Navigation Links
Cellular landscaping: Predicting how, and how fast, cells will change
Date:11/1/2012

rotein involved in building the extracellular support matrix in tissuesby adding a snippet that codes for a small fluorescent molecule. The more a given cell activates or expresses the gene, the brighter it glows under appropriate light. The team then monitored the cell culture under a microscope, taking an image every 15 minutes for over 40 hours to record the fluctuations in cell behavior, the cells waxing and waning in the degree to which they express the fluorescent gene.

Custom software developed at NIST was used to analyze each image. Both time-lapse data from individual cells and time-independent data from the entire population of cells went into a statistical model. The resulting graph of peaks and valleys, called a landscape, says Plant, "mathematically describes the range of possible cell responses and how likely it is for cells to exhibit these responses." In addition, she says, the time analysis provides kinetic information: how much will a cell likely fluctuate between states, and how quickly?

The combination makes it possible to predict the time it will take for a given percentage of cells to change their characteristics. For biomanufacturing, it means a finer control over cell-based processes. If applied to stem cells, the technique could be useful in predicting how quickly the cells differentiate and the probability of having undifferentiated cells present at any point in time.


'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BioLife Solutions Products Now Used in More than 50 Clinical Trial-Stage Cellular Therapies
2. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
3. Division of labor offers insight into the evolution of multicellular life
4. Researchers study knee stress at tissue, cellular levels
5. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
6. BUSM study shows role of cellular protein in regulation of binge eating
7. Groundbreaking discovery of the cellular origin of cervical cancer
8. A non-invasive intracellular thermometer with fluorescent proteins has been created
9. Make or break for cellular tissues
10. Cellular secrets of plant fatty acid production understood
11. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular landscaping: Predicting how, and how fast, cells will change
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Law Enforcement Biometrics Market in North America ... About Biometrics Biometrics is a technology that ... their physical or behavioral patterns. It involves the ... as fingerprints, face recognition, DNA, palm print, hand ...
(Date:8/27/2014)... requires nerve cells to rearrange existing patterns of activity ... patterns, a study of monkeys has found. The scientists ... electrical activity of brain cell networks. The study was ... "We looked into the brain and may have seen ... said Aaron Batista, Ph.D., an assistant professor at the ...
(Date:8/27/2014)... University of Utah biologist agan Sekercioglu, who campaigns to ... nation,s highest science prize, which is similar to the ... five researchers picked for 2014 the top awards by ... Three researchers won the Science Award and two ... equivalent to the Science Award but for scientists who ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Scientists plug into a learning brain 2Scientists plug into a learning brain 3University of Utah biologist wins Turkey's top science prize 2
... Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, ... blood clotting and major bleeding as effectively as warfarin, ... Dabigatran versus warfarin in patients with atrial fibrillation, by ... New England Journal of Medicine , says warfarin ...
... can learn a lot from an animal. By manipulating the ... a great deal about the genes and molecules behind many ... the same in people as they do in "model" animals. ... such as humans, ability to learn language from one another, ...
... with Stroud Water Research Center in Avondale, Pa., has ... Foundation to establish the Christina River Basin as a ... climate change. Scientists define the "critical zone" as ... the groundwater that sustains terrestrial life. The observatory ...
Cached Biology News:Transgenic songbirds provide new tool to understand the brain 2Critical Zone Observatory seeks to answer climate change questions 2Critical Zone Observatory seeks to answer climate change questions 3Critical Zone Observatory seeks to answer climate change questions 4
(Date:8/27/2014)...   MSC , a healthcare performance improvement company ... appointment of Mary Beth Loesch to President ... experience preparing companies for rapid growth and market expansion, ... of Corporate Development and Healthcare. In that role, she ... well as corporate strategy and marketing. Previously, Loesch served ...
(Date:8/27/2014)... Aug. 27, 2014 Research and ... "Global Lactic Acid  (Biodegradable Polymer, Food & Beverage, ... Forecasts to 2019" report to their offering. ... acid with an asymmetrical carbon atom. The main ... polymer, food and beverage, personal care product, and ...
(Date:8/27/2014)... -- Guggenheim Securities, the investment banking and capital markets ... veteran equity analyst Charles "Tony" Butler as a managing ... on the biotech/biopharma sector. " Tony Butler ... a broad network of relationships in his industry," said ... of Equities at Guggenheim Securities. "His insights will further ...
(Date:8/27/2014)... Research and Markets  has announced the addition of ... Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... spectrometer industry. The report provides a basic ... industry chain structure. The isotope ratio mass spectrometer market ...
Breaking Biology Technology:MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... visualized data at the atomic scale. Source: Imago ... Australian facility for nanotechnology research, said it has commissioned ... Corp. , ,NANO officials said they were pleased ... use at the University of Sydney. , ,Imago makes ...
... Thailand and Sri Lanka when the chief disaster coordinator for ... stingy for not providing more relief. Many Americans shrugged off ... Others responded by doing what they would have done, anyway: ... predictable yes, predictable outpouring of private and corporate ...
... the ever-expanding realm of content management systems (CMS) providers, ... things simple for clients. Forget the gearhead techno-speak. The ... and business issues through plain talk and better Web ... use the Web, said Pat Bieser, founder and CEO ...
Cached Biology Technology:Are we stingy on tsunami relief? Not when private giving is counted 2Are we stingy on tsunami relief? Not when private giving is counted 3Untangling the Web: Northwoods Software in profile 2Untangling the Web: Northwoods Software in profile 3Untangling the Web: Northwoods Software in profile 4Untangling the Web: Northwoods Software in profile 5
... pulsed field separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any ... ... ...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
Mouse monoclonal antibody to Lats2....
... Membrane Protein 2, Synaptobrevin 2). ... homology with any other known ... expected that the antibody will ... multata and bovine due to ...
Biology Products: