Navigation Links
Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy
Date:2/3/2013

tes BRCA1 at a break and the non-homologous end-joining tool repairs the break.

This mechanism can help explain resistance to a promising chemotherapy called PARP inhibition seen in patients and mouse models with BRCA1 mutations. Work from several other research teams surprisingly has shown that if neither BRCA nor 53BP1 are available, then the homologous recombination system goes into action even in the absence of BRCA1 and BRCA1 mutant cancer cells become resistant to PARP inhibitors.

Because of this, Greenberg says, there are some possible applications for making PARP chemotherapy more sensitive: "If you could inhibit specific acetylation events, then a patient's response to PARP inhibitors might be enhanced by hyperactivating 53BP1 binding to breaks in the context of BRCA1 deficient cancers. What's more, measuring the levels of acetylation at H4 might predict how responsive an individual is to PARP inhibitors."

"The story didn't fall into place the way we thought it would," says Greenberg. "We didn't realize that it was a combination of two epigenetic marks that drives the repair system. However, we were able to show that 53BP1 doesn't bind well to regions of histone H4 that are acetylated at a specific location on H4. Collaboration with Georges Mer, a structural biologist at the Mayo Clinic, helped provide the molecular basis for these findings. We think there will be further complexity to this regulation, creating the possibility for the discovery of additional mechanisms that regulate DNA repair pathways and response to therapy and potential new targets for diagnosis and therapy."


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Holding a mirror to brain changes in autism
2. How old are these rocks, how were they made, and how long ago did these geologic changes happen?
3. Scientists find that neurological changes can happen due to social status
4. Changes in brains blood flow could cause brain freeze
5. Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease
6. Nature: Molecule changes magnetism and conductance
7. New research finds increased growth responsible for color changes in coral reefs
8. New milestone book documents changes in the south Florida marine ecosystem
9. Height, weight and BMI changes seen in children treated with peginterferon alpha for hepatitis C
10. Changes in water chemistry leave lake critters defenseless
11. Major changes needed to protect Australias species and ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/5/2014)... Dec. 4, 2014  Tute Genomics, a leader in ... in Series A1 funding led by UK-based Eurovestech. Peak ... in the investment round. "We are at ... adopts next-generation sequencing and seeks new approaches for the ... Robison , MD MBA, and CEO of Tute Genomics. ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... Ireland, the number of people surviving the disease in the ... year there are between 50-60 men and women who survive ... The survival rates in Northern Ireland for cancers including ... and its patients are benefiting from improved treatment outcomes by ...
... This release is available in German . According ... the Lily of the Valley scent known as Bourgeonal alters the calcium ... Valley phenomenon" also the title of a book about smelling ... swimming olfactory cells which follow a "scent trail" laid by the egg. ...
... the aid of light: this is made possible ... of neurobiological processes with unprecedented spatial and temporal ... light-activated protein channelrhodopsin. Biophysicists from Bochum and Berlin ... through an interdisciplinary approach. The researchers report on ...
Cached Biology News:More people surviving cancer in Northern Ireland 2The end of the 'Lily of the Valley phenomenon' in sperm research? 2The end of the 'Lily of the Valley phenomenon' in sperm research? 3Optogenetic tool elucidated 2
(Date:12/24/2014)... SILVER SPRING, Md. , Dec. 24, 2014 ... ) announced today that Medtronic, Inc. (NYSE: ... application to the U.S. Food and Drug Administration ... II implantable drug infusion system (including a ... Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... 23, 2014 GMO corn cases filed ... Syngenta, are in the process of being consolidated in ... case is In Re: Syngenta AG MIR 162 Corn ... for the District of Kansas. , Management of the ... over to U.S. District Judge John W. Lungstrum.* , ...
(Date:12/24/2014)... December 23, 2014 The ... such as its definition, classification, application and ... specification, manufacturing process, and product cost structure. ... applications. The analysis also covers upstream raw ... industry development trend and proposals. In the ...
(Date:12/24/2014)... , Dec. 23, 2014 Vermillion, ... focused on gynecologic disease, announced today that investors ... , Birchview Fund LLC and several Vermillion directors ... unregistered shares of Vermillion,s common stock and warrants ... in a private placement.  Under ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... now lost as heat during the production of ... silicon nanowires synthesized via a technique developed by ... Lawrence Berkeley National Laboratory (Berkeley Lab) and the ... potential applications of this technology include DOEs hydrogen ...
... NEW YORK, January 10 HealthCare Technologies,Ltd., (the ... dated,January 7, 2008 from the Staff of the ... Stock Market LLC, which indicated,that because the Staff ... Biofuels, Inc., which closed on December 31, 2007, ...
... Seven Summits Research issues,PriceWatch Alerts for key stocks., ... at, http://www.iotogo.com/s/011008B (Note: You may have ... [ENTER] key.), Today,s PriceWatch Alerts cover the following ... & Co., Inc. (NYSE: MER ), DryShips, Inc. ...
Cached Biology Technology:Feeling the heat 2Feeling the heat 3Feeling the heat 4HealthCare Technologies Ltd. (NASDAQ: HCTL) Announces Receipt of NASDAQ Delisting Notice 2Seven Summits Research Releases Alerts on XOM, MER, DRYS, CSC, and PDLI 2Seven Summits Research Releases Alerts on XOM, MER, DRYS, CSC, and PDLI 3
... Imaging Systems group announces the availability ... Imaging Systems, featuring high resolution cooled ... luminescence, radiographic and chromogenic imaging capability. ... and 10x optical zoom lens provides ...
... that oxidative stress is involved in atherosclerosis, ... is the condition in which an imbalance ... leading to the damage of a cell. ... is through several antioxidant systems4 that include ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential Neurological liabilities of compound...
Compound(s) screened through any number of client selected assays. Client also selects number of concentrations and replicates....
Biology Products: