached Biology Technology:Could a computer one day rewire itself? 2Frustration inspires new form of graphene 2China Cord Blood Corporation to Hold Annual General Meeting in Hong Kong on December 19, 2011 2
... Nonanoyl-N-methylglucamide ... properties. Can be readily removed by ... Purity: ≥98% by HPLC. ... nm): 2 O. CMC 19 ...
...
...
... Tecans MiniPrep series of robotic workstations ... The MiniPrep is the ideal automation ... automation of routine laboratory procedures, improving throughput, ... based Gemini for MiniPrep software allows you ...
Biology Products: