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'Celldance 2011' reveals beauty and danger in microscopic world of cells
Date:12/2/2011

daughter" cells has a chromosome from each pair. Cell biologists refer to this cellular process as spindle assembly during mitosis.

The second place "Celldance" award singles out "Mechanosensing," by Justin Mih, Sc.D., of Matrigen, LLC, in Worcester, MA. The video of time-lapse images illustrates that cell morphology and perhaps other aspects of cell function can be controlled by the stiffness of the extracellular matrix the tissue that provides structural support to cells. The video shows lab cultures of human fibroblasts, the most common cells in connective tissues in the body.

The video, "Live Imaging of Cycling and Arrested Tumor Cells," will be recognized with the third-place award. Created by Neil Ganem, Ph.D., of the Dana-Farber Cancer Institute in Boston, the video shows tetraloid cells during the process known as cell cycle arrest, which prevents these abnormal cells from completing cell division, and thereby replication. Tetraloid cells, which have an excess of chromosomes, are defective byproducts of cell division and long recognized as tumor promoters. However, these cells are normally prevented from dividing by the activation of the p53 apoptosis gene.

"Celldance 2011" judges, who are ASCB members, recognized the following videos with "Honorable Mentions."

  • "Drosophila Embryo Development," by U. Serdar Tulu, Duke University.

  • "Hurricane: Cell Cytoplasm Movements," by Dong-Hwee Kim, Johns Hopkins University.

  • "Live Fluorescence Imaging of Fibroblasts" by Luo Weiwei, Mechanobiology Institute, University of Singapore.


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Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
American Society for Cell Biology
Source:Eurekalert

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