Navigation Links
Cellular renewal process may underlie benefits of omega fatty acids
Date:2/13/2013

es covering many types of animals for shared genes that respond to fasting by changing their expression. She found that expression of the C. elegans gene lipl-4 increases up to seven times in worms not given access to nutrients. A transgenic strain that constantly expresses elevated levels of lipl-4, even when given full access to food, was found to have increased levels of arachidonic acid (AA), an omega-6, and eicosapentanoic acid (EPA), an omega-3 fatty acid and to resist the effects of starvation.

Following the implication that omega fatty acids stimulate a process leading to starvation resistance, the researchers found that feeding AA and another omega-6 fatty acid, but not EPA, activated autophagy in non-transgenic C. elegans with full access to nutrients. Since activation of autophagy has been shown to increase lifespan in several genetic models, the authors tested the effect of omega-6 fatty acids on C. elegans lifespan and found that roundworms consuming a full normal diet supplemented with omega-6 fatty acids lived 20 to 25 percent longer than usual.

Since dietary supplementation with both omega-3 and omega-6 fatty acids has been shown to prevent or improve several human health conditions, the researchers tested the response of cultured human cells to omega fatty acid supplementation. As in C. elegans, the human cells responded to supplementation with the omega-6 acids, but not to EPA, by activation of autophagy, measured by levels of marker proteins. That result suggests that omega-6 acids induce autophagy across the full range of multicellular animal species. The researchers then showed that the lifespan-increasing properties of omega-6 fatty acids in C. elegans depend on the presence of genes required for autophagy.

"Almost all the mechanisms of lifespan extension studied until now sterility, insulin insensitivity, and caloric restriction have been shown to depend on activation of au
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease
2. Cancer suppressor gene links metabolism with cellular aging
3. Cellular fuel gauge may hold the key to restricting cancer growth
4. Study sheds light on how cells transport materials along crowded intercellular highways
5. Long-distance solute transport in trees improved by intercellular pathways in living woody tissues
6. Microchoreography: Researchers use synthetic molecule to guide cellular dance
7. New technique enables high-sensitivity view of cellular functions
8. Cellular landscaping: Predicting how, and how fast, cells will change
9. BioLife Solutions Products Now Used in More than 50 Clinical Trial-Stage Cellular Therapies
10. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
11. Division of labor offers insight into the evolution of multicellular life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Pacific Northwest National Laboratory honored more than ... of intellectual property at PNNL,s annual Intellectual Property ... The Department of Energy national laboratory named materials ... his work developing battery materials that can store ... electrical grid, and reduce the time it takes ...
(Date:5/23/2013)... new mechanism by which estrogen suppresses lipid synthesis in ... new approach toward treating certain liver diseases. , ... they are changing long-held views in the field. Study ... journal Science Signaling . , "The dogma in ... that only receptors located in the nucleus respond to ...
(Date:5/23/2013)... or harsh treatments because science fails to identify ... the disease. Researchers at Case Western Reserve University ... that allows patients to safely choose to do ... drastic measures. , The project is one of ... engineering at Case Western Reserve and director of ...
Breaking Biology News(10 mins):PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2Using big data to identify prostate cancers and best treatments 2Using big data to identify prostate cancers and best treatments 3
... As dog bites become an increasingly major public health concern, a ... bites, that the culprits are usually family pets and if they ... more brutal than the first. The study, the largest of ... of Colorado School of Medicine, who found that dogs usually target ...
... available in Spanish . , U.S. Department of ... improve soil on degraded land so it can be used ... Agricultural Research Service (ARS) at the agency,s Appalachian Farming Systems ... replacement subsoils and topsoils to build better and less-costly sports ...
... Meeting on Acoustics -- a major international acoustics conference ... Coral Beach Hotel in Cancun, Mexico. Reporters are invited ... http://www.acoustics.org/press The press room contains news releases ... more than a thousand presentations at the meeting, which ...
Cached Biology News:Study shows young, unsupervised children most at risk for dog bites 2Improving soil for better lawns and gardens 2Worldwide press room opens for major acoustical science and technology conference, Nov. 15-19 2Worldwide press room opens for major acoustical science and technology conference, Nov. 15-19 3Worldwide press room opens for major acoustical science and technology conference, Nov. 15-19 4Worldwide press room opens for major acoustical science and technology conference, Nov. 15-19 5
(Date:5/24/2013)... Vestiage, Inc. (stock symbol "VEST") a publicly ... and development, sales and marketing of premium branded ... that it is awarding exclusive Vestiage territories in ... Skin Illuminating Facial Care. Qualified applicants can request ... email to info(at)vestiageinc(dot)com and putting RELUMA in the ...
(Date:5/23/2013)... Colo. , May 23, 2013 Venaxis, ... diagnostic company focused on obtaining FDA clearance and commercializing ... today announced the pricing of an underwritten public offering ... warrants to purchase 3,500,000 shares of its common stock ... a combined public offering price of $1.25 per share ...
(Date:5/23/2013)... Patheon Inc ., a leading provider of contract development ... host a complimentary webinar on “Cleaning Validation: Science, Risk ... 2013 at 11 a.m. Eastern Standard Time. , ... for cleaning validation. Many companies have incorporated their ... of risk. Some companies have chosen to avoid ...
(Date:5/23/2013)... Auburn, MA (PRWEB) May 23, 2013 ... one inch wide and provide 15 mm travel ... nanometers. The small dimensions make these new ... in confined spaces. A vacuum rated version is ... Datasheet:, Drawings, specifications and datasheets can be found ...
Breaking Biology Technology:Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 3Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 4Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 5Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2Precision Positioning System Uses Miniaturezed Piezo Linear Motor: LPS-24 Linear Stage by PI 2
... 15 CMS, Inc., an Elekta Company and,worldwide ... today announced the commercial launch of its new ... the Focal product line that also includes FocalSim ... support the,visualization and utilization of 4D image sets ...
... 15 /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), a ... the,initiation of clinical trials in Ukraine for its ... trials are being conducted by,Biolik Biopharmaceutical Company, a ... approval in the Country. Biolik will,also market and ...
... Thriving Student ... MARIETTA, Ga., Sept. 15 Solvay Pharmaceuticals, Inc.,has ... fibrosis (CF) through its SolvayCARES Scholarship program. Each,student has ... education. This fall, one SolvayCARES Scholarship winner,will go on ...
Cached Biology Technology:CMS, Inc., an Elekta Company, Announces Commercial Availability of Focal4D(TM) 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 340 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 240 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 340 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 4
... gun optimization kit provides a variety of ... particle delivery with the Helios gene gun. ... 0.6 micrometer, 1.0 micrometer, and 1.6 micrometer ... kit, that provides 0.5 g polyvinylpyrrolidone (PVP) ...
... of Gene Expression (SAGE) is a ... offers a cost-effective outsourcing solution for ... libraries. Agencourt's SAGE sequencing service provides ... and long Phred20 read lengths (40 ...
... process of determining the nucleotide sequence of ... is based on Sangers enzymatic method with ... sequencing reactions. The resulting fluorescent products are ... controlled by a computer and the Data ...
... maintenance, calibration, and validation (MCV) ... plate used for hands-free startup, ... using the Bio-Plex suspension array ... for use with Bio-Plex Manager ...
Biology Products: