Navigation Links
Cellular origin of a rare form of breast cancer identified
Date:9/22/2011

BOSTON (September 22, 2011) -- Identifying the cellular origins of breast cancer might lead to earlier diagnosis and more efficient management of the disease. New research led by Charlotte Kuperwasser of Tufts University School of Medicine (TUSM) has determined that common forms of breast cancer originate from breast cells known as luminal epithelial cells while rarer forms of breast cancer, such as metaplastic carcinomas, originate from basal epithelial cell types. The study was published online ahead of print this week in PNAS Early Edition as part of its breast cancer special feature.

Clinicians and researchers classify breast cancers into subtypes based on both clinical features and molecular features, including expression of certain genes and proteins. These classifications help determine diagnosis, treatment decisions, and patient prognosis. The most common form of breast cancer, called invasive ductal carcinoma, is classified broadly into two types based on molecular features of the tumor cells: luminal-like cancers, which are sensitive to hormones, and the more aggressive basal-like cancers, which are not sensitive to hormones and tend to have a poorer prognosis.

However, there are also rare forms of breast cancer, some of which are called metaplastic carcinomas, where the cancer cells no longer resemble cells of the breast. Scientists do not yet fully understand how and why these different types of breast cancers form but one theory is that they originate from adult breast tissue stem cells.

"For the past several decades, most research efforts have been focused on discovering cancer-causing genes in hope that this information might help us discover better treatments for breast cancer. While these efforts have led to successes in treating some common forms of breast cancer, they have not provided us with information regarding where breast cancer originates and in particular, the origins of rare forms of metaplastic b
'/>"/>

Contact: Siobhan E. Gallagher
617-636-6586
Tufts University, Health Sciences Campus
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Spiral constriction -- how dynamin mediates cellular nutrient uptake
2. The cellular intricacies of cystic fibrosis
3. Cellular metabolism self-adapts to protect against free radicals
4. New cellular surprise may help scientists better understand human mitochondrial diseases
5. Cellular laser microsurgery illuminates research in vertebrate biology
6. Cellular stress can induce yeast to promote prion formation
7. Researchers provide means of monitoring cellular interactions
8. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
9. How muscle develops: A dance of cellular skeletons
10. Harvard scientists see the early cellular cause of dry eye disease for the first time
11. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the ... was interviewed on July 1 st on the ... . Mr. Pereira discusses the company,s next generation smart wallet ... the Wocket™ aims to replace a traditional wallet with a ... tells Gino he has never heard of the Wocket ...
(Date:7/10/2014)... , July 3, 2014 Research and ... of the "Global Gesture Recognition & Touch-Less ... Forecasts to 2020" report to their offering ... Global Gesture Recognition & Touch-Less Sensing Market to ... for a while, but the companies were unable ...
(Date:7/10/2014)... July 7, 2014 According to ... "Electronic Access Control Systems Market Global Forecast, Market Share, ... global Electronic Access Control systems market was valued at ... grow at a CAGR of 12.6% from 2014 to ... million in 2019. Browse the full Electronic ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... Ore. November 6, 2008. Although the Northwest Forest Plan ... land, forests in the driest regions are now at ... logging. A team of federal and university scientists recently ... discovered that elevated fire levels in the Pacific Northwest ...
... fungus has been found to produce a variety of ... known as Gliocladium roseum (NRRL 50073), lives ... Gary Strobel of Montana State University has found ... the particular diesel components produced can be varied by ...
... Turtles nesting along the Mississippi River and other areas ... temperatures, says a researcher from Iowa State University. ... biology, has studied turtle nesting habits and also accumulated ... habits of the turtles to find out when they ...
Cached Biology News:Wildfires result in loss of forests reserved by Northwest Forest Plan 2Obscure fungus produces diesel fuel components 2Turtles alter nesting dates due to temperature change says ISU researcher 2
(Date:7/10/2014)... Understanding the need for better quality and higher ... that currently exists in this area, ChanTest has recently ... validated ion channel and GPCR cell lines. ChanTest’s ... channels control many critical physiological functions throughout the body. ... to treat a variety of human diseases. , ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Robert Harman, DVM, ... Medicine company, is proud to announce the relaunch of his ... with a new series called “ What are Stem Cells ... an honest and straightforward foundation in the basics of stem ... decision on the right type of treatment when considering regenerative ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
Breaking Biology Technology:Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2
... , BEIJING, China , July 6 ... the development, assembly,marketing and sale of medical devices and homecare medical products in ... EPS for,fiscal year 2010. , , ... (Logo: http://photos.prnewswire.com/prnh/20100422/CNTH001LOGO ) , ...
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, announced today ... by Taconic Artemis and Taconic Farms Inc in December 2008 ... , , , ... of the Tribunal de Grande Instance decided on Tuesday, June 29 ...
... July 6 Novavax, Inc. (Nasdaq: NVAX ... M.D., as the company,s Chief Scientific Officer who will report ... Officer of Novavax.  Previously, Dr. Glenn was Chief Scientific Officer ... international health at Johns Hopkins University,s School of Public ...
Cached Biology Technology:Dehaier Medical Systems Reaffirms Earnings Estimate of $0.80 EPS for FY 2010 2Dehaier Medical Systems Reaffirms Earnings Estimate of $0.80 EPS for FY 2010 3Dehaier Medical Systems Reaffirms Earnings Estimate of $0.80 EPS for FY 2010 4Taconic's Litigation Contesting License Termination By Cellectis Is Dismissed 2Taconic's Litigation Contesting License Termination By Cellectis Is Dismissed 3Novavax Announces Appointment of Dr. Gregory Glenn as Chief Scientific Officer 2Novavax Announces Appointment of Dr. Gregory Glenn as Chief Scientific Officer 3Novavax Announces Appointment of Dr. Gregory Glenn as Chief Scientific Officer 4
Human Cell Line Slides...
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA ...
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Biology Products: