Navigation Links
Chance finding reveals new control on blood vessels in developing brain
Date:1/24/2013

logy invented at UW-Madison by former professor Oliver Smithies (who shared the 2010 Nobel Prize for this discovery).

When Huang grew mice with a "knock out" mutation that blocked cell division among the radial glia, he expected to see abnormalities in the embryonic brain. But the major abnormality was completely unexpected: blood vessels that had already formed had collapsed.

New blood vessels in an embryo generally develop via a two-step process, first growing, and then stabilizing. "If the second step cannot be carried out, the vessels may already be formed, but the organ still cannot get its blood supply because the vessel will regress, or collapse," Huang says.

When blood vessels collapse, neurons start to die, says Huang. Some brain diseases, including Alzheimer's and hemorrhagic stroke, show a similar regression, and Huang says it's possible that the signaling mechanism that he experimentally blocked may play a role in these diseases as well.

Although any clinical treatment is years away, Huang is still basking in the thrill of basic discovery.

"We find that these progenitor and helper cells, the radial glia, regulate blood vessel development, and nobody has found that before." Huang says. "We used a mouse with alterations in genetics that regulate activity in these helper cells in the brain, and were very surprised to see that this had a drastic effect on blood vessel development. Previously it was always thought that these were two separate systems, now we know there is crosstalk between them. It's almost like a new field has opened up."


'/>"/>

Contact: Zhen Huang
z.huang@neurology.wisc.edu
608-263-2469
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chances seen rising for chikungunya outbreaks in NYC, Atlanta, Miami
2. A charismatic new lacewing from Malaysia discovered online by chance
3. Giving ancient life another chance to evolve
4. Jekyll and Hyde bacteria aids or kills, depending on chance
5. Developing world has less than 5 percent chance of meeting UN child hunger target, study estimates
6. Promising new finding for therapies to treat persistent seizures in epileptic patients
7. New findings in the search for genetic clues to insulin production
8. The findings between DNMs and autism provides global view of mutability on human diseases
9. Finding life in the volcanic systems of the Antarctic Polar Front
10. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
11. Stem cell finding could advance immunotherapy for lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Minn. A Mayo Clinic researcher and his collaborators ... up and enhance the process of re-engineering cells for ... uses network biology methods to aid stem cell engineering. ... engineering are described in two back-to-back papers in the ... a broad range of uses for all types of ...
(Date:8/28/2014)... identified the developmental on-off switch for Streptomyces , ... two-thirds of the world,s naturally derived antibiotic medicines. ... it is possible to manipulate this switch to make ... appearing August 28 in Cell , found that ... and a larger protein called BldD ultimately controls whether ...
(Date:8/28/2014)... good examples of complex systems. Their infrastructure equipment ... for cooling, transport to supply fuel, and ICT ... the network chain is interconnected with a wider ... team of UK-based scientists has studied various aspects ... have been published in EPJ B by Gaihua ...
Breaking Biology News(10 mins):New tool aids stem cell engineering for medical research 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3Inter-dependent networks stress test 2
... computer-based text-searching tool developed by UT Southwestern Medical Center ... in a database for similarities, providing a more efficient ... offering scientific journal editors a new tool to thwart ... efficient at flagging publications that are highly similar, said ...
... automated sensors may soon help NOAA scientists better predict ... ice will melt, and whether soggy Pacific storms will ... of NOAAs Unmanned Aircraft Systems program. NOAA recently ... use of the crewless vehicles for wide-ranging research designed ...
... of this message: , About the Ocean Sciences ... Book Hotel Rooms by 4 February 2008 Abstracts and ... Ocean Sciences Meeting , This years meeting will offer ... and Earths water wherever it is found, from mountain ...
Cached Biology News:Computer-based tool aids research, helps thwart questionable publication practices 2Computer-based tool aids research, helps thwart questionable publication practices 3NOAA invests $3 million for unmanned aircraft system testing 2Media advisory -- 2008 Ocean Sciences Meeting 2Media advisory -- 2008 Ocean Sciences Meeting 3Media advisory -- 2008 Ocean Sciences Meeting 4
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... 2014 The ability for organizations to ... will allow individuals to perform at the highest of ... employers looking to compete in this post–recession era. ... trend, as the sector increasingly focuses on the importance ... will have real results on the organization's development and ...
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson Humphrey ... industry veterans to its equity research team in ... ongoing expansion in equity research demonstrates our commitment ... insights to enhance their investment decision making," said ... STRH.  "We continue to make significant investments in ...
(Date:8/28/2014)... , Aug. 28, 2014  Armetheon, Inc. ( ... novel mid- to late-stage cardiovascular drug candidates, today ... its first round of financing. The Series A ... Hercules Bioventures with participation from investors that included ... executive, Dr. Larry Hsu , the founder ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... 7 Medicsight PLC, a subsidiary,of MGT Capital ... industry leader in the,development of Computer-Aided Detection (CAD) ... received approval from the Brazilian regulatory,agency, Agencia Nacional ... David Sumner, Chief Executive of Medicsight, commented: "This ...
... DENVER, Aug. 7 Quest Product Development, ... a $1,000,000 Small Business,Technology Transfer grant by ... the development of a next-generation endoscope. MicroFlex,technology, ... alloys and,micro-actuators that allow active control over ...
... AutoImmune Inc. (OTC,Pink Sheets: AIMM) today reported a net ... the three months ended June 30, 2008, compared with,a net ... diluted, for the,three months ended June 30, 2007. For the ... or $0.01 per share basic and diluted, compared,with net loss ...
Cached Biology Technology:Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 2Medicsight Receives Brazilian State Food and Drug Administration Approval for ColonCAD Software 3NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes 2AutoImmune Inc. Reports 2008 Second Quarter Financial Results 2AutoImmune Inc. Reports 2008 Second Quarter Financial Results 3
... Reagent B - Permeabilisation medium LEUCOPERM ... suspension with Reagent A and then permeabilising ... gives antibodies access to intracellular structures and ... cells intact. Specific formulations reduce background staining ...
... Rabbit polyclonal to JNK1 (phospho T183 + Y185) ... internal domain containing phosphorylated T183/Y185. Reactivity / ... Not yet tested in other species. Background ... including the ERK, JNK, and p38 kinases. The ...
... Dako Target Retrieval Solution, pH 9 ... Tris/EDTA buffer, pH 9, intended for heat-induced ... It is well-suited for use on formalin-fixed, ... Compared with 0.01 mol/L citrate buffer, pH ...
... has been designed to provide a thin film-like barrier ... a slide. This barrier creates the proper surface ... area on the slide. PAP Pen contains a ... It can be removed, if desired, by xylene ...
Biology Products: