Navigation Links
Changes in brain chemicals mark shifts in infant learning
Date:10/26/2009

tudies reported in the current paper, the authors focused on neurotransmitters in the brain, then manipulated those chemical messages to mimic their natural effects in rats.

They conditioned the rat pups to associate a new odor with a negative eventa mild electric shock. In adult rats, but not in immature rats, a shock induces a telltale increase in levels of the stress hormone corticosterone. Increased corticosterone, in turn, causes the amygdala, a learning center in the brain, to have increased levels of the neurotransmitter dopamine.

Using microarrays (to detect changes in dopamine-related gene expression) and microdialysis (to measure changes in dopamine levels), the study team confirmed that changes in dopamine levels were linked to changes in learning patterns.

On about their tenth day of life, rat pups start to make the transition from preference learning to aversion learning. Based on their corticosterone/dopamine findings, Barr and Sullivan were able to chemically manipulate the learning transition. By injecting eight-day-old rat pups with corticosterone, the scientists advanced the animals' learning behaviorsthe young rats avoided the new (shock-associated) odor, just as older rats did. Eight-day-old control rats did not show such avoidance behavior.

Injecting dopamine directly into an eight-day-old rat's amygdala had a similar effect, switching their usual preference learning to aversion learning typical of older animals. The researchers also toggled the switch in the other direction. By blocking dopamine receptors in eight-day-old rats already treated with corticosterone, the rats showed preference learning instead of the aversion learning induced by corticosterone.

The neural mechanisms they found, said Barr, may also apply to infant behavior in dogs, rats and people. "For humans," said Barr, "the findings may shed light on the pathologically strong attachment that children are known to have even for abusiv
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Old developmental pathways spawn revolutionary evolutionary changes
2. New study shows fish respond quickly to changes in mercury deposition
3. New study shows fish respond quickly to changes in mercury deposition
4. Great Plains historical stability vulnerable to future changes
5. New technique reveals subtle force-induced changes in biomolecules conformation
6. Tolerance to inhalants may be caused by changes in gene expression
7. A new explanation for evolutionary changes in genetic sex-determination systems
8. Hearing changes how we perceive gender
9. UC Davis bird-flu expert calls for changes in early-warning system
10. Elevated carbon dioxide changes soil microbe mix below plants
11. Humans have caused profound changes in Caribbean coral reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 1, 2014, 10:20 AM EDT) It may be ... foods over unhealthy higher-calorie foods, according to new research ... Research Center on Aging (USDA HNRCA) at Tufts University ... the journal Nutrition & Diabetes , a brain ... it is possible to reverse the addictive power of ...
(Date:9/1/2014)... ago, electron microscopy revealed the presence of tiny blob-like ... But scientists still don,t know what they do ... believed to be crucial to the life of a ... disease treatment., In the Journal of Cell Biology ... from various backgrounds, from biophysics to cell biology, to ...
(Date:9/1/2014)... Section of the XVIII International Botanical Congress took place ... held every six years and it is where the ... fungi and plants get together to debate and update ... This is the primary product of the meeting, the ... which was published in 2012. The other important product ...
Breaking Biology News(10 mins):Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2
... Works to Strengthen Security for Anyone with ... Sept. 17 Today a,Southwest Airlines pilot ... be screened by,the Transportation Security Administration (TSA) ... demonstration project called,SecureScreen will utilize biometrics to ...
... $24 million in federal funding to establish the University ... CEIN), which will help researchers design safer and more ... to be housed at the California NanoSystems Institute (CNSI) ... nanomaterials on life forms and the interactions of these ...
... Foundation (NSF) and the Environmental Protection Agency (EPA) have ... Implications of NanoTechnology (CEINT) to explore the potential ecological ... as a million times smaller than the head of ... objects made from the same material. These unusual properties ...
Cached Biology News:Southwest Pilots Launch TSA Demonstration Project to Test Biometric Screening 2UCLA, partners establish new center on environmental effects of nanotechnology 2UCLA, partners establish new center on environmental effects of nanotechnology 3UCLA, partners establish new center on environmental effects of nanotechnology 4Duke to lead new NSF, EPA center to study the environmental implications of nanotechnology 2Duke to lead new NSF, EPA center to study the environmental implications of nanotechnology 3
(Date:8/28/2014)... 28, 2014  Next month, executives from clinical trial marketing ... events beginning with Patient-Centered Clinical Trials 2014 , to ... Boston , September 4-5. Patient recruitment experts Bonnie ... Fleishman will share insights on the benefits of employing ... tactics – from media to mobile apps – can be ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
(Date:8/28/2014)... Exciting new work by a Florida State University research ... can take your temperature, emit white light, and convert ... molecule looks like a butterfly. , Biwu Ma, associate ... in the FAMU-FSU College of Engineering, created the molecule ... continued to discover that his creation has many other ...
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3
... 29 Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ... and commercializing proprietary product candidates principally,for use ... the company,s,President and CEO Theodore Schroeder will ... 6 at 1:30pm Eastern Time (10:30am Pacific ...
... U.S. Attorney,s, Office for Eastern District of Pennsylvania and ... Settles State Cases with Connecticut and ... (Nasdaq:,CEPH) announced today it has finalized a previously announced ... Eastern District of,Pennsylvania, the U.S. Department of Justice and ...
... Calif., Sept. 29 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ... Jerry McMahon, Ph.D., chairman and CEO,will present at the ... 9 a.m. Eastern Time at Le Parker Meridien in ... overview, including a discussion,of the development of picoplatin, the ...
Cached Biology Technology:Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at the JMP Securities Third Annual Healthcare Focus Conference 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 3Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 4Poniard Pharmaceuticals to Present at the JMP Securities Healthcare Focus Conference 2
Whole blood is collected from healthy pigs (mixed breed, either sex) at the time of slaughter, refrigerated within 6 hours, processed within 24 hours and frozen at -20ºC....
ANTI S. ENT TOX BC2D...
Human/Mouse/Rat Keap1 MAb (Clone 333116) Protein Family: Transcription Factor Regulators...
Reacts with MBP from human, bovine and rat, epitope 129-138. Reacts weakly with rabbit. Does not react with guinea pig....
Biology Products: