Navigation Links
Certain breast cancers have a trait that could be attacked by new therapies
Date:3/27/2013

More than 100 women per day die from breast cancer in the United States. The odds of developing breast cancer increase for women taking hormone replacement therapy to avoid the effects of menopause. New research by University of Missouri scientist Salman Hyder may lead to treatments for breast cancers associated with taking these synthetic hormones. Hyder, along with an international team, found that hormone-therapy-related breast cancer cells have a physical feature that could be attacked by cancer therapies.

"We identified a specific cell membrane protein that blocks cell death in breast cancer cells and allows these cells to grow in response to hormone replacement therapy," said Hyder. "Others have observed an over-abundance of these proteins in a population of breast cancer cells which may explain increased risk of breast cancer in women who consume hormone replacement therapy. Therapies could be developed that would block the activity of these cell membrane proteins, which would make cancer cells more likely to die. The membrane protein is known as PGRMC1."

The proteins identified by Hyder and his colleagues were affected by progestin, one of the hormones given to women to stave off the effects of menopause. Progestin is a synthetic chemical which mimics the hormone progesterone. In hormone replacement therapy, doctors prescribe progestin along with synthetic replicas of the hormone, estrogen.

"Every progestin type that we have tested has negative effects," said Hyder. "A growing body of evidence suggests women should be wary before taking progestin. However, if women take only synthetic estrogens, such as estradiol, it leads to a higher risk of uterine cancer. Hence, the two must be taken together, but even then they seem to still increase cancer risks in post-menopausal women."


'/>"/>

Contact: Tim Wall
walltj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Progesterone may be why pregnant women are more vulnerable to certain infections
2. Mutant champions save imperiled species from almost-certain extinction
3. In an uncertain world, Navy needs science and technology collaboration, chief says
4. TLR1 protein drives immune response to certain food-borne illness in mice
5. NOAA: Gulf of Mexico dead zone predictions feature uncertainty
6. Financial tool considered climate change uncertainty to select land for conservation
7. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
8. Omega-3s inhibit breast cancer tumor growth, study finds
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Cancer risk for African-American women with benign breast disease factors Wayne State finds
11. Triple-negative breast cancer subtypes identified using microRNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... -- While we may still be a few years away from ... to gain instant access to all that ailed his patients, ... tablets for monitoring and measuring our health are cropping up ... a tad Orwellian to some, but a new survey suggests ... opportunities into their healthcare regime. These are some ...
(Date:11/10/2014)... shelves in early 2010, and people have used them ... be tossed into a washing machine without ever having ... though, has come with risks for young children. , ... found that from 2012 through 2013, U.S. poison control ... years of age swallowing, inhaling, or otherwise being exposed ...
(Date:11/7/2014)... Leading Biometric companies aim to provide ... online transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... BABA ), Google Inc. (NASDAQ: GOOG ), Microsoft ... EBAY ) and MasterCard Inc. (NYSE: MA) ... biometric authentication company focused on the growing mobile commerce is ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... of forests may have been the primary cause of the ... and cave lion, according to Durham University scientists. The ... beings were the primary cause of the extinction of mammals ... The research is part of the most comprehensive study ...
... assistant professor of biochemistry with the Fralin Life Science Institute ... the National Science Foundation (NSF) to advance his research on ... Iron is essential for all life. The level of ... and Mycobacterium tuberculosis need. To satisfy their ...
... Tricking honey bees into thinking they have traveled ... their brains, researchers report this month. Their study, in ... the first to identify distance-responsive genes. Foraging ... they communicate in a language humans can decode, said ...
Cached Biology News:Dwindling green pastures, not hunting, may have killed off the mammoth 2Dwindling green pastures, not hunting, may have killed off the mammoth 3Research targets basic metabolism of disease-causing fungi, bacteria 2Brain gene expression changes when honey bees go the distance 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Medarex, Inc.,(Nasdaq: MEDX ) announced today that it ... Emerging Growth Conference in New York City on Tuesday,September ... will be,webcast live and will be available for replay ... the Medarex website via the Internet at, http://www.medarex.com ...
... Leading scientists,from around the world will meet in ... producing life-saving vaccines and,antibodies. More than 125 scientists ... for New Vaccines II: Focus on Respiratory Virus,Diseases" ... The international,scientific workshop is being organized by the ...
... (Amex: PTN ) stated today that the ... Technologies, Inc. (Amex: CTT ),relating to a ... was,false and misleading. The press release issued ... with Palatin Technologies." However, the,Notice of Termination sent ...
Cached Biology Technology:International Scientific Workshop Focuses on New Methods for Vaccine and Antibody Development 2Palatin Technologies Refutes Competitive Technologies Contention of Material Breach 2
... cassette is designed to allow ampicillin selection ... gb2 driving the gene for ampicillin resistance ... Em7 promoter. It mediates higher transcription efficiency ... synthetic polyadenylation signal terminates the ampicillin expression. ...
... cassette is designed to allow ampicillin ... promoter gb2 driving the gene for ampicillin ... the Em7 promoter. It mediates higher transcription ... A synthetic polyadenylation signal terminates the ampicillin ...
... is designed for the fast and simple ... at any position (for the generation of ... is designed to allow neomycin / kanamycin ... combines a prokaryotic promoter (gb2) for expression ...
... Pyronin Y is most widely used ... selectively and differentially stain nucleic acids ... dichromatic dye solution, Pyronin Y stains ... DNA green. Chem comp: ...
Biology Products: