A curious twist in a family of plant proteins called chalcone-isomerase recently was discovered by Salk Institute for Biological Studies scientist Joseph Noel and colleagues at Iowa State University led by Eve Wurtele.
Pursuing basic scientific discovery, they found three similar proteins that could soon translate into positive results for bio-renewable fuels, commodity chemicals like plastics, food security and nutrition and biomedicine.
The findings, reported May 13 in advance online publication of the journal Nature, may lead to higher-yield crops and quantities of oils, help to address growing world demands for food and fuel, and mitigate environmental pressures on stressed ecosystems.
Researchers long wondered about the origin and action of the chalcone-isomerase. They knew it played a key role in producing flavonoids--compounds important to plants for many reasons including defense as natural sunscreens and antibiotics, attraction of pollinators and development.
Flavonoids are also valuable in disease prevention agents as nutraceuticals and in plant-rich diets-employed in fighting cancer and other age-related diseases.
Looking into the evolution of the plant protein, the researchers discovered three Chalcone-isomerase cousins that bind fatty acids.
"This is a beautiful study demonstrating that Chalcone-isomerase arose from another important class of proteins, which have no enzymatic activity but bind fatty acids," said Greg Warr, acting deputy director of the National Science Foundation's Division of Molecular and Cellular Biosciences, which funded the study.
"The findings may have important implications for agriculture and biofuel development."
Researchers found the Chalcone-isomerase cousins clustered in something called chloroplasts, specialized parts of a cell that serve as the engines of photosynthesis, but also the key place for making essential fatty acids, including omega
|Contact: Bobbie Mixon|
National Science Foundation