Navigation Links
Chemical competition: Research identifies new mechanism regulating embryonic development
Date:3/9/2010

ncluding the tail.

Using special techniques to visualize whether the proteins had interacted with the MAPK enzyme, the team found that the relative amount of the first protein controlled how much enzyme was available to interact with the second protein. For example, in the portion of the embryo that would become the head, where the concentration of the first protein was high, much less enzyme was available to act on the second protein than at the other end of the embryo, where the tail would ultimately develop.

"This competition makes sure that the same enzyme signals are interpreted differently in the head and in the tail, thereby allowing for the integration of multiple signals," Shvartsman said.

Based on how the enzyme interacted with the proteins in the head region of the embryo, the team predicted that a third protein also might be competing for the MAPK enzyme in that area. To test the hypothesis, research team members at the Institute for Medical Research Israel-Canada at Hebrew University in Jerusalem used a series of experimental techniques to verify that their proposed protein could bind to the enzyme, an ability that was previously unknown. These findings suggest that the competition model may provide a novel way to identify proteins that are involved in signaling pathways.

Beyond advancing the fundamental understanding of mechanisms that control embryonic patterning, the work has implications for how to target cancer cells, which often exhibit hyperactive MAPK signaling.

"According to our substrate competition idea, MAPK signaling activity directed toward any given substrate decreases when you introduce a competing substrate," Kim said. "In theory, you can lower the activity of MAPK if you introduce a protein whose sole function is to bind to MAPK and thus act as a competitive inhibitor of MAPK signaling to all other substrates." This strategy might one day allow scientists to slow or stop MAPK signaling
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
3. Thermochemical process converts poultry litter into bio-oil
4. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
5. Natural chemical found in broccoli helps combat skin blistering disease
6. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
7. American Chemical Societys Weekly Press Pac
8. Amber specimen captures ancient chemical battle
9. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
10. American Chemical Society calls green chemistry bill a smart step
11. Institution of Chemical Engineers chooses Elsevier as publishing partner
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chemical competition: Research identifies new mechanism regulating embryonic development
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... When a pathogen attacks a plant, infection usually follows ... of researchers at the University of California, Riverside focused on ... of the 19 th century by infecting potato plants, ... system. The genus Phytophthora contains many notorious ...
... As fibers go, there,s never been anything quite like spider silk. ... holds up. It is five times stronger than steel and can ... right back like new. Ounce-for-ounce spider silk is even stronger than ... be understandable to think that science knows all there is to ...
... needs to eat. But it,s a dog-eat-dog world, and with ... To cope with this vicious reality, a tiny insect that ... physical protection from its beetle predator. The pest ... numerous countries in recent years has caused immeasurable loss of ...
Cached Biology News:Scientists identify genetic mechanism that contributed to Irish Famine 2Scientists identify genetic mechanism that contributed to Irish Famine 3Stanford researcher sheds new light on the mysteries of spider silk 2Stanford researcher sheds new light on the mysteries of spider silk 3Stanford researcher sheds new light on the mysteries of spider silk 4Pest uses plant hairs for protection 2
(Date:5/28/2015)... , May 28, 2015 RXi Pharmaceuticals Corporation ... discovering and developing innovative therapeutics, primarily in the areas ... a public offering of 26 million units at a ... gross proceeds of approximately $10.4 million. Each unit consists ... 13-month overallotment purchase right to purchase 0.50 of a ...
(Date:5/28/2015)... 2015  GenVec, Inc. (Nasdaq: GNVC ) today ... Swirsky , will present a company overview at the ... on Thursday, June 4, 2015. The ... be available at the following link:  http://wsw.com/webcast/jeff88/gnvc .  ... To access, visit www.genvec.com , click on "Investors ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 The Fertility ... our own Dr. Danielle Vitiello has taken on a ... role, Dr. Vitiello will provide guidance, leadership, oversight and ... to count Dr. Vitiello among our team of experienced ... and CEO, Joseph A. Hill, M.D. “Her expertise and ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
Breaking Biology Technology:RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3
... and OTTAWA, Nov. 20 Sports and,nutritional product ... http://www.naturalnutritioninc.com announced today that it has,launched an ... Lightning Pain Relief Cream. Made from a combination ... be marketed,on the internet and television. Natural ...
... Spheris to be the First Provider of Clinical Documentation Technology, ... ... Tenn., Nov. 20 Spheris has been selected as,the first ... of the nation,s leading group purchasing organizations.,Under the parties, agreement, ...
... CRY ),a biomaterials, medical device and tissue processing company, ... 19th Annual Piper Jaffray,Health Care Conference at the Pierre ... Steven G. Anderson, president and CEO of CryoLife, ... p.m. EST. CryoLife,s live presentation may be accessed ...
Cached Biology Technology:Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief 2Provista Awards Agreement to Spheris 2CryoLife to Present at 19th Annual Piper Jaffray Health Care Conference in New York 2
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
5-bromouridine 5'-triphosphate (BrUTP) *10 mM in TE buffer*...
...
in vitro Translation, Accessory Products...
Biology Products: