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Cellular mechanical forces may initiate angiogenesis
Date:4/26/2010

BOSTON and CAMBRIDGE (April 26, 2010) Pericytes, the contractile cells surrounding capillaries, may use mechanical forces to initiate angiogenesis, the "sprouting" of new blood vessels, according to researchers at Tufts University School of Medicine (TUSM) and the Massachusetts Institute of Technology (MIT). The study, published in Journal of Physics: Condensed Matter, is among the first to examine mechanical signaling by pericytes as a potential driver of angiogenesis, which is crucial in the progression of cancer, diabetic retinopathy, and age-related macular degeneration.

Previously, scientists have focused on the chemical signals that initiate angiogenesis and have developed drugs to alter these signals. Now, it appears that the mechanical signals from pericytes can also play a role in regulating the sprouting of new blood vessels.

"If we find that mechanical signaling, such as the force exerted by pericytes, initiates angiogenesis, we can explore ways of interfering with these signals. In this in vitro study, we found that pericytes generated contractions that physically altered the microvascular environment. In the body, such local contractions could serve as the initiating, mechanical signals that influence angiogenesis," said co-senior author Ira Herman, PhD, professor of physiology at TUSM.

"Depending on the circumstances, angiogenesis can either promote health or promote disease," he continued. "Angiogenesis is required for early development and wound healing, but it can also feed cancerous tumors or cause vascular complications in the eye. Our goals are aimed at developing drugs that might enhance wound healing angiogenesis while preventing the harmful angiogenesis that leads to tumor growth or vision loss."

Herman and team members at Tufts joined materials scientists and engineers at MIT in this interdisciplinary effort.

"This collaboration enabled us to quantify the role that mechanics plays
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Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

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