Navigation Links
Cellular landscaping: Predicting how, and how fast, cells will change
Date:11/1/2012

A research team at the National Institute of Standards and Technology (NIST) has developed a model* for making quantifiable predictions of how a group of cells will react and change in response to a given environment or stimulusand how quickly. The NIST model, in principle, makes it possible to assign reliable numbers to the complex evolution of a population of cells, a critical capability for efficient biomanufacturing as well as for the safety of stem cell-based therapies, among other applications.

The behavior and fate of cells are only partially determined by their DNA. A living cell reacts to both its internal and external environmentthe concentration of a particular protein inside itself or the chemistry of its surroundings, for exampleand those reactions are inherently probabilistic. You can't predict the future of any given cell with certainty.

This inherent uncertainty has consequences, according to NIST biochemist Anne Plant. "In the stem cell area in particular, there's a real safety and effectiveness issue because it's very hard to get 100 percent terminal differentiation of stem cells in a culture," she says. This could be problematic, because a therapist wishing to produce, say, heart muscle cells for a patient, might not want to introduce the wild card of undifferentiated stem cells. "Or effectiveness may be dependent on a mixture of cells at different stages of differentiation. One of the things that is impossible to predict at the moment is: if you waited longer, would the number of differentiated versus nondifferentiated cells change? Or if you were to just separate out the differentiated cells, does that really remove all the nondifferentiated cells? Or could some of them revert back?" says Plant.

The NIST experiments did not use stem cells, but rather fibroblasts, a common model cell for experiments. The team also used a standard tracking technique, modifying a gene of interestin this case, one that codes for a p
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. BioLife Solutions Products Now Used in More than 50 Clinical Trial-Stage Cellular Therapies
2. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
3. Division of labor offers insight into the evolution of multicellular life
4. Researchers study knee stress at tissue, cellular levels
5. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
6. BUSM study shows role of cellular protein in regulation of binge eating
7. Groundbreaking discovery of the cellular origin of cervical cancer
8. A non-invasive intracellular thermometer with fluorescent proteins has been created
9. Make or break for cellular tissues
10. Cellular secrets of plant fatty acid production understood
11. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular landscaping: Predicting how, and how fast, cells will change
(Date:9/19/2014)... Durante of dinosaurs a newly discovered hadrosaur ... dinosaur, named Rhinorex condrupus by paleontologists ... University, lived in what is now Utah approximately ... period. , Rhinorex, which translates roughly into "King ... of other Cretaceous hadrosaurs like Parasaurolophus and Edmontosaurus. ...
(Date:9/19/2014)... researchers from several Harvard University labs in collaboration ... aspiring researchers with the intellectual raw materials needed ... soft, flexible materials. , With the advent of ... in manufacturing technology, soft robotics is emerging as ... conventional rigid robot design, but working with pliable ...
(Date:9/19/2014)... the unique bioelectric signaling system of the electric fish, ... The OU researcher is working to understand how these ... used to map the world around them. Electric ... discharges a second throughout their lives. The energetic ... necessary for survival. , "There is evidence that electric ...
Breaking Biology News(10 mins):New hadrosaur noses into spotlight 2Soft robotics 'toolkit' features everything a robot-maker needs 2
... Company Anticipates Acquisition Could More Than Double its Current ... the Medical and Healthcare Industry, SAN JOSE, Calif., ... a leading biometric and security,solutions provider, announced today the ... Medical Systems (OTC: CHSY), a company listed in,the US ...
... The gigantic fossil claw of an 390 million-year-old sea scorpion, ... insects, crabs and the like were surprisingly larger than ... O. Erik Tetlie , postdoctoral associate in the Department of ... of the report online in Royal Society Biology Letters. The ...
... Newly launched nerve cells in a growing embryo must chart ... use to navigate have yet to surface. In a study published ... Salk Institute for Biological Studies have recovered a key signal that ... spinal cord and must find their way down the length of ...
Cached Biology News:Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 2Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 3Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network 4Salk scientists identify key nerve navigation pathway 2Salk scientists identify key nerve navigation pathway 3
(Date:9/20/2014)... (PRWEB) September 20, 2014 Entries are ... Prism Awards for Photonics Innovation . The international ... multi-billion dollar optics and photonics industry, and is sponsored ... photonics , and Photonics Media . , The ... versatility of photonics, said SPIE CEO Eugene Arthurs. , ...
(Date:9/20/2014)... HealthTronics, Inc. , a ... products and services, has signed a distribution agreement ... Corporation for its high precision laser technology. ... invasive, mobile, surgical technology—offering more choices for healthcare ... HealthTronics will make available Clinicon’s FDA-cleared SureLase™ CO2 ...
(Date:9/20/2014)... September 20, 2014 MediVet America ... perform a groundbreaking surgery at the specialized Wolvega Horse ... superficial digital flexor tendon was ruptured 90% and her ... injury is a death sentence for a horse. , ... stem cell treatments . This revolutionary regenerative option ...
(Date:9/19/2014)... Sept. 19, 2014  InterMune, Inc. (Nasdaq: ... Memorandum of Understanding to settle the litigation in the ... Plan of Merger dated as of August 22, 2014, ... Inc.  As one term of the Memorandum of Understanding, ... forth in the attached exhibit reflecting the amendment to ...
Breaking Biology Technology:Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19
... 25 Scimitar Equity, LLC issues a ... VOQP), entitled,"Creating Value; Turnaround Leverages Product Opportunities ... review is available at website: http://www.scimitarequity.com ... Jersey-based biotechnology company,dedicated to becoming a recognized ...
... 25 Mymetics,Corporation (OTC: MYMX), will be holding an ... PM New York Time to update all shareholders,on the ... Form 10-Q and to,address recent press articles., You ... at +1-866-591-4361 PIN 815,726 and from Europe at +41-800-329-326 ...
... 23 Eisai Corporation of,North America and its ... Food and Drug Administration (FDA) has approved a ... prevention of,chemotherapy-induced nausea and vomiting (CINV). ALOXI Capsules ... prevention of acute nausea and,vomiting following initial and ...
Cached Biology Technology:VioQuest Pharmaceuticals, Inc Q2/08 Review Issued by Scimitar Equity, LLC 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 2FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting 3