The second place "Celldance" award singles out "Mechanosensing," by Justin Mih, Sc.D., of Matrigen, LLC, in Worcester, MA. The video of time-lapse images illustrates that cell morphology and perhaps other aspects of cell function can be controlled by the stiffness of the extracellular matrix the tissue that provides structural support to cells. The video shows lab cultures of human fibroblasts, the most common cells in connective tissues in the body.
The video, "Live Imaging of Cycling and Arrested Tumor Cells," will be recognized with the third-place award. Created by Neil Ganem, Ph.D., of the Dana-Farber Cancer Institute in Boston, the video shows tetraloid cells during the process known as cell cycle arrest, which prevents these abnormal cells from completing cell division, and thereby replication. Tetraloid cells, which have an excess of chromosomes, are defective byproducts of cell division and long recognized as tumor promoters. However, these cells are normally prevented from dividing by the activation of the p53 apoptosis gene.
"Celldance 2011" judges, who are ASCB members, recognized the following videos with "Honorable Mentions."
|Contact: Cathy Yarbrough|
American Society for Cell Biology