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Cellular channels vital for hearing identified
Date:7/18/2013

ning why hearing loss is gradual and not immediate. "TMC2 can compensate for loss of function of TMC1, but not completely," Holt says.

  • The two proteins can create channel structures either singly or combined in groups, suggesting they may help make different hair cells sensitive to different pitch ranges. "There are gradients of expression of these two proteins, which we think are involved in tuning of the sensory cell," says Holt.

    Based on the initial genetic discovery in 2011, a gene therapy study is now underway in mice to see whether reintroducing TMC1 and/or TMC2 genes to the inner ear could restore hearing. The team is looking for electrical signals in the 8th cranial nerveindicating that the brain is being signaledand more importantly whether the animals respond to sound.


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  • Contact: Meghan Weber
    meghan.weber@childrens.harvard.edu
    617-919-3656
    Boston Children's Hospital
    Source:Eurekalert

    Page: 1 2

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