Navigation Links
Cells 'flock' to heal wounds
Date:1/24/2013

ed us that we needed a different way to start to think about the problem."

The body marshals an astounding array of forces to heal wounds, Levine said. Many have to do with cell biology, the internal and external signals that tell a cell when to move, when to stop, when to split and when to die. His team's intent was to focus first on the cell's physical interactions with its neighbors and study what happened if all those complicating factors are eliminated from the simulations.

"We try to unravel what is physics and what is biology," Levine said. "We want to know which parts of the phenomenon don't require sophisticated signaling networks."

In the physics approach to cell motility, he said, "the first thing to do is see how far we can get if we assume that all the cells are following the same rules. Then the only thing that's creating the dynamics of the system is that they're interacting with each other. This is the type of problem that physicists have studied before, usually in nonbiological contexts."

In the Harvard experiment, he said, "They had taken a millimeter-sized tissue that was spreading and showed it wasn't just cells on the end that were pulling on the tissue while the others were spectators." But that work didn't explain how cells in the center of the tissue knew the direction of the edge.

Levine's team looked to the skies for inspiration. "Birds look around and decide which way all their neighbors are flying," Levine said. "The idea that they would move as independent birds but also coordinate is where the idea of flocking came from. This way of thinking hadn't been applied to epithelial tissue motility in wound healing."

What cells "see" are their sticky neighbors, which pull and tug them as they move on lamellipodia, thin sheets that serve as "feet" powered by actin filaments that act something like the treads on a tank. The overlapping lamellipodia of adjacent cells influence each other. "The
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Retrovirus in the human genome is active in pluripotent stem cells
2. Researchers show how cells DNA repair machinery can destroy viruses
3. Enzyme helps cancer cells avoid genetic instability
4. Mature T cells can switch function to better tackle infection
5. Quadruple helix DNA discovered in human cells
6. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
7. Using snail teeth to improve solar cells and batteries
8. Scientists seek out cancer cells hiding from treatment
9. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
10. 3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
11. After decades of research, scientists unlock how insulin interacts with cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
(Date:7/25/2014)... Spina bifda (SB) is a complex congenital central ... incomplete closing of the neural tubes during the ... spasticity, urinary and fecal incontinence and neurocognitive retardation. ... their quality of life. Researchers at Ankara Physical ... investigate the functional performance in children with SB, ...
(Date:7/25/2014)... The routine use of a molecular testing panel ... performing the correct initial surgery for patients with ... University of Pittsburgh Cancer Institute (UPCI), partner with ... Multidisciplinary Thyroid Center and other diagnostic testing agencies, ... initial surgery by 30 percent, according to the ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3
... Rocky Mountains and Great Plains, have been decimated in ... spread by fleas. Plague outbreaks periodically sweep through ... virtually the entire population within months. Other prairie dogs ... is wiped out when the disease returns. This ...
... the sugar fructose, very common in the Western diet, to ... the cancer to grow more quickly, a study by researchers ... it,s widely known that cancers use glucose, a simple sugar, ... link has been shown between fructose and cancer proliferation, said ...
... Arizona ecologist plans to involve Tucson neighborhoods in a ... ecology designs ways for the natural world to exist ... biodiversity. "The threat to biodiversity is much, much, ... director of UA,s Tumamoc: People & Habitats and of ...
Cached Biology News:Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 2Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 3Carnivorous mice spread deadly plague in prairie dog towns, Stanford study finds 4Pancreatic cancers use fructose, common in the Western diet, to fuel their growth 2Pancreatic cancers use fructose, common in the Western diet, to fuel their growth 3Reconciliation ecology: The fun way to adapt to climate change 2Reconciliation ecology: The fun way to adapt to climate change 3
(Date:7/25/2014)... New York (PRWEB) July 25, 2014 ... Market Research, "Biological Drugs Market - Global Industry Analysis, ... the global biological drugs market is estimated at USD ... at a CAGR of 10.1% from 2014 to 2020, ... in 2020. , The biological drugs market is witnessing ...
(Date:7/25/2014)... PA (PRWEB) July 25, 2014 The ... Call for Topics for Conferee Networking. These two-hour sessions ... interests to meet and resolve problems, discuss new techniques, ... The deadline to submit a topic for consideration is ... pittcon.org . The Conferee Networking committee will review ...
(Date:7/25/2014)... Israel , July 25, 2014  Galmed Pharmaceuticals ... biopharmaceutical company focused on the development and commercialization of ... diseases and cholesterol gallstones, today announced financial results for ... Half 2014 Financial Summary: , Reported cash and ... compared with $137,000 at December 31, 2013.  , ...
(Date:7/25/2014)... 25, 2014 At the request of ... a 60-day extension for the public comment period (Docket ... for Model Aircraft established by Congress as part of ... 60-day extension establishes the new deadline for comments as ... of Transportation/FAA notice published in the Federal Register on ...
Breaking Biology Technology:Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2
... Clinical Stage Product Portfolio -, ANN ... today announced that it is has completed ... commercialize products under AstraZeneca,s IP and,know-how regarding ... combination with,estrogen and progestin to treat endometriosis. ...
... IOMI ) today announced that Stanley C. Erck, ... the 10th Annual BIO,CEO & Investor Conference in New ... begin at 2 p.m. Eastern Time in the in ... give an update on corporate and clinical milestones and,detail ...
... Arena Pharmaceuticals, Inc.,(Nasdaq: ARNA ) announced today that ... & Investor Conference on February 12, 2008 at 9:30 ... Hotel in New York,City. David A. Walsey, Arena,s Director ... the company, including its clinical,development and discovery programs., ...
Cached Biology Technology:Meditrina Pharmaceuticals, Inc. Announces Exclusive Global License Agreement With AstraZeneca 2Meditrina Pharmaceuticals, Inc. Announces Exclusive Global License Agreement With AstraZeneca 3Iomai CEO to Speak at BIO CEO & Investor Forum on Feb. 12 2Arena Pharmaceuticals to Present at the BIO CEO & Investor Conference 2Arena Pharmaceuticals to Present at the BIO CEO & Investor Conference 3
Mouse monoclonal [1.T.4] to WAVE 1 ( Abpromise for all tested applications). Antigen: His6 fusion protein corresponding to full-length rat WAVE1. Entrez Gene ID: 8936...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
...
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
Biology Products: