Navigation Links
Cell's split personality is a major discovery into neurological diseases
Date:5/7/2009

Researchers at the Universit de Montreal (UdeM) and the Montreal Neurological Institute (MNI), McGill University have discovered that cells which normally support nerve cell (neuron) survival also play an active and major role in the death of neurons in the eye. The findings, published this week in The Journal of Neuroscience, may lead to more streamlined therapies for a variety of acute and chronic neurological disorders, including glaucoma and retinal artery occlusion.

In many neurodegenerative diseases, a main factor that kills neurons is excessive levels of glutamate, the most abundant excitatory neurotransmitter in many regions of the central nervous system (CNS). Diseases that occur as a result of high glutamate levels include hypoxicischemic brain injury (stroke), trauma, seizures, various forms of dementia and neurodegeneration. For years, the main explanation for the toxic effects of glutamate is that it overexcites neuronal cells via activation of glutamate receptors and thereby kills them.

"The most interesting aspect of our study and the reason we are so excited is that the pathway leading to glutamate-induced nerve cell death involves another vital player namely, glial cells," says Dr. Adriana Di Polo, neuroscientist at the UdeM. "Through careful experimentation we now know that glutamate activates signaling pathways in glial cells that then lead to neuronal death."

Glial cells are the most abundant cell type in the nervous system and are traditionally thought of as 'partner' cells to nerve cells providing support, nutrients and an optimal environment. However, this study indicates that glial cells also have a more sinister side that allows them to induce or exacerbate neuronal death in pathological conditions.

"Neuronal cell death induced by glutamate is a key step in a large number of injury and disease settings and this study is important because it provides a road-map for the cellular and molecu
'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... of two additional coral communities showing signs of damage from ... the 2010 spill in the Gulf of Mexico. The discovery ... of biology at Penn State University. A paper describing this ... the Gulf of Mexico will be published during the last ... the journal Proceedings of the National Academy of Sciences ...
(Date:7/28/2014)... Millions of people in the United States have a ... It can be painful and may even require surgery ... skeletal muscle wasting and, in turn, limb amputation. , ... Houston (UTHealth) Medical School, scientists tested a non-surgical preventative ... it was associated with increased blood circulation. Their ...
(Date:7/28/2014)... Yale School of Medicine have pinpointed a mechanism in part ... in the blood, linking it to both type 1 and ... 28 issue of Proceedings of the National Academies of ... enzyme located in a part of the hypothalamus known ... in motion that control glucose levels in the blood," said ...
Breaking Biology News(10 mins):Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Glucose 'control switch' in the brain key to both types of diabetes 2
... rules of school are simple: it is all about watching ... what they do. Researchers at the mathematics department at Uppsala ... fish apply similar rules when traveling in small shoals. ... are seen in the collective motion of fish schools and ...
... CYBERSECURITY -- Foiling exfiltration . . . Computer ... being developed by a team led by Justin Beaver of ... months, attackers who breach a system,s defense have a distinct ... a window into potentially sensitive data and their true identity ...
... HOUSTON, Nov. 8, 2011 Thanks to almost $1 million ... of Texas (CPRIT), the University of Houston (UH) will soon ... grant will be applied toward the purchase and installation of ... and cancer progression. With access to the latest in imaging ...
Cached Biology News:Fish follow the rules to school 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, November 2011 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, November 2011 3Story tips from the US Department of Energy's Oak Ridge National Laboratory, November 2011 4UH receives $990K grant to enhance cancer research facilities 2
(Date:7/28/2014)... COLLEGE STATION, Texas , July 28, 2014   ... will be a 177-key, 4-star boutique hotel in the heart of ... , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... first hotel within ATLAS , The ... of standard rooms and suites, a sleek restaurant and bar, a ...
(Date:7/25/2014)... (PRWEB) July 26, 2014 "Ischemic ... H2, 2014" provides data on the Ischemic Stroke ... provides elemental information and data relating to the ... , View full global Ischemic Stroke Research Report ... an overview of the trial numbers and their ...
(Date:7/25/2014)... DUBLIN , July 25, 2014 ... of the "Global Metabolomics Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics ... metabolites. Metabolomics has become a new experimental technique ... and the environmental sciences. Metabolites are small molecules ...
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William ... " The World's Most Influential Scientific Minds ." , ... who were identified by analyzing citation data over the ... highest-impact work (2002-2012 and 2012-2013). The two were selected ... . , "This recognition is a great honor for ...
Breaking Biology Technology:Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4
... Abstracts Accepted for Presentation at ASCO, SOUTH SAN FRANCISCO, ... hold an investor and analyst briefing in,conjunction with the 44th ... 6:00 p.m. to 8:00 p.m. CT on Monday, June 2,2008., ... and Chief Executive Officer -- Michael M. Morrissey, PhD, ...
... the launch of a new collaborative website initially focusing ... The WikiProfessional technology underlying the site has been developed ... Centrals open access journal Genome Biology, WikiProteins provides a ... , The article is written by Barend Mons of ...
... miniaturization, carbon nanotubes which are about 100,000 times ... and very useful properties have become the choice ... and mechanical devices. But it is precisely their infinitesimal ... that make it difficult for scientists to manipulate nanotubes. ...
Cached Biology Technology:REMINDER: Exelixis Will Webcast Its June 2 Investor and Analyst Briefing at ASCO 2REMINDER: Exelixis Will Webcast Its June 2 Investor and Analyst Briefing at ASCO 3REMINDER: Exelixis Will Webcast Its June 2 Investor and Analyst Briefing at ASCO 4Large-scale community protein annotation -- WikiProteins 2Weizmann Institute scientists create new nanotube structures 2
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
fli-1...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: