Navigation Links
Changes in brain's blood flow could cause 'brain freeze'
Date:4/22/2012

SAN DIEGO 'Brain freeze' is a nearly universal experiencealmost everyone has felt the near-instantaneous headache brought on by a bite of ice cream or slurp of ice-cold soda on the upper palate. However, scientists are still at a loss to explain this phenomenon. Since migraine sufferers are more likely to experience brain freeze than people who don't have this often-debilitating condition, brain freeze may share a common mechanism with other types of headaches, including those brought on by the trauma of blast-related combat injuries in soldiers. One possible link between brain freeze and other headache types is local changes in brain blood flow.

In a new study, Melissa Mary Blatt, Michael Falvo, and Jessica Jasien of the Department of Veterans Affairs New Jersey Health Care System, Brian Deegan and Gearold O Laighin of the National University of Ireland Galway, and Jorge Serrador of Harvard Medical School and the War Related Illness and Injury Study Center of the Veterans Affairs New Jersey Health Care System use brain freeze as a proxy for other types of headaches. By bringing on brain freeze in the lab in volunteers and studying blood flow in their brains, the researchers show that the sudden headache seems to be triggered by an abrupt increase in blood flow in the anterior cerebral artery and disappears when this artery constricts. The findings could eventually lead to new treatments for a variety of different headache types.

An abstract of their study entitled, "Cerebral Vascular Blood Flow Changes During 'Brain Freeze,'" will be discussed at the meeting Experimental Biology 2012 being held April 21-25 at the San Diego Convention Center. The abstract is sponsored by the American Physiological Society (APS), one of six scientific societies sponsoring the conference, which last year attracted some 14,000 attendees.

Bringing on Brain Freeze

According to study leader Serrador, previous studies meant to assess what physiological changes might prompt headaches have mainly relied on various drugs, or brought in patients already in the throes of a migraine to the lab. However, both methods have their limitations. Pharmacological agents can induce other effects that can make research results misleading, he says, and since researchers can't wait for migraine sufferers to experience a migraine in the lab, those studies miss the crucial period of headache formation that occurs sometimes hours before scientists were able to study these patients.

To induce headache inside the lab and study it from start to finish, Serrador explains, brain freeze is a perfect fit. It's easy to bring on and resolves quickly without expensive or complicated equipment or drugs.

In this study, Serrador and his colleague recruited 13 healthy adults. The researchers monitored the volunteers' blood flow in several brain arteries using transcranial Doppler while they first sipped ice water with the straw pressed against their upper palateideal conditions for bringing on brain freezeand then while sipping the same amount of water at room temperature. The volunteers raised their hand once they felt the pain of a brain freeze, then raised it again once the pain dissipated. Findings showed that one particular artery, called the anterior cerebral artery, dilated rapidly and flooded the brain with blood in conjunction to when the volunteers felt pain. Soon after this dilation occurred, the same vessel constricted as the volunteers' pain receded.

Changing the Course of Headaches

Serrador and his colleagues speculate that the dilation, then quick constriction, may be a type of self-defense for the brain. "The brain is one of the relatively important organs in the body, and it needs to be working all the time," he explains. "It's fairly sensitive to temperature, so vasodilation might be moving warm blood inside tissue to make sure the brain stays warm." But because the skull is a closed structure, Serrador adds, the sudden influx of blood could raise pressure and induce pain. The following vasoconstriction may be a way to bring pressure down in the brain before it reaches dangerous levels.

He notes that similar alterations in blood flow could be at work in migraines, posttraumatic headaches, and other headache types. If further research confirms these suspicions, then finding ways to control blood flow could offer new treatments for these conditions. Drugs that block sudden vasodilation or target channels involved specifically in the vasodilation of headaches could be one way of changing headaches' course.


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
American Physiological Society
Source:Eurekalert

Related biology news :

1. Scientists find that neurological changes can happen due to social status
2. How old are these rocks, how were they made, and how long ago did these geologic changes happen?
3. Holding a mirror to brain changes in autism
4. New research shows childhood adversity causes changes in genetics
5. ChromaDex® Announces Management Changes
6. The influence of estrogen on female mood changes
7. Team finds a better way to gauge the climate costs of land use changes
8. Upper atmosphere facilitates changes that let mercury enter food chain
9. Paleoclimate record points toward potential rapid climate changes
10. Study of Yellowstone wolves improves ability to predict their responses to environmental changes
11. Study finds climate changes faster than species can adapt
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces a presentation by ... Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present ...
(Date:10/9/2017)... Charlotte, N.C. (PRWEB) , ... October 09, 2017 , ... ... Purple announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and ... Dr. Stubbs was a member of the winning team for the 2015 Breakthrough Prize ...
(Date:10/7/2017)... Seattle, WA (PRWEB) , ... ... ... the industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome ... the ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the ... from around the world, is giving back to cancer research with a month-long promotion ... , Now through October 31, shoppers can use promo code PinkRibbon to get 10 ...
Breaking Biology Technology: