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Cells send dirty laundry home to mom
Date:2/1/2010

e which controls the rate of ageing, called SIR2, is needed for these cables to form properly. Previous research has shown that changing the SIR2 gene can markedly extend the life-span of an organism.

Longer life

"Increased SIR2 activity means a longer life, whereas a damaged SIR2 gene accelerates ageing," says Nystrm. "This has been demonstrated in studies of yeast, worms, flies and fish, and may also be the case in mammals."

Future treatment

This knowledge of how age-damaged proteins are transported from daughter cell to mother cell could eventually be used in the treatment of age-related diseases caused by protein toxicity in humans, but Nystrm says that it is too early to say how.

The first step

"The first step is to study whether this transportation of damaged proteins also occurs in the cells of mammals, including humans, for example in the formation of sex sells and stem cells."


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Contact: Thomas Nystrm
thomas.nystrom@cmb.gu.se
46-317-862-582
University of Gothenburg
Source:Eurekalert  

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