Navigation Links
Cells must use their brakes moderately for effective speed control
Date:5/15/2013

How cells regulate their own function by "accelerating and braking" is important basic knowledge when new intelligent medicines are being developed, or when plant cells are tweaked to produce more bioenergy. In a study published by Nature Communications 14 May, researchers at Uppsala and Ume universities show a model of how cells' regulatory systems work.

All living cells have a regulatory system similar to what can be found in today's smartphones. Just like our phones process a large amount of information that we feed them, cells continuously process information about their outer and inner environment. Inside the cells, information is sent and processed via a large network of interactions between signalling molecules.

In electronic circuits it is common with negative feedback, inhibiting functions, to make signals clearer and to reduce noise that can obscure important information. Cells also use this technique for reducing unwanted noise. Almost half of all signalling molecules that regulate which genes should be on or off, regulate their own genetic expression through biochemical reactions acting as inhibitors.

"If the number of signalling molecules is more than necessary, they shut down their own production for a short while, to later resume it. The difference between feedback in electronic systems and biological systems is that biological systems are much more imprecise and slow", explains Andreas Grnlund, lead author, currently active at Ume University.

Together with professors Per Ltstedt and Johan Elf, both at Uppsala University, he has used new data and mathematical models to calculate how long the molecules must remain in their binding sites to make the feedback exactly strong enough to reduce noise as much as possible.

The calculations showed that the molecules ideally should bind significantly weaker than previously believed, a characteristic that turned out to correspond well to the binding strength found in global regulatory molecules in E. coli bacteria.

"A car driver needs to know when and how hard to press the brake in different situations and which way to turn the steering wheel in a left turn. In the same way, we need to increase our understanding of regulatory systems in cells to be able to develop new intelligent medicines when the regulation system doesn't work or to be able to control plant cells to produce green energy through more efficient production of bio mass", says Johan Elf.


'/>"/>

Contact: Andreas Grönlund
andreas.gronlund@umu.se
090-786-6787
Uppsala University
Source:Eurekalert

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology: