Navigation Links
Cells derived from pluripotent stem cells are developmentally immature
Date:8/17/2011

ogenitor cells, which create neurons and glia, hepatocytes, the main tissue found in the liver, and fibroblasts, common to the skin. They selected those cell types because they are easy to identify and are among the most commonly differentiated cells made from pluripotent stem cells. They also represent cell types found in the three germ layers, the endoderm, mesoderm and ectoderm, where the first cell fate decisions are made, Lowry said.

The progeny of the human pluripotent stem cells were compared to each other using their gene expression patterns, functionality and appearance. There was essentially little or no difference between them, Lowry said. Then the work began to compare them to equivalent cell types found in humans.

"One important reason to do this is to ensure that the cells we are creating in the Petri dish and potentially using for transplantation are truly analogous to the cells originally found in humans," said Michaela Patterson, first author of the study and a graduate student researcher. "Ideally, they should be a similar as possible."

What the team found was that while the progeny were alike, they bore striking differences from the same cells found in humans when analyzing their gene expression. A significant number of genes, about 100, were differentially expressed in the cell types made from pluripotent stem cells, Lowry said.

About half of those differentially expressed genes are normally thought to be strictly expressed in pluripotent stem cells, which have the potential to differentiate into any cell of the three germ layers. Those genes had not been turned off even after the cell had differentiated into either a neural progenitor cell, hepatocyte or a fibroblast, Patterson said.

"Previously, we assumed that all pluripotency genes get shut off right away, after the fetus begins developing," Patterson said. "We found that this is not the case, and in fact some of these genes remain expressed.
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Malignant stem cells may explain why some breast cancers develop and recur
2. Childhood eye tumor made up of hybrid cells with jumbled development
3. Stem cells central to pathogenesis of mature lymphoid tumors
4. Gladstone scientists offer new insight into the regulation of stem cells and cancer cells
5. A novel mechanism that regulates pro-inflammatory cells is identified
6. Researchers use human cells to engineer functional anal sphincters in lab
7. Researchers gain new insights into how tumor cells are fed
8. Cells die so defensive organs can live
9. Disappearance of genetic material allows tumor cells to grow
10. Solar cells get a boost from bouncing light
11. NTU unveils new center to develop solar cells and clean energy systems of tomorrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... RICHLAND, Wash. Think of the pressure change you feel ... tall building. Imagine how you,d feel if that elevator carried ... Everest in the blink of an eye. , That,s ... the turbulent waters near a dam. For some, the change ... die or are seriously injured. , In an article in ...
(Date:4/14/2014)... collaborators have reconstructed the phylogeny and biological history for ... region of the Earth surrounding the equator. In-depth ... species new to science, each having previously been confused ... on this group began, Sturnira has grown ... were described in a new study, published online in ...
(Date:4/14/2014)... an animal stops to look around its environment, neuroscientists ... the birth of a memory. , Using lab ... neuroscience in the Zanvyl Krieger Mind/Brain Institute at Johns ... the rats frequently paused to inspect their environment with ... this behavior activated a place cell in their brain, ...
Breaking Biology News(10 mins):Making dams safer for fish around the world 2Making dams safer for fish around the world 3Making dams safer for fish around the world 4Making dams safer for fish around the world 5Three new species of yellow-shouldered bats discovered in museum collections 2Three new species of yellow-shouldered bats discovered in museum collections 3Neuroscientists: Brain activity may mark the beginning of memories 2Neuroscientists: Brain activity may mark the beginning of memories 3
... years of exhaustive analysis led by a University of Alberta ... exploded from just a handful to more than 4,000. ... ailing patient looks at something like 10 to 20 chemicals," ... blood chemicals that doctors can potentially look at to diagnose ...
... 24, 2011 For a week in March, the permanent ... and other attractions becomes the world capital of science as ... 241st National Meeting & Exposition of the American Chemical Society ... world,s largest scientific society, and the sessions in balmy Anaheim ...
... identified a strain of probiotic bacteria that may be useful ... They report their findings in the February 2011 issue of ... H. pylori is considered one of the major risk ... ulcers," write the researchers. "Currently, antibiotic-based treatment for ...
Cached Biology News:Researcher lists more than 4,000 components of blood chemistry 2American Chemical Society National Meeting & Exposition, March 27-31, Anaheim, Calif. 2Probiotic identified to treat ulcers 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... trademark owners have been battling search engines and online ... that trigger online advertising. Two recent and conflicting rulings ... law to the new keyword technology can be a ... a recent court ruling on advertising triggered by the ...
... high gas costs and poor sport utility vehicle (SUV) ... at the University of Wisconsin-Madison has spent the last ... fuel-efficient SUVs in North America. The principles behind the ... incorporated into mass-production hybrid SUVs. , ,The effort is ...
... Wis. - Before Gov. Jim Doyle ... of stem cell research, a key Republican legislator had already ... projects. , ,The projects, which now are the subject of ... the Doyle Administration by State Sen. Ted Kanavas , ...
Cached Biology Technology:Keyword advertisers win some, lose some 2Keyword advertisers win some, lose some 3Keyword advertisers win some, lose some 4Keyword advertisers win some, lose some 5UW-Madison hybrid-vehicle team places second nationally 2GOP lawmaker faults Doyle for IT problems 2GOP lawmaker faults Doyle for IT problems 3
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
...
Biology Products: