Navigation Links
Cells do talk to one another, but the question remains how
Date:5/31/2011

ding to create engineered tissues that mimic the human liver.

The liver is the primary organ in the body that metabolizes foreign compounds such as drugs, alcohol, cigarette smoke, and environmental chemicals. The newly funded work will take advantage of Rajagopalan's in vitro three-dimensional liver mimic, an engineered functional tissue that contains two different hepatic cell types in a layered configuration.

Preliminary results from this work have shown that the 3D liver mimics have the ability to simultaneously maintain the observable traits of both hepatocytes, the main cell type in the liver, and liver sinusoidal endothelial cells. The investigators will use the new National Science Foundation award to discover the pathways by which these two cell types may communicate with each other.

Murali explained, "Each tissue or organ is comprised of different cell types, with each cell type responsible for specific functions. Cells exchange signals to maintain their phenotypes and to optimize their functions. When a cell receives a signal, it sets off complex cascades that trigger and modulate the activities of numerous genes and proteins. However, scientists have only partially mapped out these events. The challenge is to identify these pathways without conducting numerous expensive experiments. Through a combination of experimental and computational approaches, the team hopes to provide a more comprehensive picture of inter-cellular signaling.

Rajagopalan compared the research to the following analogy: consider a large city that has several points of entry and a complex network of roads. A number of paths may exist to enter the city and reach downtown. Only limited knowledge exists on how a person reached downtown. For instance, only the last few roads the person traveled on before reaching downtown are known. The question would remain as to how to trace the entire path taken by the traveler.

Murali specializes in so
'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
2. New malaria protein structure upends theory of how cells grow and move
3. NYSCF-Robertson investigator at Stanford creates neurons directly from skin cells of humans
4. Vitamin D increases speed of sperm cells
5. Quantum sensor tracked in human cells could aid drug discovery
6. UBC-led team develops platform to monitor hematopoietic stem cells
7. The dance of the cells: A minuet or a mosh?
8. Zebrafish regrow fins using multiple cell types, not identical stem cells
9. AgriLife Research scientists work with RNA silencing and plant stem cells
10. Species are to ecosystems as cells are to the human body, according to a mathematical model
11. Cancer scientists discover new way breast cancer cells adapt to environmental stress
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cells do talk to one another, but the question remains how
(Date:5/24/2013)... Studying complex systems like ecosystems can get messy, especially ... big unknowns like climate change. , In a ... Proceedings of the National Academy of Sciences , ... a fundamental assumption at the very heart of a ... To model how climate changes may impact biodiversity, researchers ...
(Date:5/24/2013)... frequently expressed concern in the ongoing public health debate ... those that are nutrient dense. A new study, ... Most Nutrients Per Penny," published in the journal ... the best nutritional values in the produce aisle, providing ... most other raw vegetables and delivering one of the ...
(Date:5/24/2013)... of the world,s largest and fastest growing open-access publishers, ... Frontiers in Physics . , A broad scope journal ... provide an open-science and interactive web platform for the ... articles. , Frontiers, real-time and interactive peer-review enables ... article types. With an average of three months from ...
Breaking Biology News(10 mins):Understanding the past and predicting the future by looking across space and time 2New research shows that potatoes provide one of the best nutritional values per penny 2Frontiers launches new open-access journal in physics 2Frontiers launches new open-access journal in physics 3
... Salts Emerging as New Recreational Drugs, (#1120069, Wednesday, ... bath salts as recreational drugs has greatly escalated in ... Sciences Center in Oklahoma City, Oklahoma describe an incident ... who also exhibited violent behavior upon his emergency department ...
... Exposure in the womb to bisphenol A (BPA) ... other consumer goods is associated with behavior and ... led by researchers at Harvard School of Public Health ... Fraser University in Vancouver, British Columbia. BPA ...
... identifying ideal drug combinations from billions of others which ... in Nature Chemical Biology , could be the ... to combat severe diseases and conditions. Most non-infectious ... by inflammation, which is the body,s natural defence mechanism. ...
Cached Biology News:CHEST 2011: Embargoed studies highlight new lung health research 2CHEST 2011: Embargoed studies highlight new lung health research 3CHEST 2011: Embargoed studies highlight new lung health research 4CHEST 2011: Embargoed studies highlight new lung health research 5CHEST 2011: Embargoed studies highlight new lung health research 6Exposure to chemical BPA before birth linked to behavioral, emotional difficulties in girls 2Manchester's 'first step' to perfect drug combinations 2
(Date:5/25/2013)... 25, 2013 Significant research in quantum ... been recognized with presentation of awards by the ... made 16 April during the SPIE Optics and Optoelectronics ... for optics and photonics , is an International Society ... University was presented with the 2011 ICO Galileo Galilei ...
(Date:5/25/2013)... Dennis R. HIll M.D. Radiation Oncologist at ... that recently there has been a promotion of the idea ... permanent seed, or low dose rate, brachytherapy for prostate cancer. ... energy, a shorter half life, and gives a higher biologically ... 131 has a higher average energy than the other commonly ...
(Date:5/24/2013)... Dr. Ingrid Warmuth and Anamaria Newport, MHS, PA-C, with ... announce an Open House at their Swedesboro location, 95 Woodstown ... from 10 AM to 2 PM. , During the ... will be on hand to talk to people about the ... complimentary cosmetic consultations. There will also be specials offered, such ...
(Date:5/24/2013)... WA (PRWEB) May 24, 2013 ... engineers, and industry suppliers will present technologies with ... at the annual SPIE Optics and Photonics ... Organized by SPIE, the international society for ... largest international, multidisciplinary optical sciences and technology meeting ...
Breaking Biology Technology:ICO Honors Three with Awards during SPIE Optics and Optoelectronics 2ICO Honors Three with Awards during SPIE Optics and Optoelectronics 3Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 2Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 2See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 4
... Mass. and CLEARWATER, Fla., Sept. 10 ... whole blood analyzers, and CCS Medical, Inc. a leading ... have reached a definitive agreement under which Nova Biomedical,s ... certain assets of Sanvita, Inc., a wholly-owned subsidiary of ...
... , , HOUSTON, ... a provider agreement with Beech Street Corporation, one of the ... Beech Street will assist SpectraCell with the ever-increasing administrative needs ... , , Beech Street addresses the ...
... , , HORSHAM, Pa., ... today announced that it received a Complete Response letter from ... Drug Application (NDA) for trabectedin when administered in combination with ... the treatment of women with relapsed ovarian cancer. The ...
Cached Biology Technology:Nova Biomedical and CCS Medical Reach Definitive Agreement for a Subsidiary of Nova Biomedical to Acquire Assets of CCS Medical's Subsidiary, Sanvita Inc. 2Nova Biomedical and CCS Medical Reach Definitive Agreement for a Subsidiary of Nova Biomedical to Acquire Assets of CCS Medical's Subsidiary, Sanvita Inc. 3SpectraCell Contracts With Beech Street Corporation 2FDA Issues Complete Response Letter For Trabectedin Combined With DOXIL 2
... NOS assay kit measures NOS activity by ... citrulline. This assay is simple, sensitive, and ... used with both crude and purified enzyme ... reagents for 50 total reactions. Radiolabeled arginine ...
Human Complement Component C5a MAb (Clone 295003)...
Human OSCAR MAb (Clone 259501)...
Homo sapiens retinoid X receptor, alpha...
Biology Products: