Navigation Links
Cellular metabolism self-adapts to protect against free radicals
Date:9/7/2011

This press release is available in German.

Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen radicals which must be decomposed immediately, as they would otherwise cause damage to cells. Scientists from the Max Planck Institute for Molecular Genetics in Berlin have now discovered a mechanism, with whose help cells can coordinate respiratory activity and the degradation of free radicals. Thus, the cells prepare their metabolism for free radicals before they even arise.

Cellular respiration is a very efficient process through which a lot of energy is generated from a few sugar molecules and oxygen. However, up to two percent of the oxygen used in this process is transformed into superoxide, a free radical that is toxic to cells. A considerable proportion of this superoxide evades the respiratory chain of the mitochondria and poses a threat to biological macromolecules like DNA, RNA, proteins and fatty acids. However, evolution has equipped eukaryotic cells with comprehensive mechanisms that can decompose free radicals which arise in the cell and therefore prevent damage to the cell. These mechanisms work extremely efficiently and are well coordinated so that, contrary to popular belief, the treatment of healthy tissue with natural or synthetic antioxidants can disrupt the natural balance and, at worst, damage cells and accelerate the aging process.

Researchers at the Max Planck Institute for Molecular Genetics compared respiring and non-respiring yeast cells. When respiration was activated, there was a direct increase in the cells' tolerance to oxidised substances; however, contrary to expectation, this was not accompanied by a rise in the concentration of free radicals. This proved that respiring cells are
'/>"/>

Contact: Dr. Patricia Marquardt
patricia.marquardt@molgen.mpg.de
49-308-413-1716
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. New cellular surprise may help scientists better understand human mitochondrial diseases
2. Cellular laser microsurgery illuminates research in vertebrate biology
3. Cellular stress can induce yeast to promote prion formation
4. Researchers provide means of monitoring cellular interactions
5. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
6. How muscle develops: A dance of cellular skeletons
7. Harvard scientists see the early cellular cause of dry eye disease for the first time
8. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
9. WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
10. Extracting cellular engines may aid in understanding mitochondrial diseases
11. New book highlights the cellular and molecular determinants of brain wiring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 Research ... of the "Saudi Arabia Biomedical Sensors Market - ... offering. The Saudi Arabia Biomedical Sensors ... a CAGR of 3.64% over the period 2014-2020 ... are adaptable to the genetic formulation of each individual. ...
(Date:8/26/2015)... 26, 2015 The report "Multi-Factor Authentication ... Factor), Application (Travel & Immigration, Government, Banking, Defense, Commercial ... to 2020", published by MarketsandMarkets, Multi-Factor Authentication Market is ... at a CAGR of 17.7% between 2015 and 2020. ... igures spread through 169 P ...
(Date:8/24/2015)... The consulting company Frost & Sullivan ... DERMALOG and its customized solutions and products for ... the Year Award". DERMALOG is particularly successful with a large ... -Cross reference: Picture is available at AP Images ( ... Thursday evening, in South Africa,s economic ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3
... Association (ISWA) calls the attention of the delegates of ... waste sector to reduce substantial CO 2 -emissions. ... (December 2009, www.iswa.org ) ISWA confirms that significant ... better management of solid wastes (i.e., residential and commercial ...
... TORONTO, Dec. 7 IgeaCare Solutions Inc. is pleased to ... company previously operating as IgeaCare Systems Inc. The newly formed ... funding. , IgeaCare Solutions Inc. has appointed Mr. Michael Rochon ... the new company will focus on providing a superior servicing ...
... have found that a gene already implicated in the ... the risk of being overweight during childhood. The finding ... may present an avenue for developing drugs to counteract ... childhood and adolescence. Researchers from The Children,s Hospital ...
Cached Biology News:ISWA calls attention to important contribution of waste sector to reduce substantial CO2 emissions 2IgeaCare Solutions Inc. Emerges Under New Leadership and Funding 2Type 2 diabetes gene predisposes children to obesity 2
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII ), ... innovative therapies primarily in the areas of dermatology ... period following the filing of the Company,s Investigational ... U.S. Food and Drug Administration (FDA) has passed ... Logo -  http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:8/31/2015)... 2015 Trimb Healthcare AB ("Trimb") today announced ... Group BV ("YouMedical"), a Dutch OTC company with operations ... of approximately EUR 16 million, with solid growth and ... ambition is to build a leading international OTC company, ... goal. YouMedical gives us a stronger North European OTC ...
(Date:8/30/2015)... August 31, 2015 , ...   für chirurgische   Behandlung     ...   werden für eine   verheerende   Geburtsverletzung behandelt ... und die Anzahl ausgebildeter Chirurgen in Kenia bis 2017 ... heute bekannt, dass  Action on Fistula  seit ihrem Beginn ...
Breaking Biology Technology:Mexico Biomedical Sensors Market Report 2015-2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5
Convenient 10X buffer concentrate used to maximize binding to the solid phase in microwell ELISA. Formulated to provide optimal pH and ionic strength for binding of antibodies and some antigens. Co...
... ester can be used to ... The covalently bound acridinium NHS ... the presence of hydrogen peroxide. ... be used as a detection ...
A trigger solution for Flashlight labeled materials....
... shift assay (EMSA) is a powerful tool ... as gel shift or gel retardation, the ... when subjected to electrophoresis, free DNA will ... Pierce LightShift Chemiluminescent EMSA Kit is a ...
Biology Products: