Navigation Links
Cells' 'molecular muscles' help them sense and respond to their environments
Date:10/20/2013

Johns Hopkins researchers used suction to learn that individual "molecular muscles" within cells respond to different types of force, a finding that may explain how cells "feel" the environment and appropriately adapt their shapes and activities.

A summary of the discovery, published online Oct. 20 in the journal Nature Materials, specifically sheds light on how forces outside of cells are translated into internal signals.

A computer model the researchers developed, they add, also lets them predict what a cell will do in response to altered levels of those "muscles," a common occurrence in a variety of cancers.

"We can now begin explaining what goes on in various diseases because we understand the fundamental mechanisms behind how cells experience different forces and respond to them," says Douglas Robinson, Ph.D., professor of cell biology at the Johns Hopkins University School of Medicine.

"For the first time," he adds, "we are able to explain what a cell can do through the individual workings of different proteins, and because all cells use information about the forces in their environments to direct decisions about migration, division and cell fate, this work has implications for a whole host of cellular disorders including cancer metastasis and neurodegeneration."

Life as a cell, Robinson notes, is not so easy. For example, most cells are constantly pummeled by water molecules moving at speeds around 1,100 mph (almost 2,000 kph and roughly six times the speed of Category 5 hurricane winds). Red blood cells tumble through blood vessels and squeeze through tiny capillaries to bring oxygen to every part of the body. And bone cells feel the weight of an organism in a way that other cells don't.

"Cells, like our bodies, have a sort of skin through which they sense their environments," explains Robinson. "The hardness of their surroundings, various pressures, pushing and pulling, all of tho
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. When cells eat their own power plants; Pitt scientists solve mystery of cellular process
2. New research shows how heart cells communicate to regulate heart activity
3. Specific sugar molecule causes growth of cancer cells
4. UAlberta medical researchers discover how immune system kills healthy cells
5. Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
6. Youthful stem cells from bone can heal the heart, Temple scientists report
7. Research identifies how mouth cells resist Candida infection
8. Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
9. UC Davis team spikes stem cells to generate myelin
10. Why are some cells more cancer prone?
11. Harvard Stem Cell researchers create cells that line blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cells' 'molecular muscles' help them sense and respond to their environments
(Date:9/2/2014)... New research suggests that professional baseball pitchers with poor ... days in a single season because of injury than are ... back and pelvis. , In the study, 347 pitchers were ... tilt in their pelvis as they raised a leg to ... miss at least 30 days cumulative, not consecutive ...
(Date:9/2/2014)... issue of The FASEB Journal , ... the leading cause of blindness in adults, diabetic ... advance involves quantifying the early molecular changes caused ... Using new probes developed by scientists, they were ... diabetic retinopathy. , "My goal is to establish ...
(Date:9/2/2014)... 2, 2014 Best-selling author Sam Kean stops by ... Megalodon, the 50-foot super shark that, despite what "Shark ... Learn all about it at http://youtu.be/KhFygIoW_MA . , ... of Madness, Love and the History of the World ... the Reactions treatment in a 10-episode video series produced ...
Breaking Biology News(10 mins):In pro baseball pitchers, weak core linked to more missed days 2In pro baseball pitchers, weak core linked to more missed days 3Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2
... The apparently random self-assembly of molecular threads into the ... frantic than previously thought, Michigan State University scientists say. ... the nature of some diseases. How proteins spontaneously ... wide variety of functional or malfunctioning three-dimensional ...
... A phylogenetic analysis can take a long time to ... efficiently and effectively. The National Institute for Mathematical and ... focusing on high performance computing (HPC) for phylogenetics. ... to use TeraGrid, the CIPRES Portal, the iPlant Discovery ...
... The American Physical Society (APS) announces a new public ... public libraries in the United States full use of ... back to the first issue in 1893, a collection ... provide this access at no cost to participating public ...
Cached Biology News:Scientists post lower speed limit for cell-signaling protein assembly 2
(Date:9/2/2014)... be used for detailed studies of what happens on ... pharmaceuticals research, among other applications. A group of researchers ... artificial cell membranes form across a large number of ... between the interior of a cell and its surroundings ... a surface layer that holds the cell together and ...
(Date:9/2/2014)... 2014 Persistence Market Research ( ... Pharmaceutical, Biopharma and Life Sciences: North America ... membrane technology market for pharmaceutical, biopharma and life sciences is ... expected to grow at a CAGR of 9.1% from ... USD 10,886.0 million in 2019. Browse the ...
(Date:9/2/2014)... Myriant Corporation, a global renewable chemicals ... agreement with Azelis Group, a specialty chemicals distribution ... in the Nordics, Benelux, France, Iberia, Italy, the ... industrial and base chemicals markets. , “As a ... chemical portfolio with extensive distribution networks providing Myriant ...
(Date:9/2/2014)... Sept. 2, 2014  Xencor, Inc. (NASDAQ: ... engineered monoclonal antibodies for the treatment of autoimmune ... announced the appointment of Debra Zack , ... appointment of Lloyd Rowland , senior vice ... "Debra,s expertise in biologics clinical development ...
Breaking Biology Technology:Nano-forests to reveal secrets of cells 2Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 2Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 3Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 4Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 5Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3
... release is available in German . ... with microelectronic components gradually being replaced by nanoelectronic ... the present stage the most commonly used material ... further miniaturization and technological progress. New electronic materials ...
... Rosei of the INRS Energy Materials Telecommunications Center has ... Friedrich Wilhelm Bessel Research Award given by the Alexander ... awards annually to young, high level researchers around the ... caliber and scope of his research in the field ...
... PharmAthene, Inc. (NYSE Amex: PIP ), a ... threats, today reported financial and operational results for the ... For the third quarter of 2010, PharmAthene ... in the same period of 2009.  For the nine ...
Cached Biology Technology:Step by step toward tomorrow's nanomaterial 2INRS professor Federico Rosei receives a 2010 Friedrich Wilhelm Bessel Research Award 2PharmAthene Reports Third Quarter 2010 Financial and Operational Results 2PharmAthene Reports Third Quarter 2010 Financial and Operational Results 3PharmAthene Reports Third Quarter 2010 Financial and Operational Results 4PharmAthene Reports Third Quarter 2010 Financial and Operational Results 5PharmAthene Reports Third Quarter 2010 Financial and Operational Results 6PharmAthene Reports Third Quarter 2010 Financial and Operational Results 7
Goat polyclonal to Factor VIII, prediluted ( Abpromise for all tested applications). Antigen: Full length native protein (purified) (Human): Factor VIII from blood. Entrez GeneID: 2157 Sw...
Anti-Bcl-G (CT) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
Affinity Purified Rabbit Anti-mouse sRANKL Biotinylated Polyclonal Antibody...
Polyclonal antiserum raised against conjugated L-isoleucine. Available as antiserum. Amino Acid Antibodies...
Biology Products: