Navigation Links
Cellular gates for sodium and calcium controlled by common element of ancient origin
Date:7/1/2014

a graduate student in Yue's laboratory, took up the question. "We thought that the conflicting results for sodium channels might be related to difficulties in existing methods to control the calcium concentrations that might affect these channels," Ben-Johny says.

Looking for a new way to approach the problem, Yue's team bound calcium ions in molecular "cages" that could be opened with a flash of light. This enabled them to "smuggle" calcium ions into cells and see what happened to sodium channels when the calcium concentration changed abruptly. They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

The implications of a common control element in sodium and calcium channels are vast, Yue says, including unified understanding of conditions that spring from defects in the calcium control of these channels. In addition, he says, "Researchers have long sought drugs that modulate sodium and calcium channels in new ways. Targeting the common control element offers a new frontier for developing next-generation pharmaceuticals."


'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Salk scientists open new window into how cancers override cellular growth controls
2. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
3. Cellular secrets of plant fatty acid production understood
4. Make or break for cellular tissues
5. A non-invasive intracellular thermometer with fluorescent proteins has been created
6. Groundbreaking discovery of the cellular origin of cervical cancer
7. BUSM study shows role of cellular protein in regulation of binge eating
8. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
9. Researchers study knee stress at tissue, cellular levels
10. Division of labor offers insight into the evolution of multicellular life
11. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular gates for sodium and calcium controlled by common element of ancient origin
(Date:8/27/2014)... 400 million years ago a group of fish began exploring ... and mammals. But just how these ancient fish used their ... evolutionary processes were at play remain scientific mysteries. , ... , turned to a living fish, called Polypterus , ... attempted to walk out of the water. Polypterus ...
(Date:8/27/2014)... brain of mice, scientists have altered the emotional ... Howard Hughes Medical Institute investigator Susumu Tonegawa at ... the connections between the part of the brain ... the part of the brain that stores the ... , Altering those connections can transform a negative ...
(Date:8/27/2014)... greatest risk to Europe based upon a proxy for ... using a ,big data, approach to scientific research. , ... Global Health ranked the top 100 pathogens affecting humans ... system which, they believe, will help governments across the ... infectious diseases, including as a result of climate change, ...
Breaking Biology News(10 mins):Walking fish reveal how our ancestors evolved onto land 2Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... 12, 2009) HOBOKEN, NJ According to the ... U.S. population will have hemorrhoids by the age of ... hemorrhoids is over-the-counter remedies, most patients do not report ... they are in severe distress, including bleeding. A ...
... A growing number of scientists are merging methods and results ... says a team of researchers in a recent issue of ... focused on new data, however, researchers who want to analyze ... institutional support, the authors say. In a commentary piece in ...
... - Mango. If you know little about this fruit, understand ... and breast cancer cells in the lab. That,s ... scientists, who examined the five varieties most common in the ... the mango is an ancient fruit heavily consumed in many ...
Cached Biology News:Study shows pine bark naturally relieves symptoms of acute hemorrhoids 2Study shows pine bark naturally relieves symptoms of acute hemorrhoids 3Biologists merge methods, results from different disciplines to find new meaning in old data 2Biologists merge methods, results from different disciplines to find new meaning in old data 3Mango effective in preventing, stopping certain colon, breast cancer cells 2
(Date:8/27/2014)... 2014 Tris Pharma, a specialty pharmaceutical company ... that it has been selected as an award winner ... 2014 Awards for Excellence competition in the Business ... of judges from SCORE (Counselors to America,s Small Business) ... honored at a gala event to be held on ...
(Date:8/27/2014)... City, OR (PRWEB) August 27, 2014 ... stands to reason that the next beverage craze is ... Technology announced today that formulators can use Stress Relief ... ingredient used in the making of a beverage, including ... release for stress-generated energy, channeling that power into rapid ...
(Date:8/27/2014)... Cranford, NJ (PRWEB) August 27, 2014 ... and services – has once again shown superiority when ... trial sponsor by completing the ePRO portion of their ... results. The Japan-based pharma chose WriteResult’s digital writing ... IBS trials – the first to complete drew data ...
(Date:8/26/2014)... LOS ANGELES , Aug. 26, 2014  NeuroSigma, ... sciences company established to develop bioelectronic technologies, today announced ... S-1 with the U.S. Securities and Exchange Commission relating ... stock. The number of shares to be offered and ... yet been determined. Jefferies LLC will act ...
Breaking Biology Technology:Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 4A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2
... Colo., Sept. 24 InVitria,( http://www.InVitria.com ) ... "Optimizing Cell Culture Development" Conference on,September 15-16 ... recent,results optimizing cell culture media using its ... http://www.healthtech.com/ocb/overview.aspx?c=562 ), In a presentation of ...
... use of AHCC for immune enhancement during cold & ... new paper published in,Nutrition Reviews (Vol. 66(9):526-531) by Dr. ... Drexel University, has shown,how AHCC impacts the immune response ... review analyzed outcomes from in vivo studies evaluating,the effect ...
... Calif., Sept. 24 NeurogesX, Inc.,(Nasdaq: NGSX ... novel pain management therapies, announced today that it,has ... (EMEA) Day 120,questions to support the Marketing Authorization ... NeurogesX, MAA for NGX-4010 in peripheral neuropathic pain ...
Cached Biology Technology:InVitria Touts Product Advantages at Cambridge's Cell Culture Conference 2Research Shows How AHCC(R) May Help Fight Flu and Other Infectious Agents 2NeurogesX Responds to EMEA's Day 120 Questions 2NeurogesX Responds to EMEA's Day 120 Questions 3
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z35,347-7) or contact ...
... Freedom EVO384R are fast multi-channel pipetting platforms ... different sizes, with a multi-channel head and ... time saving, with true parallel processing of ... your assays with the Freedom EVOware program. ...
... EVO384R are fast multi-channel pipetting platforms consisting ... sizes, with a multi-channel head and a ... saving, with true parallel processing of sample ... assays with the Freedom EVOware program. ...
Prepared by multi-temperature ethanol fractionation with extensive charcoal treatment and dialysis.• Assay: ≥ 95 % (HPCE)• pH ~5.2 (10 mg/mL in 0.15 M NaCl)...
Biology Products: