Navigation Links
Cellular gates for sodium and calcium controlled by common element of ancient origin
Date:7/1/2014

Researchers at Johns Hopkins have spotted a strong family trait in two distant relatives: The channels that permit entry of sodium and calcium ions into cells turn out to share similar means for regulating ion intake, they say. Both types of channels are critical to life. Having the right concentrations of sodium and calcium ions in cells enables healthy brain communication, heart contraction and many other processes. The new evidence is likely to aid development of drugs for channel-linked diseases ranging from epilepsy to heart ailments to muscle weakness.

"This discovery was long in coming," says David Yue, M.D., Ph.D., a professor in the Johns Hopkins University School of Medicine's Department of Biomedical Engineering. His team's report, which appears in the June 19 issue of the journal Cell, had its genesis in the 1990s with another group's observation that sodium and calcium channels bear a striking resemblance in a small portion of an otherwise very different structure. "It looked like this 'resemblance element' might be a molecular time capsule derived from a primeval ion channel thought to have birthed distinct sodium and calcium channels a billion years ago," Yue says.

For calcium channels, Yue's and other research groups found that the resemblance element supports an important function, preventing the channel from opening when the cellular calcium level gets high. This prevents too much calcium from building up within cells, much like a thermostat controls household temperatures. This calcium control requires a calcium-sensing molecule called calmodulin, which binds to channels within the resemblance element.

The picture for sodium channels, however, was muddier, with different researchers reporting conflicting findings about whether calmodulin and the resemblance element prevent the opening of sodium channels; perhaps the time capsule was damaged over the millenia or was never there.

Manu Ben-Johny,
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Salk scientists open new window into how cancers override cellular growth controls
2. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
3. Cellular secrets of plant fatty acid production understood
4. Make or break for cellular tissues
5. A non-invasive intracellular thermometer with fluorescent proteins has been created
6. Groundbreaking discovery of the cellular origin of cervical cancer
7. BUSM study shows role of cellular protein in regulation of binge eating
8. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
9. Researchers study knee stress at tissue, cellular levels
10. Division of labor offers insight into the evolution of multicellular life
11. Newly demonstrated capabilities of low-powered nanotweezers may benefit cellular-level studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular gates for sodium and calcium controlled by common element of ancient origin
(Date:5/14/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ... Sensors Market in Smart Mobile Devices " report ... 2014 was a watershed year for fingerprint sensors in ... Pay,. Apple gave fingerprint sensors a raison d,etre in ... sensors are a must-have feature in flagship smartphones. ...
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, a ... start of a new Phase III double blind, randomized, ... novel formulation, CM-AT, on all children ages 3-8 with ... FDA Phase III double blinded clinical trial for CM-AT ... levels of the digestive enzyme chymotrypsin. This new trial ...
(Date:5/6/2015)... 2015 LifeBEAM, a developer of bio-sensing technology, ... today that they will expand their partnership in bio-sensing ... cycling helmet and the first joint project between the ... in order to give cyclists more style choices and ... and Lazer announced their plan to release a new ...
Breaking Biology News(10 mins):Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... HOLE, MADr. Bruce J. Peterson, a senior scholar at ... the Association for the Sciences of Limnology and Oceanography ... Achievement Award. The award honors the career achievements of ... importance and long-term influence. Dr. Peterson is being honored ...
... breakthrough at the University of Huddersfield has received extra stimulus ... major conference in Australia. Mari L. Uchimoto, from Montana, ... member of its Forensic Genetics Research Group and supervised by ... a team working on the use of microRNA analysis in ...
... the Norwegian University of Science and Technology in Trondheim have ... of winter conditions for fish in streams and rivers in ... journal BioScience . It is well known that ... in streams and rivers. It is reasonable to assume that ...
Cached Biology News:MBL scientist Bruce Peterson wins ASLO Lifetime Achievement Award 2MBL scientist Bruce Peterson wins ASLO Lifetime Achievement Award 3Mari's presentation tops ANZFSS International Symposium 2Extreme winters impact fish negatively 2
(Date:5/28/2015)... MIAMI BEACH, Fla. , May 28, 2015 /PRNewswire/ ... data supporting the anti-cancer potential of its growth hormone-releasing ... presentation at the 2015 ASCO Annual Meeting. The ... the target for Biscayne,s anti-cancer GHRH blockers, is present ... receptor status. These findings suggest that GHRH antagonists could ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
(Date:5/28/2015)... Clinerion, an eClinical technology ... the Alliance for Clinical Research Excellence and ... operating in the public interest and dedicated ... quality, safety, integrity and operational effectiveness in ... pleased to announce their partnership for accelerating ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 The Academy of ... join in celebrating National Model Aviation Day. The third annual ... was created to celebrate the model aviation hobby nation-wide and ... all of its approximately 2,350 chartered clubs to celebrate the ... event in their communities. There will also be a local ...
Breaking Biology Technology:Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Clinerion and ACRES Partner on Patient Recruitment and Risk-Based Quality Management 2Clinerion and ACRES Partner on Patient Recruitment and Risk-Based Quality Management 3Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3
... aid the fight of the deadly outbreak of E. ... at the University Medical Centre Hamburg-Eppendorf have released an ... data previously released and submitted to NCBI in the ... assembled using the latest ion semiconductor sequencing technology, there ...
...  Grifols, S.A. (NASDAQ: GRFS ) ... based in Barcelona, Spain today announced that on ... Talecris Biotherapeutics Holdings Corp. ("Talecris").  In partial consideration ... shares that trade in the U.S. as Grifols ...
... LifeVantage Corporation (OTCBB: LFVN), the maker ... the reduction of oxidative stress by the synergistic ... peer-reviewed review article involving Protandim® was published in ... (Logo:   http://photos.prnewswire.com/prnh/20090930/LIFEVANTAGELOGO ) ...
Cached Biology Technology:Further Analysis on Improved Genome Assembly Indicates the Outbreak E. coli has Complex Genetics With Resistance to at Least Eight Antibiotics 2Further Analysis on Improved Genome Assembly Indicates the Outbreak E. coli has Complex Genetics With Resistance to at Least Eight Antibiotics 3Grifols Announces the Completion of its Acquisition of Talecris and the Listing of its ADSs on NASDAQ 2LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 2LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 3LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 4LifeVantage's Nrf2 Activator Reviewed for Tumor Prevention and Suppression in New Peer-Reviewed Article 5