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Cells lining milk ducts hold key to spread of common form of breast cancer
Date:5/5/2008

BOSTON--When a form of cancer that begins in the milk ducts of the breast invades neighboring tissue to spread to other parts of the body, the cause lies not in the tumor cells themselves but in a group of abnormal surrounding cells that cause the walls of the duct to deteriorate like a rusty pipe, according to a new study led by Dana-Farber Cancer Institute researchers.

The discovery, reported in the May 6 issue of Cancer Cell, may lead to screening tests to determine whether the disease -- known as ductal carcinoma in situ, or DCIS -- is likely to spread beyond the ducts, based on genetic abnormalities in cells in the ducts' lining. And it sets the stage for treatments that, by targeting these abnormalities, shore up the duct walls and keep the cancer contained.

"Women whose DCIS has invaded the ducts are known to have a greater chance of metastasis, or spreading disease. But it hasn't been clear what causes the transition from a localized cancer to invasive disease," according to the study's senior author, Kornelia Polyak, MD, PhD, of Dana-Farber. "This study demonstrates that in DCIS of the breast, and potentially in other cancers that originate in duct tissues, the answer may lie in the tumor's microenvironment -- the cells and tissue that surround the cancer."

DCIS is expected to be diagnosed in nearly 53,000 women in the United States this year. When detected and surgically removed before it has a chance to spread, the disease is nearly always curable. It isn't known how many of these cancers would become invasive breast cancer if they weren't treated, but studies suggest that most of them eventually would.

Researchers initially thought that DCIS might become invasive as a result of genetic changes in the cancer cells. When they surveyed gene activity in immobile DCIS cells and in those that had spread, however, they found no significant differences. That led them to consider the cell's microenvironment.

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Contact: Robbin Ray
robbin_ray@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

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