Navigation Links
Changes in brain function in early HIV infection: A reliable indicator of disease prognosis?

New Rochelle, NY, October 6, 2011Measurable changes in brain function and communication between brain regions may be a consequence of virus-induced injury during the early stages of human immunodeficiency virus (HIV) infection. These abnormalities and their implications in disease prognosis are detailed in an article in the groundbreaking new neuroscience journal Brain Connectivity, a bimonthly peer-reviewed journal published by Mary Ann Liebert, Inc.

Diminished cognitive function will develop in about half of individuals infected with HIV, which may include deficits in memory, attention, psychomotor capabilities, or verbal fluency. Evidence of cognitive decline in HIV infection has implications for prognosis, reduced survival time, and increased risk of death.

Xue Wang and colleagues from Northwestern University (Chicago and Evanston, IL) and North Shore University Health System (Evanston), used functional magnetic resonance imaging (fMRI) to obtain blood-oxygen-level-dependent measurements in multiple brain regions that yield information on resting-state brain connectivity. They compared the measurements collected in HIV-infected (less than 1 year) and healthy subjects. The authors report "prominent changes" between the two groups in the functional connectivity of visual networks, which have a role in visuo-motor coordination. Based on these findings, they conclude that functional connectivity measurements may be a useful, noninvasive tool for identifying neurological involvement and central nervous system injury early in the course of HIV infection. The findings from the NIH-funded Chicago Early HIV Infection Study are presented in the article, "Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection."

"These findings indicate that changes in brain function are occurring very early in HIV infection, and subclinical alterations in functional connectivity may reflect vulnerability to cognitive decline," says Ann Ragin, PhD, Principal Investigator and Research Professor, Northwestern University Medical School, Chicago, IL.


Contact: Julia Chapman
914-740-2100 x2147
Mary Ann Liebert, Inc./Genetic Engineering News

Related biology news :

1. Research reveals how dynamic changes in methylation can determine cell fate
2. Epigenetic changes dont last
3. Pitt team finds molecular evidence of brain changes in depressed females
4. Revolutionary changes to the Botanical Code published in 16 journals and 5 languages
5. Parasite loads an underlying cause of salmon mortality, linked to land use changes
6. Gastric bypass surgery changes food preferences
7. Environs prompt advantageous gene mutations as plants grow; changes passed to progeny
8. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
9. Changes in brain circuitry play role in moral sensitivity as people grow up
10. UofL researchers replicate human kidney gene changes in mouse model
11. Tiny variation in 1 gene may have led to crucial changes in human brain
Post Your Comments:
Related Image:
Changes in brain function in early HIV infection: A reliable indicator of disease prognosis?
(Date:5/12/2016)... , May 12, 2016 , ... published the overview results from the Q1 wave of ... recent wave was consumers, receptivity to a program where ... with a health insurance company. "We were ... share," says Michael LaColla , CEO of Troubadour ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: ... area for financial services, but it also plays a fundamental ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Sequenom, Inc. (NASDAQ: SQNM ), a life ... development of innovative products and services, announced today that ... denied its petition to review decisions by ... Patent No. 6,258,540 (",540 Patent") are not patent eligible ... Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  In ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
Breaking Biology Technology: