Navigation Links
Charting the epigenome
Date:4/17/2008

n since we still have a very poor understanding of the genome-wide regulation of methylation and its effect on the transcriptome, explains postdoctoral researcher and co-first author Ryan Lister, Ph.D.

The transcriptome encompasses all RNA copies or transcripts made from DNA. The bulk of transcripts consists of messenger RNAs, or mRNAs, that serve as templates for the manufacture of proteins but also includes regulatory small RNAs, or smRNAs. The latter wield their power over gene expression by literally cutting short the lives of mRNAs or tagging specific sequences in the genome for methylation.

But before Lister could start to unravel the multiple layers of epigenetic regulation that control gene expression, he had to pioneer new technologies that allowed him to look at genome-wide methylation at single-base resolution and to sequence the complete transcriptome within a reasonable timeframe.

Collaborating scientists at the ARC Centre of Excellence in Plant Energy Biology at the University of Western Australia in Perth developed a powerful, web-based genome browser, which played a crucial role in unlocking the information hidden in the massive datasets.

Cells employ a whole army of enzymes that add methyl groups at specific sites, maintain established patterns or remove undesirable methyl groups. When Lister and his colleagues compared normal cells with cells lacking different combination of enzymes they discovered that cells put a lot of effort in keeping certain areas of the genome methylation-free.

On the flipside, the Salk researchers found that when they knocked out a whole class of methylases, a different type of methylase would step into the breach for the missing ones. This finding is relevant for a new class of cancer drugs that work by changing the methylation pattern in tumor cells.

You might succeed in removing one type of methylation but end up with increasing a different type, says Ecker. But ve
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. $10 million gift to support cutting-edge epigenome center at USC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
(Date:7/2/2015)... 2015 Research and Markets( ... "Next Generation Biometrics Market by Application, Technology, Function & ... their offering. The next generation biometrics market ... a CAGR of 17.9% between 2015 and 2020 ... the market. Safran SA ( France ...
(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... conservation efforts may have boosted the number of marine turtles ... , New research by the University of Exeter and Marine ... 2007), analyses 100 years of data. It shows an increase ... UK and French waters in the last twenty years. The ...
... UC San Diego have discovered that iron-containing nanoparticles being ... toxic to nerve cells and interfere with the formation ... essential nutrient for mammals and most life forms and ... said Sungho Jin, a professor of materials science at ...
... pulls out a tube. "This is a great one," she says, ... branch is speckled with white fluff. "It's growing really well," she ... close to his eye. "Yes," he says, with a boyish grin, ... fungus success story means nothing is growing at the back of ...
Cached Biology News:US conservation efforts bring more marine turtles to UK 2Widely used iron nanoparticles exhibit toxic effects on neuronal cells 2Widely used iron nanoparticles exhibit toxic effects on neuronal cells 3Fungal factories may save hemlock forests 2Fungal factories may save hemlock forests 3
(Date:7/6/2015)... UK (PRWEB) , ... July 06, 2015 , ... ... other medical fields holds potential to reveal how blood flows in the brain ... damage to the brain. , A new article published in the journal ...
(Date:7/6/2015)... Wellesley, Mass. (PRWEB) , ... July 06, 2015 ... ... development of simpler and cheaper molecular diagnostic tests are key drivers of the ... projected growth of personalized medicine and the introduction of new companion diagnostic tests ...
(Date:7/5/2015)... NY (PRWEB) , ... July 06, 2015 , ... For ... If a user had a high-end machine such as a Varian Cary 4000-7000, a ... So widespread was this design that even NIST used them for their SRM-2031 series ...
(Date:7/3/2015)... , July 3, 2015 ... till 22 september 2015 på  http://www.openinnovationinscience.at ... Innovation in Science" som hålls i ... en färsk undersökning med internationella forskare och ... (LBG) är hälsovetenskapens två största utmaningar bristen ...
Breaking Biology Technology:Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 2FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3
... Janssen Biotech, Inc. announced today that the ... Complete Response letter for its supplemental Biologics License ... in September 2010, seeks to expand the SIMPONI® ... structural damage, inducing major clinical response (MCR) and ...
... Calif., July 22, 2011 NeurogesX, Inc. (Nasdaq: ... novel pain management therapies, today announced that on July ... in connection with a private placement to a group ... conditions, is expected to receive approximately $20 million in ...
... (previously known as the Beijing Genomics Institute), the largest ... Zoology, Chinese Academy of Sciences, together published the whole ... ) in Genome Biology on July 6th, ... for evolutionary and biomedical research. Rhesus macaque, also ...
Cached Biology Technology:FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 2FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 3FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 4FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 5FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 6NeurogesX, Inc. Announces $20 Million Private Placement 2NeurogesX, Inc. Announces $20 Million Private Placement 3NeurogesX, Inc. Announces $20 Million Private Placement 4Whole sequence variation map reveals insight into evolutionary studies of rhesus macaque 2
... EVO Clinical is Tecans open platform for ... quality, safety and performance in the clinical ... provided by flexible barcode reading and sample ... that the system complies with the IVD-Directive* ...
... HRP Conjugate Stabilizer is an aqueous solution ... other non-toxic stabilizing chemicals in a MOPS ... 6.7. This product contains a combination ... ppm Proclin 300 (Rohm and Haas Company) ...
A collection of 42 spots with normal tissues from different organs of C57 mice, rat and human....
... Gene Frame® has been specifically designed ... feature the same dual strength adhesive ... range for easy removal after use. ... there are three sizes available. ...
Biology Products: