Navigation Links
Changes in gene may stunt lung development in children
Date:3/26/2009

PITTSBURGH, March 26 Mutations in a gene may cause poor lung development in children, making them more vulnerable to diseases such as chronic obstructive pulmonary disease (COPD) later in life, say researchers at the University of Pittsburgh Graduate School of Public Health and the German Research Center for Environmental Health. Their study, published online in Physiological Genomics, measured expression levels of the gene and its variants in both mouse lungs and children ages 9 to 11.

Study authors, led by George Leikauf, Ph.D., professor of occupational and environmental health at the University of Pittsburgh Graduate School of Public Health, and Holger Schulz, M.D., professor of medicine at the Institute of Lung Biology and Disease, German Research Center for Environmental Health, Munich, focused on a gene called superoxide dismutase 3 (SOD3), previously shown to protect the lungs from the effects of asbestos and oxidative stress.

"People lose lung function as they age, so it's important to identify possible genetic targets that control healthy development of the lungs during childhood," said Dr. Leikauf.

Drs. Leikauf, Schulz and colleagues compared SOD3 expression levels in strains of mice with poor lung function to one with more efficient airways and lungs two times the size. As with people, the lungs of mice fully form as they mature to adulthood. The better-functioning strain maintained higher levels of SOD3 levels in these mice were four times higher at the final stage of lung development. They also found the presence of single nucleotide polymorphisms, or SNPs, variations in DNA sequences, in SOD3 that were linked to lung function in mice.

The researchers went on to assess SOD3 mutations in children ages 9 to 11 by testing for SNPs linked to lung function. After analyzing DNA from 1,555 children in Munich and Dresden who were part of the International Study of Asthma and Allergy in Children, they d
'/>"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Old developmental pathways spawn revolutionary evolutionary changes
2. New study shows fish respond quickly to changes in mercury deposition
3. New study shows fish respond quickly to changes in mercury deposition
4. Great Plains historical stability vulnerable to future changes
5. New technique reveals subtle force-induced changes in biomolecules conformation
6. Tolerance to inhalants may be caused by changes in gene expression
7. A new explanation for evolutionary changes in genetic sex-determination systems
8. Hearing changes how we perceive gender
9. UC Davis bird-flu expert calls for changes in early-warning system
10. Elevated carbon dioxide changes soil microbe mix below plants
11. Humans have caused profound changes in Caribbean coral reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... cancer deaths occur because of metastasis, yet progress ... been slow. , "It,s been particularly challenging to ... Gujral, research fellow in systems biology at Harvard ... detected until after they,ve already metastasized." , Gujral ... that should help researchers better understand how metastasis ...
(Date:11/5/2014)... great diversity in their ability to identify scents and ... in their perceptual evaluation of odors, with women outperforming ... , Sex differences in olfactory detection may play a ... to one,s perception of smell, which is naturally linked ... has been suggested to be cognitive or emotional, rather ...
(Date:11/4/2014)... examining only marketing directed at children on the ... found that the majority of black, middle-income and ... tactics. , Authored by Arizona State University researcher ... the first to examine the use of child-directed ... food restaurants and its relationship to demographics. It ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
... Manhattan, but no group takes credit. The pressure on ... sketchy information, the president orders an attack, but it ... wrong country. Things go downhill from there. , To ... 12 scientists with extensive nuclear expertise, headed by Stanford ...
... French. , Hunted to near extinction, ... Pacific coast. Their reintroduction, however, is expected to reduce ... shellfish dramatically, such as sea urchins and geoducks. ... an NSERC-funded researcher at the University of British Columbia, ...
... is available in French . , For more ... of Toronto to rev up the production of stem cells and ... embryonic stem cells. The end products are blood and heart cells ... beating tissue. To do this, he has been applying ...
Cached Biology News:Group led by Stanford physicist says there's an urgent need for nuclear detectives 2Group led by Stanford physicist says there's an urgent need for nuclear detectives 3From stem cells to organs: The bioengineering challenge 2
(Date:11/27/2014)... (PRWEB) November 27, 2014 Spartan Bioscience ... of Food and Drug Safety (MFDS) regulatory approval for ... provides genetic results in less than 60 minutes from ... indicated as an aid for doctors to determine therapeutic ... pathway. These include some of the world’s most commonly ...
(Date:11/26/2014)... The report on the Global Smart Sensor ... market for revenue forecasts and market trends. It expects ... from 2013 to 2018. At the projected rate, the ... million by 2018. , Browse through the Global Smart ... about the market segmentation and in-depth analysis supported by ...
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 /PRNewswire-USNewswire/ ... unforgiving environments. Human exploration of space requires astronauts to ... mission safety and success, and prevent potential errors and ... success, little is known about how cognition is affected ... primarily affected. Now, Penn Medicine researchers are ...
(Date:11/26/2014)... NJ (PRWEB) November 25, 2014 ... has officially joined the Morris County (New Jersey) ... which is a leading business organization in the ... opportunity to further engage some key clients in ... operations in the geographic area. Membership enables Whitehouse ...
Breaking Biology Technology:Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 2Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 4Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3
... ... Manufacture and Testing of Drug Products Imported to the European Union. , ... Toronto, Ontario (PRWEB) February ... leading pharmaceutical companies, today announced successful completion of its recent Health Canada audit. The ...
... , FORT LAUDERDALE, Fla. , ... published in EuroIntervention (EuroIntervention, 2010; 5:698-702) demonstrated ... and no late stent thrombosis at one year in ... percutaneous coronary intervention (PCI) and implantation of the company,s ...
... , EMERYVILLE, Calif. , Feb. 1 ... has appointed Ted W. Love , M.D., Executive Vice President ... , M.D., Ph.D., who has served as Interim Chief Medical Officer ... reporting to Dr. Love.   , In his new role, Dr. ...
Cached Biology Technology:Dalton Pharma Services Announces Successful Completion of Health Canada Inspection 2Dalton Pharma Services Announces Successful Completion of Health Canada Inspection 3OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Good Safety and Clinical Outcomes in Patients with Primary PCI for STEMI 2OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Good Safety and Clinical Outcomes in Patients with Primary PCI for STEMI 3Onyx Pharmaceuticals Appoints Ted W. Love, M.D., as Head of Research & Development 2Onyx Pharmaceuticals Appoints Ted W. Love, M.D., as Head of Research & Development 3Onyx Pharmaceuticals Appoints Ted W. Love, M.D., as Head of Research & Development 4Onyx Pharmaceuticals Appoints Ted W. Love, M.D., as Head of Research & Development 5
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
...
...
Biology Products: