Navigation Links
Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy
Date:2/3/2013

PHILADELPHIA - Double-strand breaks in DNA happen every time a cell divides and replicates. Depending on the type of cell, that can be pretty often. Many proteins are involved in everyday DNA repair, but if they are mutated, the repair system breaks down and cancer can occur. Cells have two complicated ways to repair these breaks, which can affect the stability of the entire genome.

Roger A. Greenberg, M.D., Ph.D., associate investigator, Abramson Family Cancer Research Institute and associate professor of Cancer Biology at the Perelman School of Medicine, University of Pennsylvania, together with postdoctoral researcher Jiangbo Tang Ph.D. and colleagues, found a key determinant in the balance between two proteins, BRCA1 and 53BP1, in the DNA repair machinery. Breast and ovarian cancer are associated with a breakdown in the repair systems involving these proteins. Their findings appear in the latest online issue of Nature Structural & Molecular Biology.

The two proteins, BRCA1 and 53BP1, control which of two cell-repair mechanisms will be used: homologous recombination or non-homologous end-joining, technically speaking. This competition has proven to be a key factor in determining whether a cell becomes cancer prone as well as how a cancer cell will respond to chemotherapy.

The key step of the balance is acetylation, the chemical process of adding a compound called an acetyl group to other cellular molecules.

The researchers asked what cell signals determine whether BRCA or 53BP1 predominates at a DNA break site.

DNA in the nucleus is tightly packed around proteins called histones. Acetylation at a specific spot on histone H4 determines the answer. If H4 is acetylated at a specific location, then 53BP1 binding near the broken DNA region is strongly reduced. This leaves BRCA1 free to do the work, kicking in the homologous recombination tool to repair the break.

On the other hand, if acetylation is reduced, 53BP1 outcompe
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Holding a mirror to brain changes in autism
2. How old are these rocks, how were they made, and how long ago did these geologic changes happen?
3. Scientists find that neurological changes can happen due to social status
4. Changes in brains blood flow could cause brain freeze
5. Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease
6. Nature: Molecule changes magnetism and conductance
7. New research finds increased growth responsible for color changes in coral reefs
8. New milestone book documents changes in the south Florida marine ecosystem
9. Height, weight and BMI changes seen in children treated with peginterferon alpha for hepatitis C
10. Changes in water chemistry leave lake critters defenseless
11. Major changes needed to protect Australias species and ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Changes to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy
(Date:3/18/2015)... As mobile payments become more prevalent ... and apps continue to be introduced into the market place ... payment industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... BABA ), Apple Inc. (NASDAQ: AAPL ), Google ... FB ) NXT-ID, Inc. (NASDAQ: ...
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/11/2015)... 11, 2015   The Sync Project™ ... scientifically measure and harness music to improve health. ... and objective measurements of physiology, enabling the study ... in large populations. It is designed for medical ... perform rigorous studies and accelerate the discovery of ...
Breaking Biology News(10 mins):Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3
... Chicago Stritch School of Medicine have received a five-year, ... to study vitamin D deficiency in people of African ... vitamin D levels and risks for certain chronic diseases, ... previous studies is "inconclusive and needs to be studied ...
... and the United States recently published their joint findings that ... have a hidden signature. Findings published this month in ... , demonstrate that up to seven months before an animal ... prion protein in the brain was being eradicated. This member ...
... be used to reduce levels of carbon dioxide in the ... suck in carbon dioxide from the air are being developed ... Edinburgh, with funding from the RCUK Energy Programme, led by ... one 1m2 unit containing the tiny tubes could adsorb (suck ...
Cached Biology News:Loyola receives NIH grant to study vitamin D deficiency in African populations 2Medical researchers in Canada and the US discover hidden side of prion diseases 2Collecting carbon in a concrete jungle 2
(Date:3/25/2015)... Md. , March 25, 2015 Accelovance, ... named a finalist for "Best Contract Research Organization" at ... the World Vaccine Congress. This is ... a finalist for the award, winning for "Best Contract ... a "Highly Recommended" distinction in 2013. "We,re ...
(Date:3/25/2015)... London, UK (PRWEB) March 25, 2015 ... of natural ingredients in all forms of food nutrients, ... led to a substantial rise in demand for natural ... astaxanthin have started to ramp up their capacities to ... for both natural and synthetic source astaxanthin (used in ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 Data ... Novel Mechanism of Action in Neuromuscular Diseases ... – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the publication ... muscle troponin activator tirasemtiv in the journal Neurotherapeutics. ... IIa “Evidence of Effect” or hypothesis-generating clinical trial ...
(Date:3/25/2015)... Researchers at Ancon Medical Inc. ... will enable broader and less invasive screening for ... simple breath screen. The Minnesota-based medical device maker ... Drug Administration (FDA) approval process and is targeting ... Biomarker Tagging device. , Ancon Medicals nanoparticle breakthrough ...
Breaking Biology Technology:Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 3
... be as innocent as a choked calendar, legislative progress has ... of the cable television industry for statewide video franchises. The ... new technologies to the market, passed the Assembly ... it has been gathering dust in the Senate . ...
... who built and rebuilt technology-based companies in Wisconsin, is the ... be presented June 13 at the Wisconsin Entrepreneurs' Conference ... personal health challenges in recent years, will accept the award ... Regency. , ,Eddy, who has been involved in the technology ...
... forms of cancer, ovarian cancer is one of ... federal government is providing incentives for companies to develop methods ... of the beneficiaries. , , NeoClone Biotechnology International , which ... landed a $750,000 federal contract to continue research into biological ...
Cached Biology Technology:In a fast-paced economy, lawmakers must pick up speed 2In a fast-paced economy, lawmakers must pick up speed 3
Rabbit anti-NFkB p105/p50 (Ser337) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
CD69/CD3 50 tests...
Biology Products: