Navigation Links
Cellular landscaping: Predicting how, and how fast, cells will change
Date:11/1/2012

A research team at the National Institute of Standards and Technology (NIST) has developed a model* for making quantifiable predictions of how a group of cells will react and change in response to a given environment or stimulusand how quickly. The NIST model, in principle, makes it possible to assign reliable numbers to the complex evolution of a population of cells, a critical capability for efficient biomanufacturing as well as for the safety of stem cell-based therapies, among other applications.

The behavior and fate of cells are only partially determined by their DNA. A living cell reacts to both its internal and external environmentthe concentration of a particular protein inside itself or the chemistry of its surroundings, for exampleand those reactions are inherently probabilistic. You can't predict the future of any given cell with certainty.

This inherent uncertainty has consequences, according to NIST biochemist Anne Plant. "In the stem cell area in particular, there's a real safety and effectiveness issue because it's very hard to get 100 percent terminal differentiation of stem cells in a culture," she says. This could be problematic, because a therapist wishing to produce, say, heart muscle cells for a patient, might not want to introduce the wild card of undifferentiated stem cells. "Or effectiveness may be dependent on a mixture of cells at different stages of differentiation. One of the things that is impossible to predict at the moment is: if you waited longer, would the number of differentiated versus nondifferentiated cells change? Or if you were to just separate out the differentiated cells, does that really remove all the nondifferentiated cells? Or could some of them revert back?" says Plant.

The NIST experiments did not use stem cells, but rather fibroblasts, a common model cell for experiments. The team also used a standard tracking technique, modifying a gene of interestin this case, one that codes for a p
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BioLife Solutions Products Now Used in More than 50 Clinical Trial-Stage Cellular Therapies
2. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
3. Division of labor offers insight into the evolution of multicellular life
4. Researchers study knee stress at tissue, cellular levels
5. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
6. BUSM study shows role of cellular protein in regulation of binge eating
7. Groundbreaking discovery of the cellular origin of cervical cancer
8. A non-invasive intracellular thermometer with fluorescent proteins has been created
9. Make or break for cellular tissues
10. Cellular secrets of plant fatty acid production understood
11. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular landscaping: Predicting how, and how fast, cells will change
(Date:8/21/2014)... North Carolina State University have developed a novel and ... has applications for creating new materials as well as ... new technique allows us to model much larger and ... more quickly," says Nan Li, lead author of a ... NC State,s Department of Materials Science and Engineering. "This ...
(Date:8/20/2014)... In a study of 158 pregnant teenagers in ... craving and intentional consumption of ice, cornstarch, vacuum dust, ... a new Cornell study. , Moreover, such teens had ... did not eat nonfood substances. , Pregnant teens, regardless ... which can lead to iron deficiency and anemia. Low ...
(Date:8/20/2014)... Aug. 20, 2014 /CNW/ -  Issue ... can quickly become life threatening for some children.    ... 1.2 million Canadians have food allergies and this number may ... of children are estimated to have food allergies.  ... skin irritations and hives to breathing difficulties and loss of ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... Modern Mobility Aids, Inc. (the "Company"), headquartered in Nevada, ... the common stock of Lumigene Technologies Inc. ("Lumigene") and ... Lumigene is a private Canadian company ... and accurate detection of a number of specific pathogens ...
... Moran , an internationally renowned expert on evolution, will give the ... on Monday, March 5. The lecture, titled "Genome evolution in ... Auditorium, Room 1102A, Genomics Building . The talk will ... Entomology Building lobby. Both the talk and reception are ...
... Probing the largely unexplored question of what characteristics make ... by mimicking nature, a robotic fish can transform into ... of experiments, researchers from Polytechnic Institute of New York ... behavior, including learning how robots might someday steer fish ...
Cached Biology News:Leading evolutionary scientist to discuss how genome of bacteria has evolved 2What makes a robot fish attractive? (Hint: It's in the moves) 2
(Date:8/21/2014)... 2014 ... the addition of the  "Global Hormone Replacement ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,Hormone replacement ... a means of replacing hormones that are ... This type of therapy is usually initiated ...
(Date:8/21/2014)... N.Y. (PRWEB) August 21, 2014 The ... the first private college in the Mid-Hudson Region to ... will now begin accepting applications from qualified “high-technology” businesses ... “We are very pleased to have been selected for ... Governor Cuomo’s transformative initiative to stimulate economic development in ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
(Date:8/21/2014)... Pursuit Solutions ( http://www.pursuit-solutions.com ), a ... for Life Sciences sales and marketing organizations, announced ... Commercial Sales Models” by Peter Robinson, co-founder and ... examines some innovative models used to improve sales ... the pharmaceutical market. Robinson grades the industry on ...
Breaking Biology Technology:Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2
... , Using the Eppendorf Mastercycler gradient , ... Ulrich Genschel , Institute of General ... , , , , , ... isolation forms the basis for detailed , analyses at ...
... , , , , , ... Behrens, PhD, and Dietmar Kahle, PhD , ... Dept., Bernhard-Nocht-Str. 74, D-20359 Hamburg , ... Am Botanischen Garten, D-24118 Kiel , Barbara Behrens, ...
... Rapid Isolation of Plant RNA, Using the Eppendorf ... , , , , ... Planck Institut fr Zchtungsforschung, Carl-von-Linn , Weg 10, 50829 Cologne, ... , Barbro Patterson, Eppendorf ...
Cached Biology Technology:Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 2Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 3Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 4Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 5Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 2Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 3Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 4Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 5Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 6Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 7Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 8Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 9Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 10Simple and Rapid Isolation of Plant RNA, Using the Eppendorf Perfect RNA, Eukaryotic, Maxi Kit 2Simple and Rapid Isolation of Plant RNA, Using the Eppendorf Perfect RNA, Eukaryotic, Maxi Kit 3Simple and Rapid Isolation of Plant RNA, Using the Eppendorf Perfect RNA, Eukaryotic, Maxi Kit 4Simple and Rapid Isolation of Plant RNA, Using the Eppendorf Perfect RNA, Eukaryotic, Maxi Kit 5Simple and Rapid Isolation of Plant RNA, Using the Eppendorf Perfect RNA, Eukaryotic, Maxi Kit 6
poliovirus receptor-related 2 (herpesvirus entry mediator B), mRNA...
...
CREB-2 (H-290)...
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: