Navigation Links
'Chemical architects' build materials with potential applications in drug delivery and gas storage
Date:6/17/2013

PITTSBURGHHome remodelers understand the concept of improving original foundations with more modern elements. Using this same approachbut with chemistryresearchers in the University of Pittsburgh's Kenneth P. Dietrich School of Arts and Sciences have designed a family of materials that could make drug delivery, gas storage, and gas transport more efficient and at a lower cost. The findings were reported in the latest issue of the Journal of the American Chemical Society (JACS).

The recent work builds upon Pitt Associate Professor of Chemistry Nathaniel Rosi's earlier research published last year in Nature Communications detailing a new class of metal-organic frameworkscrystalline compounds consisting of metal vertices and organic linkers that form porous structures. Last year, Rosi and his team created one of the most porous materials known at the time by changing the size of the vertex (the metal cluster) rather than the length of the organic linkers. Now, in JACS, he and his team have extended those linkers, demonstrating a family of materials even more porousa property necessary for more efficient gas storage.

"We like to think of ourselves as chemical architects," said Rosi, principal investigator of the project. "Our approach always starts with thinking about structure and, in particular, how we can design and manipulate structure. Here, we demonstrate one of the most porous families of metal-organic frameworks known."

Rosi likens his work to that of a builder remodeling a child's chair. As the child grows taller, the legs of the chair become too short. Because the owner likes the structure and integrity of the chair, the owner decides to lengthen its legs instead of purchasing a new one. This is what Rosi and his team have done with their frameworks: they have used one material as a structural blueprint and replaced another element (the organic linkers) to prepare more porous materials.

In addition to their utility for gas storage, these porous materials could be critical for low-cost industrial separationswhen one molecule is separated from another batch of molecules for purification purposes. The petrochemical industry has numerous high-value (and high-cost) separations used to isolate important chemicals involved with oil refining. Some of these separations could benefit from the use of porous materials as filters, said Rosi. Likewise, he notes that the pore size for his class of materials would be particularly useful for separating nanoparticles. Porosity also can affect the efficiency of pharmaceutical delivery into the human body.

An important metric for evaluating the porosity of a material is its pore volume. In Rosi's demonstration, three of these materials have pore volumes exceeding 4 cubic centimeters per gram (cc/g). For perspective, only one other metal-organic framework has a pore volume above this amount, with most others having volumes below 3 cc/g.

"Pore volume is a measure of how empty or vacant a material ishow much space in the material isn't filled," said Rosi. "When the pore openings are large, and the pore volume is large, it opens up the possibility of using the material as a scaffold to precisely organize and position biomolecules or nanoparticles in space."

Rosi and his team are currently investigating high-porous and low-density materials to be used as scaffolds for organizing large molecules and nanoparticles into functional materials.


'/>"/>

Contact: B. Rose Huber
rhuber@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

Related biology news :

1. American Chemical Societys highest honor goes to Stephen J. Lippard, Ph.D.
2. Medicine, energy topics of Kavli lectures at American Chemical Society meeting
3. Neurochemical traffic signals may open new avenues for the treatment of schizophrenia
4. New chemical approach to treat Alzheimers
5. Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens
6. Save the date: American Chemical Society National Meeting, Sept. 8-12, 2013, in Indianapolis
7. Evonik Industries Selects OPX Biotechnologies for Joint Development of Bio-Based Chemicals
8. R. Graham Cooks wins Dreyfus Prize in the Chemical Sciences
9. American Chemical Society resource connects scientists, discoveries, chemistry & biology interface
10. Scientists map all possible drug-like chemical compounds
11. Middle-schoolers discover novel chemical bond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... will present at the LEERINK Partners 6th Annual Global ... on Wednesday, February 15, 2017 at 10 a.m. Eastern ... presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  The ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:2/6/2017)... , Feb. 6, 2017 According to ... are driving border authorities to continue to embrace ... there are 2143 Automated Border Control (ABC) eGates ... deployed at more than 163 ports of entry ... to 2016 achieving a combined CAGR of 37%. ...
(Date:2/3/2017)... -- A new independent identity strategy consultancy firm announces ... Designed to fill a critical niche in technical and ... Mark Crego and Janice Kephart ... expertise that span federal governments, the 9/11 Commission, private ... expertise has a common theme born from a shared ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... 28, 2017 Sangamo Therapeutics, Inc. (NASDAQ: ... reported its fourth quarter and full year 2016 ... this year we rebranded our company as Sangamo ... genomic therapies using our industry leading platform technologies ... cell therapy," said Sandy Macrae , CEO ...
(Date:2/28/2017)... , February 28, 2017 The ... for assessment are the following equities: ZIOPHARM Oncology Inc. (NASDAQ: ... AUPH ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... companies belong to the Healthcare sector, which was narrowly mixed ... Health Care Index declining less than 0.1%, while shares of ...
(Date:2/27/2017)... , February 27, 2017 A Europe-wide ... indicated that researchers using animals in their research treat them with ... 26 countries, and detailed analysis of the results indicates that there ... to put into practice the principles of the 3Rs ... ...
(Date:2/27/2017)... CITY, Calif. , Feb. 27, 2017 /PRNewswire/ ... pharmaceutical company focused on the development and commercialization ... acute pain, announced today the U.S. Food and ... Drug Application (NDA) under section 505(b)(2) for DSUVIA™ ... the treatment of patients with moderate-to-severe acute pain ...
Breaking Biology Technology: