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Center for Clinical and Translational Science awards new pilot grants
Date:5/14/2013

rries the virus for life and can pass it on to others. Over the counter treatments can sometimes speed the healing of cold sores, but nothing can block the virus from entering a cell or spreading. Dr. Tibor Valyi-Nagy, associate professor of pathology, in collaboration with Deepak Shukla, associate professor of ophthalmology and visual science, will use their pilot grant to develop ways to block HSV-1 from entering cells or prevent life-long infection.

Iron absorption, obesity, and colorectal cancer

Obesity is a significant risk factor for developing colorectal cancer, the second leading cause of cancer-related death in the U.S., but how obesity and colorectal cancer are linked is poorly understood. Dr. Lisa Tussing-Humphreys, assistant professor of health promotion research in the department of medicine, and her group will investigate the connection between obesity and absorption of iron in the colon and how those factors may trigger colorectal cancer. They will design a clinical trial to examine the effects of dietary iron on the risk of developing colorectal cancer in obesity.

New targets for treating thrombo-inflammatory disease

Platelets and neutrophils are blood components that play a critical role in clotting and in the development of cardiovascular disease. Jaehyung Cho, assistant professor in pharmacology and anesthesiology, and colleagues have identified an enzyme that helps regulate blood factors. They will use their pilot grant to further investigate how the enzyme may influence the formation of dangerous, artery-blocking clots.

A new approach to treating hemophilia

People with hemophilia have defective or missing clotting factors, and for them, even the smallest cut can become a medical emergency. Standard therapy--replacing missing clotting factors--is expensive and can trigger an allergic response. Dr. Xin Huang, assistant professor in the Center for Molecular Biology of Oral D
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Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

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