Navigation Links
Chemical engineers at UCSB design molecular probe to study disease
Date:4/6/2011

(Santa Barbara, Calif.) Chemical engineers at UC Santa Barbara expect that their new process to create molecular probes may eventually result in the development of new drugs to treat cancer and other illnesses.

Their work, reported in the journal Chemistry & Biology, published by Cell Press, describes a new strategy to build molecular probes to visualize, measure, and learn about the activities of enzymes, called proteases, on the surface of cancer cells.

Patrick Daugherty, senior author and professor of chemical engineering at UCSB, explained that the probes are effective at understanding proteases involved in tumor metastasis.

"Tumor metastasis is widely regarded as the cause of death for cancer patients," said Daugherty. "It's not usually the primary tumor that causes death. Metastasis is mediated by proteases, like the one we are studying here. These proteases can enable tumor cells to separate and degrade surrounding tissue, and then migrate to sites distant from the primary tumor. The tumor doesn't just fall apart. There are many events that must occur for a tumor to release cancerous cells into the blood stream that can circulate and end up in other tissues such as liver or bone."

The probes allowed the researchers, for the first time, to measure directly the activity of a protease involved in metastasis. They did this by adding their probe into a dish of tumor cells. They then measured the activity of this protease that breaks down collagen the single most abundant protein (by mass) in the human body.

"We have immediate plans to use similar probes to effectively distinguish metastatic HER2 positive tumors, one of the most commonly used biomarkers of breast cancer," said Daugherty. "A significant fraction of patients have HER2 positive tumors but we don't know which of those tumors is going to metastasize yet. But our ability to make these probes can allow us to identify which of those HER2 positive
'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Chemical equator discovery will aid pollution mapping
2. Researcher working on destruction of chemical weapons
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. American Chemical Societys Weekly PressPac -- Sept. 24, 2008
5. A major prize in the chemical sciences announced by the Camille and Henry Dreyfus Foundation
6. American Chemical Societys Weekly PressPac
7. American Chemical Society Weekly PressPac Oct. 15, 2008
8. UC Davis chemical ecologist wins major award
9. Sniffing out a better chemical sensor
10. Simple chemical procedure augments therapeutic potential of stem cells
11. Researchers use chemical from medicinal plants to fight HIV
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemical engineers at UCSB design molecular probe to study disease 
(Date:6/17/2015)... HILDEN, Germany , June 17, 2015 /PRNewswire/ ... Prime Standard: QIA) today launched new Investigator ® STR ... in the United States . The new ... multiple key genomic markers (short tandem repeats or STRs) for ... to evaluate the quality of DNA in each sample, a ...
(Date:6/17/2015)... PALM BEACH GARDENS, Fla. , June 17, ... identity management solutions, today announced that its U.are.U ... by Togo,s Eateries, Inc., ... based fast casual sandwich chain, to increase security, ... (POS). The Crossmatch fingerprint readers enable instant, non-repudiable identity ...
(Date:6/16/2015)... YORK , June 16, 2015  With the ... world, security remains a top concern. The recent compromise ... confirms the need for strong authentication within government agencies. ... Token, a biometric one-time password (OTP) authenticator, has been ... Standards (FIPS) 140-2 Level 3 validation for tamper proofing. ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... Jewish Health and four other research centers have been ... Heart Lung and Blood Institute as part of the ... national scientists to delve deeply into the biology of ... therapeutic options. The multi-center Lung Genomics Research Consortium will ...
... CITY, Calif., Oct. 7 DigitalPersona, Inc., a ... announced that Panasonic System Solutions Company is now ... field-upgradeable option on Panasonic,s modular point-of-sale (POS) workstation, ... a modular case that can be attached to ...
... degradation in dryland regions continuing to worsen, the ... scientist-recommended indicators for monitoring and assessing desertification that ... agreement was reached after two weeks of negotiations ... the Ninth Session of the Conference of the ...
Cached Biology News:NHLBI awards $11 million for molecular roadmap to chronic lung diseases 2Panasonic Offers U.are.U(R) Fingerprint Sensor From DigitalPersona on Stingray JS-950 Point-of-Sale Workstations 2Satellite data instrumental in combating desertification 2Satellite data instrumental in combating desertification 3
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... ... CentrePoint Study Admin system was developed to solve many of the ... analysis, particularly within studies that involve multiple clinical sites and/or remote data coordination ...
(Date:7/6/2015)... Calif. , July 6, 2015  Approximately 1% ... is integrated into their chromosomes. These individuals are three ... new study published in one of the nation,s leading ... of Medicine in Canada.  Photo - ... human herpesvirus 6 (HHV-6) causes roseola (also known as ...
(Date:7/6/2015)... 6, 2015 Navitas, a leading Regulatory Service provider, today announced ... hub in Bogota, Colombia . Navitas, expansion into ... provided by Colombia , the third largest economy in ... Logo - http://photos.prnewswire.com/prnh/20150703/228239LOGO ... based clients to communicate with Navitas regulatory professionals in close to or ...
(Date:7/3/2015)... , ... July 03, 2015 , ... ... by Fortune 500 companies and professional service industries alike-- typically known for its ... clients laugh, honor a good cause and break from their day jobs. , ...
Breaking Biology Technology:ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Navitas Launches Latin American Regulatory Operations Hub in Bogota, Colombia 2Navitas Launches Latin American Regulatory Operations Hub in Bogota, Colombia 3The Alexander Group Declares Their Independence with a Bit of Levity 2
... GENEVA , February 3 Viroblock SA, ... products, today,announced that Dr. Jamie Paterson will join Viroblock ... Paterson , a British national, can look back at 20 years ... Commercial Officer at Neurim Pharmaceuticals. During his 18 years at,Procter & ...
... This release is available in German . ... A white light appears out of nowhere. And a light ... upon close examination does the source of the apparently supernatural ... passes through thousands of infinitesimal lens structures measuring only a ...
... ... drug development community thanks to their complexity and substantial potential benefits for sponsors and patients. ... Inc. discusses the rapid evolution of the adaptive trial model and the latest thinking about ... ...
Cached Biology Technology:Viroblock SA Hires Dr. Jamie Paterson as CEO and Closes Financing Round 2Nano for the senses 2Nano for the senses 3Adaptive Trial Paper Explores Benefits of Adaptive Trials for Phase I, Phase II Studies 2Adaptive Trial Paper Explores Benefits of Adaptive Trials for Phase I, Phase II Studies 3Adaptive Trial Paper Explores Benefits of Adaptive Trials for Phase I, Phase II Studies 4
... Preparation contains a unique β-agarose digesting enzyme ... of intact DNA and RNA from low ... in TAE, TBE, MOPS, or phosphate buffers. ... the TAE, TBE, MOPS, and phosphate electrophoresis ...
Request Info...
... new Thermo Electron RapidStak provides valuable walk-away ... a unique buffer nest technology for parallel ... RapidStak provides fast, reliable automation for any ... walk-away confidence. The RapidStak can be set-up ...
... genetically engineered endonuclease. This unique enzyme degrades ... having no proteolytic activity. It is effective ... possesses an exceptionally high specific activity. Ideal ... proteins, its use enables compliance with FDA ...
Biology Products: